Article
Engineering, Biomedical
Xue Dong, Ishani D. Premaratne, Kemal Sariibrahimoglu, Skander Limem, Jeffrey Scott, Mariam Gadjiko, Nabih Berri, Paula Ginter, Jason A. Spector
Summary: The use of 3D-printed P4HB nipple reconstruction scaffold filled with patient-derived CC or with an internal 3D lattice of P4HB filaments can promote tissue ingrowth and protect regenerated tissue. It shows potential in maintaining projection and approximating the biomechanical properties of the native human nipple.
ACTA BIOMATERIALIA
(2022)
Article
Materials Science, Multidisciplinary
Yadong Wu, Miaomiao Jin, Yudong Huang, Fang Wang
Summary: Tissue engineering is an emergent interdisciplinary subject that is extensively used in the maintenance, repair, replacement, and reconstruction of various tissues and organs. This study focuses on the synthesis of a composite aerogel material, ANFs/CHi/GA, for tissue engineering scaffolds. The composite material exhibits bacteriostatic properties, and cells adhere and distribute well on its surface, making it suitable for scaffold applications.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Yadong Wu, Miaomiao Jin, Yudong Huang, Fang Wang
Summary: Tissue engineering, as an interdisciplinary subject, is widely used in the maintenance, repair, replacement, and reconstruction of various tissues such as cartilage, blood vessels, heart, skin, and liver. This study introduces a composite aerogel made from chitosan and aramid fibers, which exhibits excellent biocompatibility and antibacterial properties, making it suitable for scaffold materials in tissue engineering.
ACS APPLIED POLYMER MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Sanaz Soleymani Eil Bakhtiari, Saeed Karbasi, Elahe Bahremandi Toloue
Summary: As a member of the PHAs family, PHB has desirable properties for various medical applications, including high biocompatibility, non-toxic degradation products, and high mechanical strength. Different approaches such as PHB alloy scaffolds and composite scaffolds are used to improve its properties in tissue engineering applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biology
Asiyah Esmail, Joao R. Pereira, Chantal Sevrin, Christian Grandfils, Ugur Deneb Menda, Elvira Fortunato, Abel Oliva, Filomena Freitas
Summary: The study investigated the processing of poly(hydroxyalkanoates) (PHAs) for porous scaffolds, with emulsion templating technique showing a good balance between porosity and hydrophilicity while maintaining mechanical properties. The copolymer P(3HB-co-3HV) exhibited the best overall performance, with lower crystallinity and higher flexibility.
Article
Chemistry, Applied
Yao Du, Dawei Zhao, Yimei Liu, Kai Chen, Tao Wang
Summary: In this study, a bioactive fluorescence dye was prepared by coupling collagen type I and Cyanine IR-780 (Cyan) using dihydrolipoic acid (DHLA). The dye showed light stability under 405 nm LED light source and can be used in digital light processing-3D printing to fabricate hydrogel scaffolds containing bone collagen with fluorescent properties. The retained SH group in this dye can participate in the polymerization reaction and improve the photopolymerization speed, while exhibiting fluorescence enhancement and anti-aggregation quenching effect.
Article
Biochemistry & Molecular Biology
C. Uitz Toala, E. Prokhorov, G. Luna Barcenas, M. A. Hernandez Landaverde, J. M. Yanez Limon, J. J. Gervacio-Arciniega, O. Arias de Fuentes, A. M. Garay Tapia
Summary: In this study, chitosan-poly(3-hydroxybutyrate) (CS-PHB) blend films with high apparent piezoelectric coefficient were reported. The structure of CS-PHB blend films, including the dielectric, polarization, and apparent piezoelectric properties, as well as their dependencies on composition, was investigated. The results suggest that the synergistic effects of piezoelectricity and electrostriction contribute to the high value of the apparent piezoelectric coefficient obtained in the blend film.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Marius Stelian Popa, Adriana Nicoleta Frone, Ionut Cristian Radu, Paul Octavian Stanescu, Roxana Trusca, Valentin Raditoiu, Cristian Andi Nicolae, Augusta Raluca Gabor, Denis Mihaela Panaitescu
Summary: This work proposes a new method for obtaining PHB/MC composites with more balanced properties by adjusting the surface of MC to enhance its compatibility with the PHB matrix. The modified celluloses showed good thermal stability and acted as nucleating agents in PHB, increasing its crystallinity. The dual role of the SIMA-MA treatment as both compatibilizer and plasticizer was highlighted through mechanical and rheological measurements.
Article
Polymer Science
Mat Junoh Azuraini, Sevakumaran Vigneswari, Kai-Hee Huong, Wan M. Khairul, Abdul H. P. S. Khalil, Seeram Ramakrishna, Al-Ashraf Abdullah Amirul
Summary: In this study, sponge-like porous scaffolds for medical applications were successfully prepared. The introduction of gelatine into PHB helped improve the physical and biological properties of the blend scaffolds. The 0.4g-(P50mol%G10) scaffold showed great potential due to its unique structure and properties.
Article
Environmental Sciences
Deepak Verma, Nichakan Nichakornpong, Unchalee Kraiwitwattana, Manunya Okhawilai, Pornnapa Kasemsiri, Pranut Potiyaraj, Ratthapol Rangkupan
Summary: In this study, a PM2.5 dust filter was developed using the electrospinning technique with a biopolymer called poly(3-hydroxybutyrate) (PHB). The filter showed high filtration efficiency and tensile strength, making it a potential candidate for PM2.5 filtration membrane production.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Alberto Giubilini, Massimo Messori, Federica Bondioli, Paolo Minetola, Luca Iuliano, Gustav Nystro''m, Katharina Maniura-Weber, Markus Rottmar, Gilberto Siqueira
Summary: While biomaterials are crucial for tissue repair, the removal of non-bio-based and non-bioresorbable scaffolds often leads to negative consequences for patients and the healthcare system. The use of new biopolymers in tissue regeneration is limited due to mechanical and biological challenges. However, incorporating reinforcing agents into biopolymers can enhance their properties. This study focused on developing a bio-based and bioresorbable composite material by combining PHBH with CNCs, demonstrating its printability and cytocompatibility, and showing the influence of CNC content on the functional properties of the scaffolds. Tailoring the properties of PHBH with CNCs expands its potential for tissue engineering applications.
Article
Polymer Science
Rushabh Patel, Davide Monticone, Mingyuan Lu, Lisbeth Grondahl, Han Huang
Summary: The long-term hydrolytic degradation of SLS PHBV bone scaffolds was explored by incubating them in PBS solution for 20 weeks. The degradation occurred predominantly by bulk degradation, leading to reduction in molecular weight and compressive stiffness while increasing crystallinity. The weight loss was minimal in the first 8 weeks, with gradual increase thereafter, and the concentration of COOH groups on the scaffold surface initially increased before declining due to surface erosion from hydrolysis.
POLYMER DEGRADATION AND STABILITY
(2021)
Review
Polymer Science
Yuliya Zhuikova, Vsevolod Zhuikov, Valery Varlamov
Summary: The development of modern medical devices focuses on finding and creating new materials with better properties. Natural biopolymers, such as polyhydroxyalkanoates and polysaccharides, show potential in various applications. This article describes the properties of these biopolymers and explores the creation of polymer composites to overcome their drawbacks.
Article
Polymer Science
Shohei Yamazaki, Keiichiro Yoshida, Hidetoshi Matsumoto, Masatoshi Tokita
Summary: This study demonstrated the realization of a graphitic structure through low-temperature carbonization of poly(acrylonitrile) (PAN) grafted onto nanoparticle surfaces, highlighting the necessity of dense PAN chain grafting for lower-temperature graphitization.
Article
Polymer Science
Sandra Garcia-Cerna, Uriel Sanchez-Pacheco, Angelica Meneses-Acosta, Jose Rojas-Garcia, Bernardo Campillo-Illanes, Daniel Segura-Gonzalez, Carlos Pena-Malacara
Summary: This study developed P3HB scaffolds using 3D printing and evaluated their biocompatibility with HaCaT epidermal cells. The scaffold, obtained through a simplified extraction method, showed no cytotoxicity and allowed high cell proliferation, indicating its potential as a biomatrix for tissue engineering.
