Article
Biochemistry & Molecular Biology
Zhiwei Zheng, Xiaobo Li, Pan Chen, Yu Zou, Xiaojian Shi, Xiang Li, Eun Young Kim, Jing Liao, Jun Yang, Nipon Chattipakorn, Gaojun Wu, Qidong Tang, Won-Jea Cho, Guang Liang
Summary: A series of diimide indole derivatives were designed and synthesized to treat acute lung injury. Some of these compounds showed good anti-inflammatory activity and were able to alleviate lung damage. These findings suggest that these novel diimide indoles have potential value for the treatment of acute lung injury.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yang Wang, Qing Li, Mengsheng Deng, Kuijun Chen, Jianmin Wang
Summary: Metal-organic frameworks (MOFs) have shown great potential in various fields, including nanotechnology and biomedical applications. In this study, zeolite imidazole skeleton-8 (ZIF-8) was used as a drug carrier for the treatment of lung injury. The results demonstrated that ZIF-8 encapsulating plumbagin (PLB) effectively reduced collagen fibers deposition and decreased the secretion of inflammatory factors in a severe lung injury animal model. This research presents a promising strategy for the application of MOF materials in the biomedical field.
CHINESE CHEMICAL LETTERS
(2022)
Review
Nanoscience & Nanotechnology
Shuai Bian, Hongfei Cai, Youbin Cui, Wanguo Liu, Chunsheng Xiao
Summary: ALI and ARDS can cause life-threatening respiratory failure with a high mortality rate. Despite some clinical interventions, there is still no completely effective treatment for ALI. Recent advances in nanotechnology may provide new possibilities for the pharmacotherapy of ALI.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Xiemin Wang, Jun Yang, Bingyu Ding, Pan Chen, Zhengwei Xu, Yunxi Zhao, Pengqin Chen, Nipon Chattipakorn, Guang Liang, Di Wu, Qidong Tang
Summary: This study successfully synthesized a series of fisetin derivatives which showed promising anti-inflammatory activities, with compound 5b demonstrating significant in vivo efficacy in a mouse model of LPS-induced ALI. These findings suggest that natural products could be a valuable source for the discovery of new drugs for ALI treatment.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Tianpeng Chen, Yingying Wei, Gaoyang Zhu, Huajun Zhao, Xingxian Zhang
Summary: A series of novel compounds were designed to inhibit acute lung injury, among which compound 6h showed superior activity in reducing inflammatory response and protecting lung tissue.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Dan-Li Hao, Ya-Jie Wang, Jia-Ying Yang, Ran Xie, Ling-Yu Jia, Jin-Tang Cheng, Hai Ma, Ji-Xiang Tian, Shan-Shan Guo, Ting Liu, Feng Sui, Yu Zhao, Yan-Jun Chen, Qing-He Zhao
Summary: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common clinical syndromes that can lead to severe respiratory failure and high mortality. Nanotechnology-mediated anti-inflammatory therapy is a promising approach for ALI treatment. This study demonstrated that the artesunate prodrugs can effectively attenuate LPS-induced ALI, suggesting a novel strategy for treating inflammation-induced lung injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Di Liang, Wanmei Wang, Guangrui Chen, Jian Li, Guifang Dou, Hui Gan, Peng Han, Lina Du, Ruolan Gu
Summary: SARS-CoV-2 induces a severe cytokine storm that can cause acute lung injury/acute respiratory distress syndrome (ARDS). In this study, we developed dry powder inhalers (DPI) for the treatment of acute lung injury (ALI) in rats. CEP dry powder inhalers showed promising results in reducing pulmonary edema and inflammation.
Article
Chemistry, Medicinal
Pan Chen, Jun Yang, Ying Zhou, Xiaobo Li, Yu Zou, Zhiwei Zheng, Mi Guo, Zhichao Chen, Won-Jea Cho, Nipon Chattipakorn, Wenqi Wu, Qidong Tang, Guang Liang
Summary: The uneven regulation of inflammation is related to various diseases, and anti-inflammation shows potential for the development of novel therapies. In this study, a series of novel amide/sulfonamide derivatives were designed and synthesized. Compound 11d exhibited strong anti-inflammatory activities through the inhibition of IL-6 and TNF-alpha and the modulation of cellular signaling pathways. In vivo studies demonstrated that compound 11d improved LPS-induced ALI and alleviated DSS-induced ulcerative colitis in mice.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Zhiyue Li, Xueqin Yan, Jiangchun Wei, Liuyang Pu, Guanbao Zhu, Yongkai Cao, Zhanyan Liu, Yaqian Liu, Yan Li, Limin Li, Xinping Li, Zhengzhi Wu
Summary: A novel compound called colchicine-myricetin hybrid (CMyrH) was synthesized and shown to effectively protect cells from acute lung injury, reduce lung damage and inflammation in rats. Furthermore, the compound was found to inhibit apoptosis-related proteins and bind strongly to human neutrophil elastase. Overall, this study highlights the potential therapeutic application of CMyrH in treating acute lung injury.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Radostina Kalinova, Ivaylo Dimitrov
Summary: This study constructed and evaluated novel polymeric nanosized drug carriers with tunable surface charges. The promising candidates for potential application in nanomedicine were identified.
Review
Pharmacology & Pharmacy
Makhloufi Zoulikha, Qingqing Xiao, George Frimpong Boafo, Marwa A. Sallam, Zhongjian Chen, Wei He
Summary: siRNA has potential for treating acute lung injury/acute respiratory distress syndrome by modifying gene expression, but effective delivery remains a challenge.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Pharmacology & Pharmacy
Meiling Su, Bowen Yang, Mingrong Xi, Cheng Qiang, Zongning Yin
Summary: The study prepared DXM/PEI/mannose prodrug nanoparticles with good targeting and therapeutic effects for the treatment of ALI, showing sensitivity to the micro-acid environment and significant in vitro targeting of mouse mononuclear macrophages, as well as good anti-inflammatory activity and long-term lung targeting effect in vivo.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Siyu He, Li Wu, Hongyu Sun, Di Wu, Caifen Wang, Xiaohong Ren, Qun Shao, Peter York, Jiabing Tong, Jie Zhu, Zegeng Li, Jiwen Zhang
Summary: This study developed a novel ROS-responsive inhalable particulate carrier (OC-COF) for improved treatment of acute lung injury (ALI). The carrier can deliver drugs specifically to the deep alveolar regions of the lungs, and has antioxidant and anti-inflammatory activities. In in vivo experiments, Ligustrazine (LIG) loaded in OC-COF significantly alleviated inflammation, oxidant stress, and lung damage. This study provides a new ROS-responsive material as an inhalable particulate carrier for the treatment of ALI and other medical conditions.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Xianglong Kong, Nan Zhang, Huaxing Shen, Nan Wang, Wei Cong, Chao Liu, Hong-gang Hu
Summary: In this study, stapled peptides based on Ascaphin-8 were designed and synthesized using thiol-halogen click chemistry. Most of the modified peptide derivatives showed enhanced antitumor activity, among which A8-2-o and A8-4-Dp exhibited the best structural stability, hydrolytic enzyme tolerance, and biological activity. This research may serve as a reference for the stapled modification of other similar natural antimicrobial peptides.
Article
Chemistry, Multidisciplinary
Manuel G. Ricardo, Emelie E. Reuber, Ling Yao, Jose Danglad-Flores, Martina Delbianco, Peter H. Seeberger
Summary: This article describes the design, synthesis, and characterization of the first stapled oligosaccharides, which increases enzymatic stability and cell penetration by applying the concept of stapling short peptides to oligosaccharides.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Ali Mehri, Karim Mahnam, Hajar Sirous, Mahmoud Aghaei, Leila Rafiei, Mahboubeh Rostami
Summary: One potential approach for tumor therapy is inhibiting the binding between MDM2 and p53 to reactivate p53 in tumor cells. In this study, Monastrol derivatives were designed as MDM2 inhibitors and evaluated for their cytotoxicity on cancer cells. Compound 5d showed the best inhibitory results in silico and in vitro experiments. These findings suggest that Monastrol derivatives have the potential to be candidates for MDM2 inhibition.
CHEMICAL BIOLOGY & DRUG DESIGN
(2024)