Article
Environmental Sciences
Ke Jing, Ying Li, Chi Yao, Chenxue Jiang, Jing Li
Summary: Antibiotics in natural surface waters have harmful effects on aquatic organisms. Stream biofilms, consisting of algae, bacteria, fungi, and other microorganisms, can serve as biological indicators for detecting antibiotics in polluted aquatic environments. However, the potential of stream biofilms for antibiotic biotransformation has not been fully explored. Recent studies have shown that exposure to both high and sub-minimum inhibitory concentrations of antibiotics can promote the development of antibiotic resistance genes in stream biofilms. This review explores the distribution behavior of antibiotics in stream biofilms and their contribution to antibiotic resistance acquisition and spread.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Immunology
Ailing Zhao, Jiazheng Sun, Yipin Liu
Summary: Bacterial biofilms are complex microbial communities surrounded by extracellular polymeric substances. They are a significant problem in treating bacterial infections and can exhibit increased resistance to antibiotics, causing device-related and non-device infections and posing a serious threat to global health. Therefore, early detection and search for new treatments are essential. This paper systematically reviews the formation, infections, detection methods, and potential treatment strategies of bacterial biofilms, aiming to provide researchers with the latest progress in their detection and treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Medicine, Research & Experimental
Celia Sahli, Sergio E. Moya, John S. Lomas, Christine Gravier-Pelletier, Romain Briandet, Miryana Hemadi
Summary: This article introduces the spatially-organized communities of microorganisms called biofilms and their interactions with antimicrobials. The limitations of antibiotic treatments are discussed, and alternative approaches using nanoparticles are presented. The aim of this article is to eradicate bacterial biofilms and fight antimicrobial tolerance using nanobiotechnology-based approaches.
Review
Microbiology
Jackson Luu, Valerie J. Carabetta
Summary: Protein acetylation is a crucial posttranslational modification in bacteria, regulated by enzymatic and nonenzymatic mechanisms. Research on acetylation in bacterial virulence and biofilm formation is ongoing, shedding light on its impact on host-pathogen interactions and antimicrobial resistance.
Article
Chemistry, Multidisciplinary
Xufeng Zhu, Jiaqi Guo, Yonglan Yang, Jie Liu
Summary: In this study, antibiotic-loaded mesoporous nanozymes (HA@MRuO2-Cip/GOx) were developed to overcome bacterial resistance and activate local immunosuppression in the biofilm microenvironment (BME). The nanocatalyst effectively disrupted the biofilm and enhanced the killing of planktonic bacteria by cleaving extracellular DNA (eDNA). It also induced macrophage polarization and enhanced phagocytosis, ultimately leading to an efficient treatment of MRSA bacterial lung infections.
Article
Multidisciplinary Sciences
Charlotte E. Melia, Jani R. Bolla, Stefan Katharios-Lanwermeyer, Daniel B. Mihaylov, Patrick C. Hoffmann, Jiandong Huo, Michael R. Wozny, Louis M. Elfari, Jan Bohning, Ashleigh N. Morgan, Charlie J. Hitchman, Raymond J. Owens, Carol Robinson, George A. O'Toole, Tanmay A. M. Bharat
Summary: Bacteria, such as Pseudomonas aeruginosa, form multicellular biofilm communities where cell-cell interactions are mediated by CdrA molecules tethering cells together through polysaccharide binding partners. Targeting functional CdrA molecules with nanobodies could inhibit bacterial biofilm formation or disrupt preexisting biofilms, showing promise in preventing or treating chronic bacterial infections.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Adriely Goes, Lucia Vidakovic, Knut Drescher, Gregor Fuhrmann
Summary: The study demonstrates that vesicles derived from myxobacteria Cystobacter velatus Cbv34 and Cystobacter ferrugineus Cbfe23 are highly effective at inhibiting the formation and disrupting biofilms by different bacterial species.
Review
Immunology
Amanda N. N. Samuels, Erin R. R. Wang, Gregory A. A. Harrison, Joy C. C. Valenta, Christina L. L. Stallings
Summary: This article discusses the impact of bacterial central carbon metabolism on Mtb drug tolerance and proposes that these metabolic pathways could be potential drug targets. By better understanding the physiological state of Mtb in the host, we can hope to treat tuberculosis more effectively.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Rajib Dey, Sudip Mukherjee, Riya Mukherjee, Jayanta Haldar
Summary: Gram-negative bacterial infections with significant antibiotic resistance can be effectively treated by combining obsolete antibiotics with non-antibiotic adjuvants that target bacterial membranes. The development of a small molecular adjuvant with moderate membrane perturbation in bacterial cells and no toxicity to mammalian cells enhances the internalization of antibiotics and inhibits the efflux machinery, revitalizing the efficacy of various classes of antibiotics. This combination therapy demonstrates potent bactericidal activity against biofilms and multi-drug resistant infections, with good biocompatibility and antibacterial efficacy. The study highlights the potential of this approach for treating multi-drug resistant infections.
Article
Microbiology
Jordy Evan Sulaiman, Lexin Long, Pei-Yuan Qian, Henry Lam
Summary: Elasnin, a newly reported antibiofilm agent, has been found to have superior activity in eradicating daptomycin-resistant MRSA strain biofilms compared to the wild type. This study highlights the lower expression of key proteins involved in pathogenesis and cell adhesion in the daptomycin-resistant strain, leading to weaker biofilm development. Elasnin shows great potential for clinical use in settings with daptomycin-resistant strains and biofilm formation.
MICROBIOLOGY SPECTRUM
(2022)
Review
Biochemistry & Molecular Biology
J. Jenkins, L. J. Worrall, N. C. J. Strynadka
Summary: The bacterial injectisome is a crucial nanomachine that plays a key role in the pathogenesis of Gram-negative bacteria by injecting protein effectors into host cells. Cryoelectron microscopy has greatly contributed to our understanding of the molecular structure and mechanism of the injectisome over the past 30 years.
TRENDS IN BIOCHEMICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Khezar Hayat, Noor Fatima, Muhammad Farooq Umer, Farman Ullah Khan, Faiz Ullah Khan, Zia ul Rehman Najeeb, Muhammad Abuzar Ghaffari, Syed Qasim Raza, Wenchen Liu, Chen Chen, Yu Fang
Summary: This study examined the understanding and perception of Pakistani medical students about antibiotics and resistance, as well as their preparedness for antimicrobial stewardship programs. The results showed that while the students had a decent understanding of antibiotics, they lacked preparation in areas such as interpreting microbiological results and antibiotic spectrum.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Dana F. Stamo, Prashant Nagpal, Anushree Chatterjee
Summary: CdTe-2.4 eV quantum dots in combination with antibiotics have the potential to nearly eradicate biofilms formed by various drug-resistant bacteria.
NANOSCALE ADVANCES
(2021)
Article
Infectious Diseases
Thomas Bjarnsholt, Marvin Whiteley, Kendra P. Rumbaugh, Philip S. Stewart, Peter O. Jensen, Niels Frimodt-Moller
Summary: Standard doses of antibiotics are not effective in treating chronic soft tissue and bone infections. Taking the infectious microenvironment into account could improve the treatment as the microenvironment can cause bacteria to become resistant to antibiotics. Susceptibility testing should be conducted in conditions that resemble the actual infectious microenvironments to guide antibiotic recommendations.
LANCET INFECTIOUS DISEASES
(2022)
Article
Critical Care Medicine
Michiel Schinkel, Ketan Paranjape, Justin Kundert, Rishi S. Nannan Panday, Nadia Alam, Prabath W. B. Nanayakkara
Summary: The study investigated whether subgroups of sepsis patients benefit from early administration of antibiotics in a prehospital setting and which key traits drive these benefits. An interaction between age and benefits of early antibiotics for sepsis was found, which has not been reported before. This new insight may have major implications for clinical practice in providing more effective care for younger sepsis patients.
