Article
Chemistry, Physical
Pedro Akira Bazaglia Kuroda, Carlos Roberto Grandini, Conrado Ramos Moreira Afonso
Summary: The technique of micro-arc oxidation (MAO) has been used to alter the surface properties of titanium alloys for biomedical purposes, enhancing their characteristics as an implant. The MAO process allows the incorporation of bioactive components like calcium, phosphorus, and magnesium, improving the corrosion resistance of the alloys. This study successfully modified the surfaces of two titanium alloys, TTZN1 and TTZN2, through MAO treatment, incorporating Ca, P, and Mg elements.
Article
Materials Science, Multidisciplinary
L. Maj, D. Wojtas, A. Jarzebska, M. Bieda, K. Trembecka-Wojciga, R. Chulist, W. Koziol, A. Goral, A. Trelka, K. Janus, J. Kawalko, M. Kulczyk, F. Muhaffel, H. Cimenoglu, K. Sztwiertnia
Summary: This work studied the microstructure of titania coating fabricated on the surface of hydrostatically extruded titanium grade 4 using the micro-arc oxidation method. The investigation revealed that a well-adherent porous coating is produced on the top surface and side walls of the extruded rod. The presence of a continuous amorphous layer compensates for the effect of anisotropic substrate, resulting in a comparable and homogenous microstructure with a large number of micropores.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Giovana Collombaro Cardoso, Katia Barbaro, Pedro Akira Bazaglia Kuroda, Luca Imperatori, Angela De Bonis, Roberto Teghil, Mariangela Curcio, Elisa Innocenzi, Victoria Yu. Grigorieva, Gianluca Vadala, Carlos Roberto Grandini, Julietta V. Rau
Summary: Micro-arc oxidation (MAO) is a surface modification technique used to improve the surface properties of titanium alloys. This study focused on the surface modification of the β Ti-30Nb-5Mo alloy using MAO method and incorporating calcium, phosphorus, magnesium, and zinc. The results showed that the coating's porosity, roughness, and crystallinity increased with increasing zinc concentration, and the antimicrobial activity was promoted. Incorporating zinc on the surface did not negatively affect cell growth.
Article
Engineering, Multidisciplinary
Eren Yilmaz
Summary: Surface treatments on titanium and its alloys are crucial for improving bio properties, particularly for implant applications. The calcium phosphate/chitosan coating showed antibacterial properties and suitable surface roughness for bone development, making it a potential choice for dental and orthopedic implants.
JOURNAL OF BIONIC ENGINEERING
(2021)
Article
Materials Science, Coatings & Films
Zi-Yi Zhang, Tian-Yu Huang, Da-Jun Zhai, Hai-Bo Wang, Ke-Qin Feng, Lin Xiang
Summary: In this study, hydroxyapatite coatings with different amounts of Sr doping were prepared on the surface of titanium alloy using micro-arc oxidation. The coatings' characteristics and bioactivity were evaluated, and it was found that the Sr-doped MAO coatings promote the proliferation of preosteoblasts, with higher Sr content leading to higher cell proliferation.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Karina M. Zaniolo, Sonia R. Biaggio, Joni A. Cirelli, Mariana A. Cominotte, Nerilso Bocchi, Romeu C. Rocha-Filho
Summary: Titanium and its alloys are widely used biomaterials in dental and orthopedic implant applications. Researchers have proposed a method to produce a TiO2 coating on titanium through micro-arc oxidation in a green electrolyte. The modified Ti surface exhibited enhanced bioactivity and improved performance in biological tests.
MATERIALS RESEARCH EXPRESS
(2022)
Article
Materials Science, Coatings & Films
Kunyu Ju, Zhongwei Zhao
Summary: In this study, the failure of MAO coatings on titanium was observed for the first time under cathodic conditions in a 6% H2O2 solution. The necessary conditions for failure were determined and the mechanism was summarized based on titanium corrosion. This treatment method is effective for MAO coatings containing Ca, Si, P, or Al and provides an alternative for non-conforming coatings and retired workpieces treatment.
SURFACE & COATINGS TECHNOLOGY
(2023)
Article
Materials Science, Coatings & Films
Shengjie Wang, Lu Deng, You Lv, Tong Zhang, Xinxin Zhang, Zehua Dong, Guangyi Cai
Summary: Incorporating copper into the surface layer of metallic titanium substrate is an effective method to enhance its antifouling ability. In this study, a Cu-modified TiO2 coating was produced on metallic Ti through micro-arc oxidation (MAO) process using an aqueous electrolyte containing Na2Cu-EDTA. The concentration of Na2Cu-EDTA affects the microstructure, corrosion resistance, and antifouling capability of the Cu-modified TiO2 coatings.
SURFACE & COATINGS TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Morena Petrini, Tania Vanessa Pierfelice, Emira D'Amico, Natalia Di Pietro, Assunta Pandolfi, Camillo D'Arcangelo, Francesco De Angelis, Domitilla Mandatori, Valeria Schiavone, Adriano Piattelli, Giovanna Iezzi
Summary: Current research on dental implants has focused on the influence of surface roughness on osseointegration rate, while studies on developing surfaces to improve interaction with peri-implant soft tissues are lacking. This study showed that implant discs with Ti-S surfaces promoted adhesion and proliferation of gingival fibroblasts in vitro, suggesting their potential for in vivo applications. Further research is needed to confirm these findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Binbin Kang, Dongmei Lan, Chao Yao, Ping Liu, Xiaohong Chen, Shengcai Qi
Summary: This study fabricated volcano-shaped microporous TiO2 coatings doped with Cu via micro-arc oxidation on Ti, with Cu uniformly distributed throughout the coating. The Cu-doped coating improved bone mesenchymal stem cell proliferation and osteogenic differentiation, and exhibited excellent antibacterial properties against S. aureus and P. gingivalis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Yong Zhang, Wei Yang, Sen Yu, Liqun Wang, Xiqun Ma, Wei Gao, Nan Lan, Wenting Shao, Jian Chen
Summary: The addition of CuSO4 to (NaPO3)(6) base solution successfully prepared copper-containing micro-arc oxidation coatings on TC4 titanium alloys. The results showed that the addition of copper resulted in an increase in coating thickness and roughness, as well as a decrease in the coefficient of friction. The antibacterial properties of the coatings were improved with the addition of CuSO4 at certain concentrations. However, the corrosion resistance of the copper-doped coatings did not exceed that of the undoped coatings.
Review
Materials Science, Ceramics
Huixia Guo, Ziye Liu, Yongxin Wang, Jinlong Li
Summary: Adding silicate can increase the density of the coating, and phosphate-aluminate ceramic layer exhibits the lowest wear rate in various environments. The friction coefficient and wear rate of MAO coating in seawater are lower than those in ambient air due to the boundary lubrication effect of seawater, with the presence of divalent metal salts making seawater more lubricous than other salt solutions.
CERAMICS INTERNATIONAL
(2021)
Article
Materials Science, Coatings & Films
Zi-Yi Zhang, Tian-Yu Huang, Da-Jun Zhai, Hai-Bo Wang, Ke-Qin Feng, Lin Xiang
Summary: Coatings with different content of Zn element were successfully formed on Ti6Al4V substrates by micro-arc oxidation (MAO) to enhance the bioactivity and antibacterial activity of titanium alloys. The microstructure and composition of the coatings were characterized, and their bioactive and antibacterial activities were evaluated. The results showed that increasing Zn2+ concentration in the electrolyte resulted in changes in the properties and composition of the coatings, including thickness, surface roughness, porosity, and crystalline phases. The Zn-doped coatings improved cell viability and exhibited antibacterial activity.
SURFACE & COATINGS TECHNOLOGY
(2023)
Article
Materials Science, Ceramics
Yixiong Gao, Shu Xiao, Hao Wu, Chunming Wu, Guohua Chen, Yansheng Yin, Paul K. Chu
Summary: This study aims to enhance the performance of micro-arc oxidation (MAO) coatings by integrating hexagonal boron nitride (h-BN) nanoparticles. The results show that h-BN integration reduces porosity and roughness, while improving hardness, adhesion, corrosion resistance, and wear resistance.
CERAMICS INTERNATIONAL
(2023)
Article
Materials Science, Coatings & Films
Yakup Yurekturk
Summary: In this study, an Al2O3 ceramic coating was formed on a pure titanium surface using duplex coating technology. Diffusion annealing treatment resulted in a denser structure, higher hardness and elastic modulus, and improved friction and wear resistance for the modified MAO coating.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Julia S. Markl, Werner E. G. Mueller, Dayane Sereno, Tarek A. Elkhooly, Maria Kokkinopoulou, Johan Garderes, Frank Depoix, Matthias Wiens
BIOTECHNOLOGY AND BIOENGINEERING
(2020)
Article
Chemistry, Applied
A. M. Hezma, Tarek A. Elkhooly, Gamal S. El-Bahy
JOURNAL OF POROUS MATERIALS
(2020)
Article
Biotechnology & Applied Microbiology
Wei He, Yudong Zheng, Qingling Feng, Tarek A. Elkhooly, Xujie Liu, Xing Yang, Yansen Wang, Yajie Xie
Letter
Oncology
Xujie Liu, Amita M. Vaidya, Da Sun, Yan Zhang, Nadia Ayat, Andrew Schilb, Zheng-Rong Lu
CANCER COMMUNICATIONS
(2020)
Article
Materials Science, Multidisciplinary
Xujie Liu, Xiaoning Li, Ranran Zhang, Liping Wang, Qingling Feng
Summary: Dual microspheres based on thiolated chitosan (CS-TBA)/CaCO3 were fabricated by ionic gelation method, combining the benefits of CS-TBA for improved water solubility and CaCO3 for mesoporous structure, showing controlled drug release in vitro and having potential applications in tissue engineering and regenerative medicine.
Article
Biochemistry & Molecular Biology
Wangqing Bian, Zhenxing Pan, Yakun Wang, Wei Long, Zefeng Chen, Niping Chen, Yaoxun Zeng, Jiongpeng Yuan, Xujie Liu, Yu-Jing Lu, Yan He, Kun Zhang
Summary: The study demonstrated the significant effectiveness of thiazole orange-based Mito-BWQ in tumor treatment by generating high heat to kill cancer cells through exogenous laser irradiation.
BIOORGANIC CHEMISTRY
(2021)
Article
Engineering, Biomedical
Mostafa A. Abdelshafi, Salma M. Fathy, Tarek A. Elkhooly, Fikry M. Reicha, Manal F. Osman
Summary: By self-assembling hydroxyapatite on collagen fibers in different ratios, we can improve the micro-tensile bond strength and potentially enhance adhesion to the carious zone and its durability.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Xujie Liu, Yakun Wang, Yan He, Xiaofeng Wang, Ranran Zhang, Akash Bachhuka, Rahul Madathiparambil Visalakshan, Qingling Feng, Krasimir Vasilev
Summary: The study reveals that surface chemistry and topography can synergistically influence the morphology, focal adhesion formation, and osteogenic/adipogenic differentiation of human mesenchymal stem cells. This suggests that different material properties can have a significant impact on cell response and highlights the importance of designing functional biomaterials.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Biomaterials
Zixu Wang, Han Wang, Junjie Xiong, Jiahao Li, Xiaomin Miao, Xingzi Lan, Xujie Liu, Wenlong Wang, Nian Cai, Yadong Tang
Summary: In this study, a micro/nano hierarchical scaffold for bone tissue engineering was fabricated by combining MEW and SE techniques. The addition of gelatin nanofibers improved the hydrophilicity and slightly enhanced the mechanical strength of the scaffolds. MEW/SE composite scaffolds showed higher cell adhesion efficiency, improved cell proliferation, and higher osteoinductive ability compared to PCL MEW scaffolds.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Public, Environmental & Occupational Health
Wenxia Wang, Tingting Chen, Zhen Li, Qiting Tan, Zhenbang Meng, Hailun Qiu, Xujie Liu, Junxia Zheng
Summary: Different types of face masks were evaluated based on multiple international standards, with folding masks showing the highest particulate filtration efficiency and cup masks having the highest respiratory resistance. Generally, masks are more likely to meet the criteria of the EN149-2001+A1:2009 standard in terms of PFE, while meeting the requirements of the GB2626-2019 and NIOSH 42 CFR Part84-2019 standards for respiratory resistance is easier.
AMERICAN JOURNAL OF INFECTION CONTROL
(2022)
Article
Materials Science, Multidisciplinary
Xujie Liu, Jiongpeng Yuan, Jian Zhang, Rahul Madathiparambil Visalakshan, Wenxia Wang, Yongxiao Xiang, Yan He, Qingling Feng, Krasimir Vasilev
Summary: The plasma deposited polyoxazoline (PPOx) with surface nanotopography gradient showed suppressed adhesion of S. aureus and enhanced initial attachment and spreading of hMSCs, as well as promoted osteogenic differentiation of hMSCs. The RhoA/ROCK signaling pathway may be involved in the enhancement of osteoinductive capacity of PPOx surface by nanotopography.
Article
Engineering, Biomedical
Zefeng Chen, Yaoxun Zeng, Niping Chen, Mingxia Zhang, Yakun Wang, Zhenxing Pan, Jiongpeng Yuan, Zhaoyi Ye, Xiaojing Li, Wangqing Bian, Haihong Li, Kun Zhang, Yan He, Xujie Liu
Summary: This study proposes a novel approach for the transport of metal ions using polyethylene glycol. By a simple synthesis method, 31 different metal ion-based nanoparticles were successfully synthesized and demonstrated their potential for cancer theranostics.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Nanoscience & Nanotechnology
Wangqing Bian, Yakun Wang, Zhenxing Pan, Niping Chen, Xiaojing Li, Wing-Leung Wong, Xujie Liu, Yan He, Kun Zhang, Yu-Jing Lu
Summary: Photothermal therapy (PTT) is a promising approach for cancer treatment, with the potential to reduce the adverse effects of traditional chemotherapy. Recent research highlights the application of functionalized nanomaterials in PTT and combined therapies, offering new insights for future disease treatment.
ACS APPLIED NANO MATERIALS
(2021)
Article
Infectious Diseases
Reham M. Goda, Ahmed M. El-Baz, Eman M. Khalaf, Nada K. Alharbi, Tarek A. Elkhooly, Mohamed M. Shohayeb
Summary: This study successfully inhibited bacterial colonization on urinary tract catheters by coating them with silver nanoparticles. The silver nanoparticles significantly inhibited the colonization of antibiotic-resistant clinical bacteria and showed stronger antibacterial effects against Gram-negative bacteria.
Article
Biotechnology & Applied Microbiology
Mostafa Mabrouk, Tarek A. Elkhooly, Shaimaa K. Amer
Summary: This research investigated the influence of different Actinomycete strains on the properties of silver nanoparticles, finding that Streptomyces spiralis and Streptomyces rochei were able to produce AgNPs. The diversity and molecular weights of proteins secreted by these strains affected the polydispersity of AgNPs, highlighting the importance of biomacromolecule sizes on the physical properties of biogenic nanoparticles.
JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
