A Coral-Derived Compound Improves Functional Recovery after Spinal Cord Injury through Its Antiapoptotic and Anti-Inflammatory Effects

The role of the PI3K/Akt/mTOR pathway in glial scar formation following spinal cord injury

(2016) Chun-Hong Chen et al.   EXPERIMENTAL NEUROLOGY

Simvastatin inhibits neural cell apoptosis and promotes locomotor recovery via activation of Wnt/β-catenin signaling pathway after spinal cord injury

(2016) Kai Gao et al.   JOURNAL OF NEUROCHEMISTRY

Cyclic AMP is a key regulator of M1 to M2a phenotypic conversion of microglia in the presence of Th2 cytokines

(2016) Mousumi Ghosh et al.   Journal of Neuroinflammation

Neuron-derived FGF10 ameliorates cerebral ischemia injury via inhibiting NF-κB-dependent neuroinflammation and activating PI3K/Akt survival signaling pathway in mice

(2016) Yong-Hua Li et al.   Scientific Reports

Xuefu Zhuyu decoction, a traditional Chinese medicine, provides neuroprotection in a rat model of traumatic brain injury via an anti-inflammatory pathway

(2016) Zhihua Xing et al.   Scientific Reports

The Neuroprotection of Liraglutide Against Ischaemia-induced Apoptosis through the Activation of the PI3K/AKT and MAPK Pathways

(2016) Huili Zhu et al.   Scientific Reports

Crosstalk Between MAPK/ERK and PI3K/AKT Signal Pathways During Brain Ischemia/Reperfusion

(2015) Jing Zhou et al.   ASN Neuro

The use of the antimicrobial peptide piscidin (PCD)-1 as a novel anti-nociceptive agent

(2015) Wu-Fu Chen et al.   BIOMATERIALS

Neuroprotective Effects of Direct Intrathecal Administration of Granulocyte Colony-Stimulating Factor in Rats with Spinal Cord Injury

(2015) Wu-Fu Chen et al.   CNS Neuroscience & Therapeutics

Involvement of phosphatase and tensin homolog deleted from chromosome 10 in rodent model of neuropathic pain

(2015) Shi-Ying Huang et al.   Journal of Neuroinflammation

Anti-Inflammatory and Analgesic Effects of the Marine-Derived Compound Excavatolide B Isolated from the Culture-Type Formosan Gorgonian Briareum excavatum

(2015) Yen-You Lin et al.   Marine Drugs

Overexpressing neuroglobin improves functional recovery by inhibiting neuronal apoptosis after spinal cord injury

(2014) Wen-Bin Lan et al.   BRAIN RESEARCH

Neuroprotective and anti-apoptotic effects of valproic acid on adult rat cerebral cortex through ERK and Akt signaling pathway at acute phase of traumatic brain injury

(2014) Chi Zhang et al.   BRAIN RESEARCH

Flexibilide Obtained from Cultured Soft Coral Has Anti-Neuroinflammatory and Analgesic Effects through the Upregulation of Spinal Transforming Growth Factor-β1 in Neuropathic Rats

(2014) Nan-Fu Chen et al.   Marine Drugs

Marketed Marine Natural Products in the Pharmaceutical and Cosmeceutical Industries: Tips for Success

(2014) Ana Martins et al.   Marine Drugs

Aldose Reductase Regulates Microglia/Macrophages Polarization Through the cAMP Response Element-Binding Protein After Spinal Cord Injury in Mice

(2014) Qian Zhang et al.   MOLECULAR NEUROBIOLOGY

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Apelin-13 protects the brain against ischemia/reperfusion injury through activating PI3K/Akt and ERK1/2 signaling pathways

(2014) Yi Yang et al.   NEUROSCIENCE LETTERS

Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro

(2013) Vibol Chhor et al.   BRAIN BEHAVIOR AND IMMUNITY

Intrathecal Epigallocatechin Gallate Treatment Improves Functional Recovery After Spinal Cord Injury by Upregulating the Expression of BDNF and GDNF

(2013) Wei Tian et al.   NEUROCHEMICAL RESEARCH

Granulocyte colony-stimulating factor improves alternative activation of microglia under microenvironment of spinal cord injury

(2013) Y. Guo et al.   NEUROSCIENCE

Coral aquaculture to support drug discovery

(2013) Miguel C. Leal et al.   TRENDS IN BIOTECHNOLOGY

Minocycline selectively inhibits M1 polarization of microglia

(2013) K Kobayashi et al.   Cell Death & Disease

Electroacupuncture at Quchi and Zusanli treats cerebral ischemia-reperfusion injury through activation of ERK signaling

(2013) GUANLI XIE et al.   Experimental and Therapeutic Medicine

Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia

(2012) Jason Howitt et al.   JOURNAL OF CELL BIOLOGY

CREB-mediated Bcl-2 expression contributes to RCAN1 protection from hydrogen peroxide-induced neuronal death

(2012) Seon Sook Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Blockade of interleukin-6 signaling inhibits the classic pathway and promotes an alternative pathway of macrophage activation after spinal cord injury in mice

(2012) Alexander Rodriguez Guerrero et al.   Journal of Neuroinflammation

Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury

(2012) Atsushi Sato et al.   Journal of Neuroinflammation

Systemic Bisperoxovanadium Activates Akt/mTOR, Reduces Autophagy, and Enhances Recovery following Cervical Spinal Cord Injury

(2012) Chandler L. Walker et al.   PLoS One

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Marine natural products: a new wave of drugs?

(2011) Rana Montaser et al.   Future Medicinal Chemistry

Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice

(2011) Carlo Perego et al.   Journal of Neuroinflammation

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

(2011) Adam D Bachstetter et al.   Journal of Neuroinflammation

Docosahexaenoic Acid Pretreatment Confers Protection and Functional Improvements after Acute Spinal Cord Injury in Adult Rats

(2011) Johnny D. Figueroa et al.   JOURNAL OF NEUROTRAUMA

Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system

(2011) W. Liu et al.   LIFE SCIENCES

Repertoire of microglial and macrophage responses after spinal cord injury

(2011) Samuel David et al.   NATURE REVIEWS NEUROSCIENCE

Neuroprotection by marine-derived compound, 11-dehydrosinulariolide, in an in vitro Parkinson’s model: a promising candidate for the treatment of Parkinson’s disease

(2011) Wu-Fu Chen et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Tumor Necrosis Factor-α Antagonist Reduces Apoptosis of Neurons and Oligodendroglia in Rat Spinal Cord Injury

(2011) Ke-Bing Chen et al.   SPINE

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Marine natural products as sources of novel scaffolds: achievement and concern

(2010) De-Xin Kong et al.   DRUG DISCOVERY TODAY

Inhibition of Apoptotic Cell Death by Ghrelin Improves Functional Recovery after Spinal Cord Injury

(2010) Jee Y. Lee et al.   ENDOCRINOLOGY

Synergistic activity of interleukin-17 and tumor necrosis factor-α enhances oxidative stress-mediated oligodendrocyte apoptosis

(2010) Manjeet K. Paintlia et al.   JOURNAL OF NEUROCHEMISTRY

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Restoration of Akt activity by the bisperoxovanadium compound bpV(pic) attenuates hippocampal apoptosis in experimental neonatal pneumococcal meningitis

(2010) Matthias D. Sury et al.   NEUROBIOLOGY OF DISEASE

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Anti-TNF therapy in the injured spinal cord

(2010) Emanuela Esposito et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Non-receptor tyrosine kinase Src is required for ischemia-stimulated neuronal cell proliferation via Raf/ERK/CREB activation in the dentate gyrus

(2009) He-Ping Tian et al.   BMC NEUROSCIENCE

Overcoming Macrophage-Mediated Axonal Dieback Following CNS Injury

(2009) S. A. Busch et al.   JOURNAL OF NEUROSCIENCE

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

Reduced neurogenesis after suppressed inflammation by minocycline in transient cerebral ischemia in rat

(2009) Beom Joon Kim et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Microglial Involvement in Neuroplastic Changes Following Focal Brain Ischemia in Rats

(2009) Alexandre Madinier et al.   PLoS One

A CREB-C/EBP  cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair

(2009) D. Ruffell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor Necrosis Factor-Alpha and Its Receptors Contribute to Apoptosis of Oligodendrocytes in the Spinal Cord of Spinal Hyperostotic Mouse (twy/twy) Sustaining Chronic Mechanical Compression

(2009) Tomoo Inukai et al.   SPINE

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

Estrogen-Induced Bcl-2 Expression after Spinal Cord Injury Is Mediated through Phosphoinositide-3-Kinase/Akt-Dependent CREB Activation

(2008) Tae Y. Yune et al.   JOURNAL OF NEUROTRAUMA

Intrathecally injected granulocyte colony-stimulating factor produced neuroprotective effects in spinal cord ischemia via the mitogen-activated protein kinase and Akt pathways

(2008) W.-F. Chen et al.   NEUROSCIENCE

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression

(2008) Hui-Ming Gao et al.   TRENDS IN IMMUNOLOGY

CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure

(2007) Michael T. Fitch et al.   EXPERIMENTAL NEUROLOGY