Synthesis and Evaluation of Millepachine Amino Acid Prodrugs With Enhanced Solubility as Antitumor Agents

Design, synthesis and biological evaluation of a series of pyrano chalcone derivatives containing indole moiety as novel anti-tubulin agents

(2014) Guangcheng Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

STAT3-Mediated Autophagy Dependence Identifies Subtypes of Breast Cancer Where Autophagy Inhibition Can Be Efficacious

(2014) P. Maycotte et al.   CANCER RESEARCH

Novel Colchicine-Site Binders with a Cyclohexanedione Scaffold Identified through a Ligand-Based Virtual Screening Approach

(2014) María-Dolores Canela et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting Microtubules by Natural Agents for Cancer Therapy

(2014) E. Mukhtar et al.   MOLECULAR CANCER THERAPEUTICS

Design, synthesis and biological evaluation of millepachine derivatives as a new class of tubulin polymerization inhibitors

(2013) Guangcheng Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Taccalonolide Binding to Tubulin Imparts Microtubule Stability and Potent In Vivo Activity

(2013) A. L. Risinger et al.   CANCER RESEARCH

Millepachine, a novel chalcone, induces G 2 /M arrest by inhibiting CDK1 activity and causing apoptosis via ROS-mitochondrial apoptotic pathway in human hepatocarcinoma cells in vitro and in vivo

(2013) Wenshuang Wu et al.   CARCINOGENESIS

Phase I Safety, Pharmacokinetic and Pharmacodynamic Evaluation of the Vascular Disrupting Agent Ombrabulin (AVE8062) in Patients with Advanced Solid Tumors

(2013) C. Sessa et al.   CLINICAL CANCER RESEARCH

Synthesis and biological evaluation of novel pyranochalcone derivatives as a new class of microtubule stabilizing agents

(2013) Dong Cao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and structure–activity relationship studies of novel millepachine derivatives as potent antiproliferative agents

(2012) Guangcheng Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cytotoxic and apoptotic effects of constituents from Millettia pachycarpa Benth

(2012) Haoyu Ye et al.   FITOTERAPIA

Increased Bioavailability of Tricin−Amino Acid Derivatives via a Prodrug Approach

(2011) Masayuki Ninomiya et al.   JOURNAL OF MEDICINAL CHEMISTRY

Triple-negative breast cancer--current status and future directions

(2009) O. Gluz et al.   ANNALS OF ONCOLOGY

In vitro solubility, stability and permeability of novel quercetin–amino acid conjugates

(2008) Mi Kyoung Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Effect of non-essential amino acid glycine administration on the liver regeneration of partially hepatectomized rats with hepatic ischemia/reperfusion injury

(2008) Koji Ito et al.   CLINICAL NUTRITION