Article
Engineering, Multidisciplinary
Yuhui Qiao, Qian Li, Amirjalal Jalali, Jinian Yang, Xiaofeng Wang, Na Zhao, Yongchao Jiang, Shiwei Wang, Jianhua Hou, Jing Jiang
Summary: The study found that the fibrillated PCL/PLA composites formed a 3D network of PLA fibers after hot-stretching, increasing the viscosity and storage modulus of the materials, and exhibited a solid-like behavior.
COMPOSITES PART B-ENGINEERING
(2021)
Article
Materials Science, Textiles
Bakhshali Massoumi, Mojtaba Abbasian, Balal Khalilzadeh, Rana Jahanban-Esfahlan, Hadi Samadian, Hossein Derakhshankhah, Mehdi Jaymand
Summary: Two novel electrically conductive nanofibrous scaffolds based on chitosan-grafted polythiophene (CS-g-PTh) and chitosan-grafted polythiophene/poly(epsilon-caprolactone) (CS-g-PTh/PCL) were fabricated using electrospinning technique, showing good biological compatibility, conductivity, and cell proliferation. The CS-g-PTh/PCL scaffold exhibited slightly higher cell proliferation than the CS-g-PTh scaffold within 7 days.
FIBERS AND POLYMERS
(2021)
Article
Polymer Science
Moloud A. Baghbadorani, Ashkan Bigham, Mohammad Rafienia, Hossein Salehi
Summary: In this study, a novel nanocomposite fibrous scaffold composed of PCL/GT/GLN7% was fabricated through electrospinning method, and its potential for bone tissue regeneration was evaluated through various physical and chemical properties assessments in vitro. The results indicate that the ternary scaffold shows promising performance in accelerating cell attachment, proliferation, and differentiation rate for bone tissue regeneration.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Cell Biology
David S. Ruppert, Mahmoud M. Mohammed, Mohamed M. Ibrahim, Emilio O. Bachtiar, Kevin Erning, Kayvan Ansari, Jeffrey I. Everitt, David Brown, Bruce Klitzman, William Koshut, Ken Gall, Howard Levinson
Summary: This study demonstrates the use of a slow-degrading viscoelastic copolymer, poly(1-lactide-co-epsilon-caprolactone), to manufacture tissue engineered scaffolds that promote tissue ingrowth and support skin-grafts. The scaffolds have been shown to be safe and effective in mouse and swine wound models, potentially offering an alternative technology for supporting skin grafts and investigating long-term hypertrophic scar contractures.
WOUND REPAIR AND REGENERATION
(2021)
Article
Materials Science, Biomaterials
Xiaoxiao Wang, Jing Liu, Huimin Jing, Binhan Li, Zhiting Sun, Boxuan Li, Deling Kong, Xigang Leng, Zhihong Wang
Summary: This study fabricated electrospun scaffolds with different ratios of PLCL and SF for tissue engineered heart valve application. The PLCL/SF scaffolds of 80/20 ratio showed the best cytocompatibility and anti-calcification ability, demonstrating great potential as TEHV materials.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Cell & Tissue Engineering
Reetta Sartoneva, Kaarlo Paakinaho, Markus Hannula, Kirsi Kuismanen, Heini Huhtala, Jari Hyttinen, Susanna Miettinen
Summary: This study evaluated the effect of A2P on vaginal tissue engineering for the first time and the results are highly encouraging. The scPLCL(A2P) scaffold showed potential as a scaffold for vaginal tissue engineering, promoting the viability, proliferation, and collagen production of vaginal cells.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2023)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)