Article
Dentistry, Oral Surgery & Medicine
Manuel Toledano, Fatima S. Aguilera, Estrella Osorio, Manuel Toledano-Osorio, Germaine Escames, Antonio L. Medina-Castillo, Raquel Toledano, Christopher D. Lynch, Raquel Osorio
Summary: The study investigated the effectiveness of novel polymeric nanoparticles doped with melatonin in reducing dentin permeability and facilitating dentin remineralization after endodontic treatment. Results showed that melatonin-doped nanoparticles effectively sealed dentinal tubules, strengthened the structure of radicular dentin, and promoted durable remineralization. This may provide a new approach for improving root canal treatment outcomes.
Article
Engineering, Biomedical
You Wu, Shoucheng Chen, Pu Luo, Shudan Deng, Zhengjie Shan, Jinghan Fang, Xingchen Liu, Jiaxin Xie, Runheng Liu, Shiyu Wu, Xiayi Wu, Zetao Chen, Kelvin W. K. Yeung, Quan Liu, Zhuofan Chen
Summary: Incorporating zinc-doped nanohydroxyapatite (nZnHA) and cross-linking with alendronate can improve the performance of biogenic collagen membranes, increasing their degradation period and providing good biocompatibility and tissue integration capability.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Siying Tao, Jiaojiao Yang, Zhifei Su, Fangjie Zhou, Ziyou Wang, Yingming Yang, Lizhong Sun, Yi Deng, Kunneng Liang, Jiyao Li
Summary: A new nanomaterial, PAMAM-NGV@galardin, was constructed in this study to induce collagen stabilization and dentin biomimetic remineralization simultaneously, effectively combating early dentin caries.
Article
Biochemistry & Molecular Biology
Jingsi Li, Xiaohan Sun, Jiajia Dai, Jianmin Yang, Liang Li, Zibo Zhang, Jiadong Guo, Shumeng Bai, Yunquan Zheng, Xianai Shi
Summary: A multifunctional hybrid sponge dressing with good wet adhesion was developed by combining biomimetic and enzymatic cross-linking reactions. The dressing exhibited high mechanical properties, antibacterial activity, ROS scavenging, biocompatibility, and excellent hemostasis ability. In vivo studies showed that it could significantly accelerate the healing of infected full-thickness burn wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Lin Tang, Lingli Zhu, Yuhua Liu, Yi Zhang, Bowen Li, Mei Wang
Summary: This study investigated the effects of optimal crosslinking on demineralized dentin matrix and its possible synergism with bionic remineralization using calcium phosphate polymer-induced liquid precursor (CaP-PILP), aiming to improve resin-dentin bonding and dentin hypersensitivity in dental clinical practice. Demineralized dentin was crosslinked with glutaraldehyde (GA), carbodiimide (EDC), and procyanidin (PA) and then subjected to CaP-PILP biomimetic remineralization. The results showed that GA and PA crosslinking preserved the structural integrity, enzyme resistance, and mechanical properties of the collagen fiber network better than EDC and no treatment. PA exhibited the strongest synergistic effects on bionic remineralization by CaP-PILP, significantly improving the quality and shortening the duration of mineralization. These findings have significant implications for resin-dentin bonding and dentin hypersensitivity in dental clinical practice.
Article
Engineering, Biomedical
Jing Guo, Xuedong Shu, Huan Deng, Junwei Zhang, Yao Wang, Guolong Meng, Jing He, Fang Wu
Summary: This study integrates double network cross-linking with enzymatic mineralization to synthesize stiff and tough hydrogels. The synergistic effect of ionic cross-linking and enzymatic mineralization enhances the compressive and tensile stiffness of the hydrogels, as well as the toughness, swelling stability, and cellular response. The mineralized hydrogel cross-linked with Sr2+ shows the highest compressive Young's modulus and exhibits improved cell proliferation, adhesion, and osteogenic differentiation. This research provides an effective approach for preparing hydrogels with osteogenesis and demonstrates their potential in bone tissue engineering applications.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
D. Weiss, M. Latorre, B. Rego, C. Cavinato, B. J. Tanski, A. G. Berman, C. J. Goergen, J. D. Humphrey
Summary: This study investigated the progression of abdominal aortic aneurysms using a mouse model, revealing that loss of elastic fiber integrity is a strong initiator of aneurysms. The research also showed that glycosaminoglycan accumulation is pathologic, not adaptive, and heightened collagen deposition is ineffective if not cross-linked.
ACTA BIOMATERIALIA
(2021)
Review
Engineering, Multidisciplinary
Andrea Butera, Carolina Maiorani, Simone Gallo, Maurizio Pascadopoli, Martina Quintini, Marco Lelli, Fabrizio Tarterini, Ismaela Foltran, Andrea Scribante
Summary: Biomimetic zinc-carbonate hydroxyapatite technology was developed to mimic the natural hydroxyapatite of enamel and dentin and possess strong affinity to adhere to these biological tissues. The literature review showed that oral care products with this technology provide benefits such as remineralization, prevention of enamel demineralization, and reduction of dentinal hypersensitivity.
Article
Biochemistry & Molecular Biology
Agata Sommer, Paulina Dederko-Kantowicz, Hanna Staroszczyk, Slawomir Sommer, Marek Michalec
Summary: This study compares the properties of bacterial cellulose/fish collagen composites (BC/Col) after enzymatic and chemical cross-linking, revealing that enzymatic cross-linking can enhance thermal stability and crystallinity of the material, while oxBC/Col resulting from chemical cross-linking shows lower thermal stability and crystallinity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Yanli Zhao, Shiqi Xue, Xinyue Zhang, Tiehua Zhang, Xue Shen
Summary: The combination of HUS and TGase-mediated cross-linking delays gelation onset, increases gel firmness, improves elasticity and viscosity, enhances water-holding capacity, decreases swelling ratio, and increases gel hardness, cohesiveness, resilience, and chewiness in WPISA-stabilized emulsion gels.
Article
Engineering, Biomedical
S. V. Aruna Rani, K. Rajkumar, B. Saravana Karthikeyan, S. Mahalaxmi, G. Rajkumar, V. Dhivya
Summary: The study aimed to evaluate the remineralization effectiveness of chicken eggshell-derived nanohydroxyapatite (CEnHAp) combined with phytosphingosine (PHS) on artificially induced dentinal lesions. The results showed that dentin treated with CEnHAp-PHS exhibited the highest microhardness values and complete tubular occlusion at all test time intervals.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Viorica Musat, Elena Maria Anghel, Agripina Zaharia, Irina Atkinson, Oana Catalina Mocioiu, Mariana Busila, Petrica Alexandru
Summary: The study successfully developed a biopolymer hydrogel consisting of chitosan and agarose for biomimetic remineralization of acid-etched natural enamel surfaces, resulting in similar hierarchical hydroxyapatite structures similar to natural tooth enamel.
Article
Endocrinology & Metabolism
Aleksandra Mieczkowska, Guillaume Mabilleau
Summary: In this study, a new method for assessing enzymatic cross-link based on FTIR microspectroscopy was proposed, taking into account the secondary structure of type I collagen. The intensities and areas of subbands located at similar to 1660, similar to 1680, and similar to 1690-cm(-1) were found to be positively associated with the concentration of PYD, deoxypyridinoline, or immature dihydroxylysinonorleucine/hydroxylysinonorleucine cross-links. UV exposure and acid treatment significantly reduced the intensity and area of specific subbands. Plod2 and Lox expression were also positively associated with the signal of specific subbands. This method allows for investigation of the tissue distribution of enzymatic cross-links in bone sections.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Review
Pathology
Martin Pehrsson, Joachim Hog Mortensen, Tina Manon-Jensen, Anne-Christine Bay-Jensen, Morten Asser Karsdal, Michael Jonathan Davies
Summary: This review discusses the enzymatic actions of enzymes catalyzing collagen cross-linking and their relevance in organ fibrosis. Additionally, potential biomarkers specifically quantifying proteolytic fragments of collagen cross-linking are explored based on a Pubmed search conducted in November 2020 and the authors' knowledge.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ludan Qin, Shuo Yao, Wenqing Meng, Jiajia Zhang, Ruirui Shi, Chuanjian Zhou, Junling Wu
Summary: This study synthesized dental resin containing silanized hydroxyapatite nanofibers loaded with erythromycin (s-HAFs@EM). The resin exhibited excellent mechanical properties, antibacterial activity, and remineralization capability, making it promising for combating secondary caries.
Article
Chemistry, Multidisciplinary
Wenge Jiang, Haihua Pan, Zhisen Zhang, S. Roger Qiu, J. Dongun Kim, Xurong Xu, Ruikang Tang
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Multidisciplinary Sciences
Chuanlian Xiao, Ming Li, Bingjun Wang, Ming-Feng Liu, Changyu Shao, Haihua Pan, Yong Lu, Bin-Bin Xu, Siwei Li, Da Zhan, Yuan Jiang, Ruikang Tang, Xiang Yang Liu, Helmut Colfen
NATURE COMMUNICATIONS
(2017)
Article
Chemistry, Multidisciplinary
Changyu Shao, Ruibo Zhao, Shuqin Jiang, Shasha Yao, Zhifang Wu, Biao Jin, Yuling Yang, Haihua Pan, Ruikang Tang
ADVANCED MATERIALS
(2018)
Review
Crystallography
Wenjing Jin, Shuqin Jiang, Haihua Pan, Ruikang Tang
Article
Chemistry, Multidisciplinary
Wenjing Jin, Zhaoming Liu, Yuanyuan Wu, Biao Jin, Changyu Shao, Xurong Xu, Ruikang Tang, Haihua Pan
CRYSTAL GROWTH & DESIGN
(2018)
Article
Chemistry, Multidisciplinary
Zhe Wang, Yan Ouyang, Zhifang Wu, Leiqing Zhang, Changyu Shao, Jiayan Fan, Ling Zhang, Ying Shi, Zihuai Zhou, Haihua Pan, Ruikang Tang, Baiping Fu
Article
Multidisciplinary Sciences
Changyu Shao, Biao Jin, Zhao Mu, Hao Lu, Yueqi Zhao, Zhifang Wu, Lumiao Yan, Zhisen Zhang, Yanchun Zhou, Haihua Pan, Zhaoming Liu, Ruikang Tang
Article
Crystallography
Haihua Pan, Ruikang Tang
Article
Multidisciplinary Sciences
Wenjing Jin, Xianfeng Lin, Haihua Pan, Chenchen Zhao, Pengcheng Qiu, Ruibo Zhao, Zihe Hu, Yanyan Zhou, Haiyan Wu, Xiao Chen, Hongwei Ouyang, Zhijian Xie, Ruikang Tang
Summary: The authors demonstrate that chemically engineered osteoclasts coated with tetracycline can improve their targeting capacity to ectopic calcifications, effectively treating heterotopic ossification.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Songzhe Shan, Zhenhang Tang, Kaida Sun, Wenjing Jin, Haihua Pan, Ruikang Tang, Wei Yin, Zhijian Xie, Zhuo Chen, Changyu Shao
Summary: This study proposes a new pathway for collagen fibril mineralization via particle-mediated phase transformation, deepens the understanding of its mechanism, and offers a new strategy for hard tissue repair.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Biomaterials
Wenjing Jin, Yeli Jin, Pengqiang Duan, Haiyan Wu, Leiqing Zhang, Qiaolin Du, Haihua Pan, Ruikang Tang, Changyu Shao
Summary: This study found that succinic acid can significantly promote the mineralization of collagen fibers and accelerate the process of mineralization by interacting with collagen molecules. Demineralized dentin pretreated with succinic acid can be completely remineralized in a shorter time and shows improved mechanical properties.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Zihuai Zhou, Leiqing Zhang, Jiachen Li, Ying Shi, Zhifang Wu, Haiyan Zheng, Zhe Wang, Weijia Zhao, Haihua Pan, Qi Wang, Xiaogang Jin, Xing Zhang, Ruikang Tang, Baiping Fu
Summary: A novel polyelectrolyte-calcium complex pre-precursor (PCCP) process for collagen mineralization was proposed, in which liquid-like electropositive PAsp-Ca complexes infiltrate electronegative collagen fibrils, immobilized within the fibrils via chelation and hydrogen bonds, and prevent outward movement of free calcium ions while recruiting phosphate and hydroxide through electrostatic attractions. This process not only unites two distinct crystallization pathways but also provides a novel strategy for rapid biomimetic mineralization of collagen.
Article
Chemistry, Multidisciplinary
Bo Zheng, Caiyun Mao, Tianyi Gu, Haihua Pan, Changyu Shao, Jian Sun, Chaoqun Chen, Ruikang Tang, Xinhua Gu
NEW JOURNAL OF CHEMISTRY
(2019)
Article
Nanoscience & Nanotechnology
Zhifang Wu, Xiaokan Wang, Zhe Wang, Changyu Shao, Xiaoting Jin, Leiqing Zhang, Haihua Pan, Ruikang Tang, Baiping Fu
ACS APPLIED MATERIALS & INTERFACES
(2017)
Review
Chemistry, Multidisciplinary
Yuanyuan Wu, Haihua Pan, Ruikang Tang
PROGRESS IN CHEMISTRY
(2018)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)