4.4 Article

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Chemical Biology & Drug Design
Volume 85, Issue 3, Pages -

Publisher

Wiley
DOI: 10.1111/cbdd.2015.85.issue-3

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Article Biochemistry & Molecular Biology

Dihydropyrimidine derivatives as MDM2 inhibitors

Ali Mehri, Karim Mahnam, Hajar Sirous, Mahmoud Aghaei, Leila Rafiei, Mahboubeh Rostami

Summary: One potential approach for tumor therapy is inhibiting the binding between MDM2 and p53 to reactivate p53 in tumor cells. In this study, Monastrol derivatives were designed as MDM2 inhibitors and evaluated for their cytotoxicity on cancer cells. Compound 5d showed the best inhibitory results in silico and in vitro experiments. These findings suggest that Monastrol derivatives have the potential to be candidates for MDM2 inhibition.

CHEMICAL BIOLOGY & DRUG DESIGN (2024)