Journal
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
Volume 29, Issue 3, Pages 617-639Publisher
SPRINGER
DOI: 10.1007/s10334-016-0561-4
Keywords
Magnetic resonance imaging; Ultrahigh magnetic fields; High temperature superconductors; Diffusion tensor imaging; Parallel transmit and receive strategies; Human brain chemistry; Magnetic field physiologic effects
Funding
- NIBIB NIH HHS [P41 EB017183] Funding Source: Medline
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An initiative to design and build magnetic resonance imaging (MRI) and spectroscopy (MRS) instruments at 14 T and beyond to 20 T has been underway since 2012. This initiative has been supported by 22 interested participants from the USA and Europe, of which 15 are authors of this review. Advances in high temperature superconductor materials, advances in cryocooling engineering, prospects for non-persistent mode stable magnets, and experiences gained from large-bore, high-field magnet engineering for the nuclear fusion endeavors support the feasibility of a human brain MRI and MRS system with 1 ppm homogeneity over at least a 16-cm diameter volume and a bore size of 68 cm. Twelve neuroscience opportunities are presented as well as an analysis of the biophysical and physiological effects to be investigated before exposing human subjects to the high fields of 14 T and beyond.
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