Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 40, Pages 8457-8460Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc10301g
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Funding
- MEXT Japan [3306, 23115003, 26410170]
- Asahi Group Foundation
- Grants-in-Aid for Scientific Research [26410170] Funding Source: KAKEN
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A short, monodisperse additive (octa(ethylene glycol) monophenyl ether) functions to suppress aggregation of thermally and chemically denatured lysozyme. Control studies with shorter and non-amphiphilic derivatives revealed that the amphiphilic structure is essential, and octa(ethylene glycol) is nearly the minimum chain length for amphiphilic poly(ethylene glycol)s to stabilize proteins.
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