Natural Products from Microalgae with Potential against Alzheimer’s Disease: Sulfolipids Are Potent Glutaminyl Cyclase Inhibitors

TOXIC PGLU-ABETA IS ENHANCED AND GLUTAMINYL CYCLASE (QC) UP-REGULATED EARLY IN ALZHEIMER'S DISEASE (AD): INHIBITORS OF QC BLOCKING PGLU-ABETA FORMATION ARE IN CLINICAL DEVELOPMENT

(2014) Hans-Ulrich Demuth et al.   Alzheimers & Dementia

Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC

(2014) Corinna Höfling et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Telomerase Inhibitors from Cyanobacteria: Isolation and Synthesis of Sulfoquinovosyl Diacylglycerols fromMicrocystis aeruguinosaPCC 7806

(2013) Malika Makhlouf Brahmi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fatty acid neutral losses observed in tandem mass spectrometry with collision-induced dissociation allows regiochemical assignment of sulfoquinovosyl-diacylglycerols

(2013) Rosalia Zianni et al.   JOURNAL OF MASS SPECTROMETRY

Pyroglutamate Amyloid-β (Aβ): A Hatchet Man in Alzheimer Disease

(2011) Sadim Jawhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of sulfoquinovosyldiacyglycerides from Phaeodactylum tricornutum by matrix-assisted laser desorption/ionization QTrap time-of-flight hybrid mass spectrometry

(2011) Ivonne Naumann et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Inhibition of Glutaminyl Cyclase: Pharmacology and steps towards clinical development

(2010) Hans-Ulrich Demuth et al.   Alzheimers & Dementia

Global characterization of the photosynthetic glycerolipids from a marine diatom Stephanodiscus sp. by ultra performance liquid chromatography coupled with electrospray ionization-quadrupole-time of flight mass spectrometry

(2010) Jilin Xu et al.   ANALYTICA CHIMICA ACTA

Identification of a sulfonoquinovosyldiacylglyceride from Azadirachta indica and studies on its cytotoxic activity and DNA binding properties

(2010) Ratna Chatterjee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Overexpression of Glutaminyl Cyclase, the Enzyme Responsible for Pyroglutamate Aβ Formation, Induces Behavioral Deficits, and Glutaminyl Cyclase Knock-out Rescues the Behavioral Phenotype in 5XFAD Mice

(2010) Sadim Jawhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitors for Human Glutaminyl Cyclase by Structure Based Design and Bioisosteric Replacement

(2009) Mirko Buchholz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Amyloidogenic Processing of Amyloid Precursor Protein: Evidence of a Pivotal Role of Glutaminyl Cyclase in Generation of Pyroglutamate-Modified Amyloid-β†

(2008) Holger Cynis et al.   BIOCHEMISTRY

Inhibition of glutaminyl cyclase prevents pGlu-A formation after intracorticalhippocampal microinjectionin vivoin situ

(2008) Stephan Schilling et al.   JOURNAL OF NEUROCHEMISTRY

Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology

(2008) Stephan Schilling et al.   NATURE MEDICINE