Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 69, Issue -, Pages 967-976Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2016.08.011
Keywords
Sericin; Genipin; Nanoparticles; Desolvation; Crosslinking; Antihyperlipidemic activity
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The objective of this study was to demonstrate the therapeutic as well as biopolymer like characteristics of naturally occurring sericin protein for development of nanoparticulate system of atorvastatin (Atr) to improve therapeutic effect and to reduce toxicity. The sericin encapsulated atorvastatin nanoparticles (Seri-Atr NPs) were prepared by desolvation method utilizing genipin (Gn) as a natural and nontoxic crosslinker. The optimized NPs exhibited small particle size (166 +/- 0.30 nm), high entrapment efficiency (91 +/- 0.69%) and uniform spherical shape with sustained release profile. Moreover, the results of pharmacolcinetic studies indicated an increase in AUC(0-infinity) of NPs (1189.74 +/- 52.3 h ng/ml) compared with Atr (501.84 +/- 66 h ng/ml). The cellular uptake of NPs suggested an interaction of negatively charged particles with the cell surface and considerable reduction in systemic toxicity. Histopathology studies also demonstrated the therapeutic potential of sericin and cytocompatibility. Hence, genipin crosslinked sericin based nanoparticles represents a promising nanoplatform for improved therapeutic efficiency of Atr. (C) 2016 Elsevier B.V. All rights reserved.
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