Article
Polymer Science
Moloud A. Baghbadorani, Ashkan Bigham, Mohammad Rafienia, Hossein Salehi
Summary: In this study, a novel nanocomposite fibrous scaffold composed of PCL/GT/GLN7% was fabricated through electrospinning method, and its potential for bone tissue regeneration was evaluated through various physical and chemical properties assessments in vitro. The results indicate that the ternary scaffold shows promising performance in accelerating cell attachment, proliferation, and differentiation rate for bone tissue regeneration.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Materials Science, Paper & Wood
Melika Sharahi, Ahmad Hivechi, S. Hajir Bahrami, Nahid Hemmatinejad, Peiman B. Milan
Summary: This study produced nanoparticles from walnut shells and co-electrospun them with polycaprolactone and gelatin to create nanofibers with excellent mechanical properties. The nanofiber scaffolds showed excellent viability, growth, and proliferation of adipose-derived mesenchymal stem cells.
Article
Biochemistry & Molecular Biology
Vivekananthan Sadaiyandi, Raghavendra Ramalingam, Kantha Deivi Arunachalam, D. John Thiruvadigal
Summary: This study synthesized essential oil-loaded nanofiber mats from watermelon seed, jackfruit, and papaya using electrospinning technique. These mats exhibited mechanical competence, antibacterial activity, and biocompatibility, making them promising alternatives to conventional antibacterial wound dressings.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Textiles
Rezvan Mohamadinooripoor, Soheila Kashanian, Kobra Omidfar
Summary: Electrospun composite mats of PCL/PEE were used to fabricate PCL-PEE sutures with desirable mechanical and antibacterial properties. The sutures showed promising characteristics including sustained drug release, high tensile strength, antifungal effects, and accelerated wound healing.
FIBERS AND POLYMERS
(2023)
Article
Pharmacology & Pharmacy
Cansu Ulker Turan, Yuksel Guvenilir
Summary: In recent years, there has been increasing attention on the use of biocompatible electrospun nanofibers for drug delivery applications, as they offer advantages such as high surface area and controlled drug release, while mimicking the extracellular matrix. In this study, tetracycline hydrochloride-loaded nanofibrous membranes were fabricated using a combination of synthetic polymers and natural proteins/polysaccharides to create a novel controlled drug delivery system. Various characterization techniques were used to examine the drug incorporation and release behavior, and the system showed promising drug release and antibacterial activity, making it a potential candidate for wound dressing applications in the treatment of skin infections.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Hannah A. Lacy, Vera Jencova, David Lukas, Andrei Stanishevsky
Summary: This study investigates the production of blended nanofibrous biomaterials using high-yield alternating field electrospinning (AFES) of cold-water fish skin gelatin (FGEL) and polycaprolactone (PCL). The resulting FGEL/PCL nanofibers exhibited smooth surface morphology and average diameters ranging from 237-313 nm after thermal crosslinking. In-vitro analysis demonstrated good cellular viability and mesh stability of the FGEL/PCL nanofibrous biomaterials. AFES proves to be an efficient and scalable method for producing FGEL/PCL nanofibrous biomaterials with desired characteristics.
Article
Chemistry, Multidisciplinary
Tabinda Riaz, Nafisa Gull, Atif Islam, Muhammad Rizwan Dilshad, Leonard Ionut Atanase, Christelle Delaite
Summary: Summary: A novel bilayer structure of PCL nanofibers deposited on a hydrogel layer of GE and HA was prepared using needleless electrospinning for drug delivery. IBU was successfully loaded into the nanofibrous structure, and the GH hydrogel films showed good mechanical strength and hydrophilicity. The IBU-loaded bilayer films demonstrated controlled drug release, with 45% release of IBU in 48 hours. The antibacterial analysis showed mild inhibition against E. coli in the case of IBU-loaded nanofibers, suggesting their potential as effective wound dressings.
Article
Polymer Science
Lei Wang, Yifan Huang, Binjie Xin, Tingxiao Li
Summary: Electrospun core-shell nanofibers with PLCL/GE blends show great potential as efficient drug delivery systems, providing tailored release profiles for encapsulated drugs. The materials exhibit good hydrophilicity, mechanical properties, and drug release behavior, making them a promising option for various applications in drug delivery and tissue engineering.
POLYMER INTERNATIONAL
(2021)
Article
Nanoscience & Nanotechnology
Yo-Seung Song, Bae-Yeon Kim, Dae Hyeok Yang, Deuk Yong Lee
Summary: Porous poly(epsilon-caprolactone)/gelatin (P/g) scaffolds were fabricated via electrospinning, and the effect of different P/g weight ratios on mechanical properties, porosity, moisture vapor transmission rate (MVTR), and biocompatibility of scaffolds was investigated. The scaffolds with P/g ratios of 7/3 and 6/4 exhibited excellent properties in terms of MVTR, water uptake capacity, cell viability, proliferation, attachment, and mechanical strength.
APPLIED NANOSCIENCE
(2022)
Article
Engineering, Biomedical
Liliana Liverani, Anna Liguori, Paola Zezza, Chiara Gualandi, Maurizio Toselli, Aldo R. Boccaccini, Maria Letizia Focarete
Summary: This study presents electrospun fibers loaded with bioactive glasses (BG) as well as unloaded fibers for comparison. It is proposed that the interaction between triethoxysilane groups and silanol groups at the BG particle surface leads to additional crosslinking points, enhancing the shape memory properties of the fibers. The presence of BG particles not only confers bioactivity to the fibers but also promotes the precipitation of hydroxycarbonate apatite on the fiber surface. Preliminary cytocompatibility tests show that adding BG particles does not inhibit cell viability. This novel approach expands the versatility and suitability of PCL-based composite fibers for various biomedical applications.
BIOACTIVE MATERIALS
(2022)
Review
Polymer Science
Sibusiso Alven, Blessing Atim Aderibigbe
Summary: The management of chronic wounds is challenging due to factors such as malnutrition, diseases, and bacterial infection. Wound dressings formulated from a combination of biopolymers and synthetic polymers show promising properties, especially when prepared using electrospinning technique.
Article
Pharmacology & Pharmacy
Cansu Ulker Turan, Ayse Metin, Yuksel Guvenilir
Summary: The study fabricated poly(?-pentadecalactone-co-?-caprolactone)/gelatin nanofibrous membranes for controlled release of tetracycline hydrochloride antibiotic. Various characterizations were applied to investigate drug incorporation and release mechanism. The drug release profile showed initial burst release followed by sustained release, providing antibacterial activity against different bacteria.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Samira Beikzadeh, Seyede Marzieh Hosseini, Vahid Mofid, Soghra Ramezani, Marjan Ghorbani, Ali Ehsani, Amir Mohammad Mortazavian
Summary: The research successfully fabricated ethylcellulose/polycaprolactone/gelatin nanofibers incorporating Zataria multiflora essential oil and zinc oxide nanoparticles, demonstrating good mechanical, antioxidant, antimicrobial properties and thermal stability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Ilya Nifant'ev, Victoria Besprozvannykh, Andrey Shlyakhtin, Alexander Tavtorkin, Sergei Legkov, Maria Chinova, Irina Arutyunyan, Anna Soboleva, Timur Fatkhudinov, Pavel Ivchenko
Summary: Composite fibrous scaffolds consisting of PCL and Gt were successfully fabricated using the electrospinning method. Covalent binding between PCL and Gt was achieved by introducing weak acid, resulting in complete bonding of the composite. PCL2-based films with a Gt content of 20 wt% exhibited the best set of properties.
Article
Chemistry, Multidisciplinary
Alena Opalkova Siskova, Maria Buckova, Zuzana Kronekova, Angela Kleinova, Stefan Nagy, Joanna Rydz, Andrej Opalek, Monika Slavikova, Anita Eckstein Andicsova
Summary: Nanofiber mats loaded with Diclofenac sodium salt on the base of poly(epsilon-caprolactone) were studied for their biocompatibility and ability to inhibit bacterial infections. The mats demonstrated good viability with human cells culture and showed significant activity against cancer cells. A minimal concentration of 12.5% was found to effectively eradicate both Gram-negative and Gram-positive bacteria.
Article
Mechanics
Seza Ozge Gonen, Melek Erol Taygun, Sadriye Kucukbayrak
COMPOSITE STRUCTURES
(2016)
Article
Materials Science, Ceramics
Melek Erol Taygun, Vahide Hocaoglu
INTERNATIONAL JOURNAL OF APPLIED GLASS SCIENCE
(2018)
Article
Chemistry, Physical
Aysen Akturk, Melek Erol Taygun, Funda Karbancioglu Guler, Gultekin Goller, Sadriye Kucukbayrak
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2019)
Review
Materials Science, Multidisciplinary
Melek Erol-Taygun, Irem Unalan, Maizlinda Izwana Binti Idris, Joao F. Mano, Aldo R. Boccaccini
ADVANCED ENGINEERING MATERIALS
(2019)
Article
Materials Science, Composites
Aysen Akturk, Melek Erol Taygun, Gultekin Goller
POLYMER COMPOSITES
(2020)
Article
Materials Science, Multidisciplinary
Aysen Akturk, Funda Karbancioglu Guler, Melek Erol Taygun, Gultekin Goller, Sadriye Kucukbayrak
MATERIALS RESEARCH EXPRESS
(2019)
Article
Engineering, Multidisciplinary
Nuray Yerli-Soylu, Aysen Akturk, Ozlem Kabak, Melek Erol-Taygun, Funda Karbancioglu-Guler, Sadriye Kucukbayrak
Summary: This study synthesized titanium dioxide fibrous nanocomposites doped with silver nanoparticles using sol-gel and electrospinning methods. The resulting nanocomposite membrane exhibited excellent photocatalytic and antibacterial activity after high-temperature calcination.
ENGINEERING SCIENCE AND TECHNOLOGY-AN INTERNATIONAL JOURNAL-JESTECH
(2022)
Article
Chemistry, Multidisciplinary
Baris Demirel, Melek Erol Taygun
Summary: This study aims to produce and characterize glass materials with enhanced antibacterial properties through conventional melting. Various compositions of container glass with different amounts of zinc oxide (ZnO) were prepared and melted to obtain antibacterial glass. Testing showed that the glass doped with 5% ZnO had the most significant antibacterial effect (99.82% Escherichia coli inactivation) and the lowest cost. Physical and mechanical properties of the glass were also evaluated, and the results confirmed its suitability as a glass container. The production of antibacterial glass in regular glass furnaces without any modifications can have significant implications for the pharmaceutical and food industries.
Article
Chemistry, Multidisciplinary
Nuray Yerli Soylu, Anil Soylu, Dilara Nur Dikmetas, Funda Karbancioglu-Guler, Sadriye Kucukbayrak, Melek Erol Taygun
Summary: TiO2-based ceramic nanofiber membranes were synthesized by combining sol-gel and electrospinning processes. The thermal treatment at different temperatures had a significant effect on the properties of the membranes. The nanofiber membranes calcined at 650 and 750 degrees C showed high photocatalytic and antibacterial activities, making them a promising candidate for wastewater treatment.
Article
Chemistry, Multidisciplinary
Baris Demirel, Melek Erol Taygun
Summary: The aim of this study was to produce and characterize borosilicate glass and glass ceramic materials with enhanced antibacterial properties using the conventional melting method. Borosilicate glass doped with ZnO was obtained, and the crystallization temperature was determined for the production of borosilicate glass ceramic doped with ZnO. The antibacterial and leaching tests showed that the glass and glass ceramic doped with 5% ZnO were suitable samples. Physical, thermal, and mechanical properties of the glass and glass ceramic doped with 5% ZnO were also determined. The obtained antibacterial borosilicate glass could be a remarkable product for the pharmaceutical industry, especially for usage in drug packaging.
Article
Chemistry, Multidisciplinary
Aysen Akturk, Funda Nur Kasikci, Dilara Nur Dikmetas, Funda Karbancioglu-Guler, Melek Erol-Taygun
Summary: Recent studies have developed a potential tissue engineering product for wound healing by combining medicinal oils with polymeric scaffolds. Hypericumperforatum oil and vitamin A palmitate were successfully incorporated into gelatin nanofibrous scaffolds. The scaffolds demonstrated favorable microstructure, chemical structure, stability, antibacterial activity, and compatibility with fibroblast cells. These preliminary findings suggest the potential usefulness of this dressing in clinical treatment of skin wounds.
Article
Chemistry, Physical
Baris Demirel, Melek Erol Taygun
Proceedings Paper
Materials Science, Multidisciplinary
M. Erol Taygun, I. Akkaya, S. O. Gonen, S. Kucukbayrak
PROCEEDINGS OF THE 6TH INTERNATIONAL ADVANCES IN APPLIED PHYSICS AND MATERIALS SCIENCE CONGRESS & EXHIBITION (APMAS 2016)
(2017)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
