Article
Orthopedics
Hongri Wu, Jiulin Tan, Dong Sun, Xiaohua Wang, Jie Shen, Shulin Wang, Qijie Dai, Zhiyuan Wei, Gang Li, Sien Lin, Fei Luo, Zhao Xie
Summary: This study found that the insertion of polymethyl methacrylate (PMMA) bone cement can form an induced membrane (IM) containing multipotent progenitor cells similar to periosteum, and these cells share similar characteristics with periosteum stem cells (PSCs) in bone regeneration. The study also revealed the existence of multiple subsets with differences in osteogenic differentiation.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Engineering, Biomedical
Shue Jin, Jing Gao, Renli Yang, Chen Yuan, Ruili Wang, Qin Zou, Yi Zuo, Meifang Zhu, Yubao Li, Yi Man, Jidong Li
Summary: We demonstrate a simple and feasible method to address the shrinkage of PLGA fibers through a core-shell structure strategy. The modified fibrous scaffold shows potential in promoting osteogenic differentiation and neovascularization for vascularized bone regeneration.
BIOACTIVE MATERIALS
(2022)
Article
Materials Science, Biomaterials
Yonggang Zhao, Yang Xiong, Jingchuan Zheng, Wenyao Kongling, Junlin Chen, Chengli Li, Peilun Hu, Shuhui Yang, Xiumei Wang
Summary: An artificial periosteum composed of hierarchically assembled Mg-doped mineralized collagen microfibrils has been successfully fabricated, showing excellent mechanical properties and biological activities, and holding great promise for bone tissue regeneration.
BIOMATERIALS SCIENCE
(2023)
Review
Engineering, Biomedical
Jinsong Wang, Guobao Chen, Zhong M. Chen, Fu P. Wang, Bin Xia
Summary: The role of periosteum in the treatment of bone defects has been gradually discovered, but there are still challenges due to limited transplantable periosteum. Biomimetic periosteal scaffolds that mimic the composition and structure of natural periosteum have emerged. This article reviews the current preparation methods of biomimetic periosteal scaffolds based on various biomaterials, providing a systematic perspective for future preparation.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2023)
Article
Engineering, Biomedical
Zonghan Xu, Liang Wu, Yu Tang, Kun Xi, Jincheng Tang, Yichang Xu, Jingzhi Xu, Jian Lu, Kaijin Guo, Yong Gu, Liang Chen
Summary: This study presents a hybridized biphasic bionic periosteum for regulating the bone immune microenvironment and promoting bone regeneration. The biomimetic membrane intercepts IL-4 release, maintains moderate inflammatory response, and promotes M2 macrophage polarization, which improves vascular maturation and osteogenesis. The controlled regulation of the bone immune microenvironment leads to faster and better bone defect repair.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Laijun Liu, Yuna Shang, Chaojing Li, Yongjie Jiao, Yanchen Qiu, Chengyi Wang, Yuge Wu, Qiuyun Zhang, Fujun Wang, Zhimou Yang, Lu Wang
Summary: The developed hierarchical nanostructured electrospun membrane with periosteum-mimic microenvironment, incorporating a calcium-binding peptide, showed enhanced osteogenic differentiation of rat-bone marrow-derived mesenchymal stem cells (rBMSCs) and promoted the regeneration of vascularized bone tissue.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Huifan Liu, Yihua Shi, Yufan Zhu, Ping Wu, Zhouming Deng, Qi Dong, Minhao Wu, Lin Cai
Summary: A novel biomimetic periosteum was developed using functionalized piezoelectric materials to enhance the bone regeneration effect. The periosteum was fabricated using a biocompatible and biodegradable polymer matrix, antioxidized polydopamine-modified hydroxyapatite, and barium titanate. This periosteum demonstrated favorable biocompatibility, osteogenic activity, and immunomodulatory functions, and accelerated bone regeneration through endogenous piezoelectric stimulation.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Gaojie Yang, Haoming Liu, Yi Cui, Jiaqi Li, Xuan Zhou, Nuoxin Wang, Feige Wu, Yan Li, Yu Liu, Xingyu Jiang, Shengmin Zhang
Summary: The functional biomimetic membrane with micropatterns of site-specific biomineralization mimics the role of natural periosteum in bone regeneration. It can sustainably release calcium phosphate and growth factors, enhancing cell recruitment and differentiation, leading to improved vascularized ossification and accelerated new bone formation in a rat model.
Article
Chemistry, Physical
Shu Yang, Zhijie Chen, Pengzhen Zhuang, Yunkai Tang, Zehao Chen, Fei Wang, Zhengwei Cai, Jie Wei, Wenguo Cui
Summary: In this study, seamless adhesive biomimetic periosteum patches were developed to fill microcracks in defective bone and promote bone regeneration. The patches exhibited excellent self-healing properties, enhanced osteogenesis and angiogenesis, and significantly promoted blood vessel and new bone formation in a rat cranial defect model. Therefore, the proposed biomimetic periosteum patch is a promising clinical strategy for promoting bone repair.
Review
Polymer Science
Xuan Yan, Haiyan Yao, Jun Luo, Zhihua Li, Junchao Wei
Summary: This review introduces bone-tissue engineering and the use of electrospun nanofibers as scaffolds. The unique characteristics of electrospun nanofibers, such as their similarity with the extracellular matrix, larger surface areas, porosity, and processability, make them ideal candidates for bone-tissue engineering. The review highlights the functionalization of electrospun nanofibers to enhance bone regeneration and addresses the existing deficiencies in promoting osteogenesis.
Article
Dentistry, Oral Surgery & Medicine
Lucas T. Duong, Stephane Petit, Stephane Kerner, Melodie M. Clerc, Christophe Arnoult, Nunthawan Nowwarote, Thanaphum Osathanon, Benjamin P. J. Fournier, Juliane Isaac, Francois C. Ferre
Summary: A standardized critical size defect (CSD) model was developed in the mandibular alveolar bone of minipigs to investigate the role of periosteum in bone healing process. It was found that the removal of periosteum resulted in a significant decrease in bone volume and density, indicating the important role of periosteum in bone regeneration.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Materials Science, Biomaterials
Jingjing Wu, Mengyu Yao, Yonggang Zhang, Zefeng Lin, Wenwu Zou, Jiaping Li, Pamela Habibovic, Chang Du
Summary: Distinct structural properties and osteogenic capacity are important for developing guided bone regeneration membranes. The three-layered membranes designed in this study demonstrated good integration, tensile properties similar to natural periosteum, and supported attachment, proliferation, ingrowth, and osteogenic differentiation of human bone marrow-derived stromal cells.
REGENERATIVE BIOMATERIALS
(2021)
Article
Cell Biology
Xiaoru Shao, Zhong Hu, Yuxi Zhan, Wenjuan Ma, Li Quan, Yunfeng Lin
Summary: Delivery systems with time and space control have promising applications in tissue regeneration. A novel micro-RNA delivery system was constructed to promote osteogenic differentiation of mesenchymal stem cells by activating the canonical Wnt signaling pathway. The addition of this complex significantly improved the osteogenic differentiation ability of mesenchymal stem cells, enhancing the expression of ALP on the cell membrane surface and the formation of calcium nodules.
CELL PROLIFERATION
(2022)
Article
Nanoscience & Nanotechnology
Qian-Qian Wan, Kai Jiao, Yu-Xuan Ma, Bo Gao, Zhao Mu, Yi-Rong Wang, Yan-Hao Wang, Lian Duan, Ke-Hui Xu, Jun-Ting Gu, Jian-Fei Yan, Jing Li, Min-Juan Shen, Franklin R. Tay, Li-Na Niu
Summary: This study utilizes biomimetic mineralization to create a bone-mimicking material that acts as a periosteum in bone repair. The material is biocompatible, regulates immune responses, facilitates neuro-vascularization, and accelerates early-stage bone regeneration in a mouse model.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Zhihai Fan, Hongxiang Liu, Shilei Shi, Zhaozhao Ding, Zhen Zhang, Qiang Lu, David L. Kaplan
Summary: This study investigated the use of electric field induced aligned nanofiber layers to regulate the release of deferoxamine (DFO) for dynamic control of vascularization in bone regeneration. The results showed that the changeable release of DFO influenced angiogenesis and osteogenesis. Cell studies revealed the regulation of cell responses and cytokine secretion related to vascularization in the scaffolds. In vivo experiments demonstrated that the composite scaffolds with the best osteogenic capacity achieved superior bone regeneration in a rat bone defect model. The findings highlight the importance of dynamically controlling angiogenic properties for improving bone regeneration.
MATERIALS TODAY BIO
(2022)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
