4.7 Article

Disclosing the nature of thermo-responsiveness of poly(N-isopropyl acrylamide)-based polymeric micelles: aggregation or fusion?

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 56, Pages 11198-11201

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc02641e

Keywords

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Funding

  1. National Natural Science Foundation of China [21174107, 21374080]
  2. Shanghai 1000 Plan
  3. Eastern Scholar program
  4. open fund for characterization at Tongji University [0002014118]

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The apparent size increase of poly(N-isopropyl acrylamide) ( PNIPAM)-based polymericmicelles upon heating was usually ascribed to their volume growth or aggregation in aqueous solution. Herein we designed a photo-cross-linkable PNIPAM-based copolymer and proposed another thermo-responsive behaviour - fusion, which is disclosed by transmission electron microscopy (TEM) after in situ fixing morphologies at desired temperatures.

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