Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 69, Issue -, Pages 1222-1228Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2016.08.036
Keywords
Chitosan derivatives; Reduced graphene oxide; Alginate; Beads; Fluorescein sodium; Drug delivery
Categories
Funding
- National Natural Science Foundation of China [51403069]
- Natural Science Foundation of Guangdong Province [2014 A030313252]
- Characteristic Innovation project from Department of Education of Guangdong Province
Ask authors/readers for more resources
This work reported chitosan derivatives (CSD)/reduced graphene oxide (rGO) blending with alginate to prepare hydrogel beads for small-molecule drug delivery for the first time. At the beginning, graphene oxide (GO) was successfully reduced using diverse CSD as reducing and stabilizing agents via facile heating. Then the obtained CSD/rGO was blended with alginate and crosslinked into hydrogel beads in CaCl2 solution. Finally, the beads were systematically evaluated as novel vehicles for pH-responsive small-molecule drug delivery. The optimal CSD/rGO/alginate beads showed a high drug-loading efficiency of 82.8% on small-molecule fluorescein sodium (FL), outstanding sustainable release of 71.6% upon 150 h at a physiological pH and quick-release of 82.4% drug content at 20 h in an acidic medium. Additionally, the cytotoxicity assay result suggested that the CSD/rGO/alginate beads showed negligible cytotoxicity to hepatic stellate cell lines, opening up possibilities for safe and efficient drug delivery. (C) 2016 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available