Article
Radiology, Nuclear Medicine & Medical Imaging
Bingjie Yang, Patrick Metze, Anke Balasch, Kilian Stumpf, Meinrad Beer, Wolfgang Rottbauer, Volker Rasche
Summary: This study evaluated the reproducibility of lung function parameters in healthy subjects using 2D UTE and tyGA ordering, showing that functional parameters derived from FB acquisitions are reproducible. BH acquisitions had larger breathing amplitudes and lower reproducibility.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Physics, Multidisciplinary
Patrick Metze, Hanna Frantz, Fabian Straubmueller, Tobias Speidel, Kilian Stumpf, Meinrad Beer, Wolfgang Rottbauer, Volker Rasche
Summary: The purpose of this study was to adapt the non-uniform self-gating (nuSG) method and compare it to established self-gating approaches for lung imaging. The results showed that nuSG is capable of reconstructing high-quality images for both uniform and non-uniform breathing patterns, and can resolve additional motion or lack of clear motion surrogate.
FRONTIERS IN PHYSICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiyo S. Athertya, Johnny Akers, Sam Sedaghat, Zhao Wei, Dina Moazamian, Sophia Dwek, Mya Thu, Hyungseok Jang
Summary: In this study, the feasibility of quantitative ultrashort echo time (qUTE) magnetic resonance (MR) imaging techniques for detecting and quantifying iron oxide nanoparticle (IONP)-labeled stem cells was investigated. The results showed that qUTE techniques exhibited high linearity in detecting IONP-labeled stem cells, with UTE-QSM performing superior amongst all methods.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Biophysics
Anke Balasch, Patrick Metze, Hao Li, Wolfgang Rottbauer, Alireza Abaei, Volker Rasche
Summary: The study combined 2D ultrashort echo-time (UTE) technique with tiny golden angle (tyGA) ordering to image lung parenchyma in small animals, providing reliable imaging of lung morphology and function. Quantitative parameters such as lung density, T2*, signal-to-noise ratio, fractional ventilation, and perfusion were quantified, and dynamic contrast agent (CA)-enhanced (DCE) qualitative perfusion assessment was conducted. The technique showed good to excellent interobserver reproducibility and excellent intraobserver reproducibility, although interstudy reproducibility was only fair to good.
NMR IN BIOMEDICINE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Amir Masoud Afsahi, Yajun Ma, Hyungseok Jang, Saeed Jerban, Christine B. Chung, Eric Y. Chang, Jiang Du
Summary: This review article summarizes recent technical developments in ultrashort echo time (UTE) magnetic resonance imaging of musculoskeletal (MSK) tissues with short-T2 relaxation times. It discusses contrast mechanisms for high-contrast morphological imaging of short-T2 MSK tissues and introduces quantitative UTE mapping techniques.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Orthopedics
X. Zhang, Y. -J. Ma, Z. Wei, M. Wu, A. Ashir, S. Jerban, S. Li, E. Y. Chang, J. Du
Summary: The study evaluated a 3D UTE-Cones-MT sequence for quantification of macromolecular fraction and MT ratio in menisci of healthy volunteers and patients with different degrees of OA. Results showed decreased MMF and MTR in menisci of OA patients, which negatively correlated with meniscal WORMS scores.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hongda Shao, Jiawei Yang, Yajun Ma, Xiaolian Su, Guangyu Tang, Junjie Jiang, Jiang Du, Jianjun Liu
Summary: The study aimed to investigate the diagnostic efficacy of multi-parametric quantitative UTE-based MRI for evaluating human cartilage degeneration. Among the quantitative MRI biomarkers, UTE-MTR had the strongest correlation with OA grade and collagen organization score. UTE-MTR showed the highest diagnostic efficacy for mild cartilage degeneration, while UTE-AdiabT1 rho and CubeQuant-T2 had lower efficacy.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Review
Biophysics
Alecio F. Lombardi, Monica Guma, Christine B. Chung, Eric Y. Chang, Jiang Du, Ya-Jun Ma
Summary: Osteoarthritis is a common chronic degenerative disease that causes increasing pain and disability worldwide. The osteochondral junction, a dynamic region of the joint, has been relatively overlooked in the imaging and application of osteoarthritis. However, the use of ultrashort echo time (UTE) MR sequences has provided a promising solution for high-resolution imaging and better understanding of the osteochondral junction.
NMR IN BIOMEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaolian Su, Yixuan Zhang, Qiuming Gao, Zonghui Liang, Lidi Wan, Lin Zhang, Guangyu Tang
Summary: This study investigates the feasibility of using quantitative ultrashort echo time magnetic resonance imaging (UTE-MRI) techniques to assess early cartilage degeneration. The results show promising potential for UTE-MRI techniques in diagnosing early cartilage degeneration in patients with knee pain due to osteoarthritis (OA).
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Biophysics
Andreas Boss, Laura Heeb, Divya Vats, Fabian H. L. Starsich, Alice Balfourier, Inge K. Herrmann, Anurag Gupta
Summary: The aim of this study is to detect and quantify the distribution of iron-based nanoparticles in mouse models using ultrashort-echo-time (UTE) sequences. The results showed that UTE sequences can reliably detect the signal decay of nanoparticles in various tissues, and the change in transverse relaxation time is related to the quantity and composition of nanoparticles.
NMR IN BIOMEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kun Hwang, Jang Gyu Cha, Hun Kim, Hyungseok Jang, Dae Joong Kim, Seunghun Lee, Yeo Ju Kim
Summary: This study evaluated the use of 3D UTE and 3D UTE FS imaging techniques to visualize the fascia and epimysium in porcine lower legs. The results showed that 3D UTE and 3D UTE FS can accurately visualize the deep peripheral fascia, but the imaging of the epimysium is insufficient.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
C. Metz, A. M. Weng, J. F. Heidenreich, A. Slawig, T. Benkert, H. Koestler, S. Veldhoen
Summary: This study evaluated the reproducibility of functional lung imaging using non-contrast enhanced multi breath-hold 3D-UTE MRI. The results showed that this method allows for highly reliable ventilation imaging.
MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lidi Wan, Adam C. Searleman, Yajun Ma, Jonathan H. Wong, Judith Williams, Mark E. Murphy, Jiang Du, Eric Y. Chang, Guangyu Tang
Summary: Dehydration of cartilage samples resulted in significant changes in UTE biomarkers, while rehydration with synovial fluid or normal saline had non-significant effects on most of the evaluated UTE biomarkers.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Paul Soullie, Alexia Missoffe, Khalid Ambarki, Jacques Felblinger, Freddy Odille
Summary: This method develops a fast and easy-to-use electrical properties tomography based on a single MR scan, avoiding the need for a B-1 map and transceive phase assumption, and robust against noise. It reconstructs conductivity and permittivity from a new partial differential equation involving RF fields and derivatives, showing advantages over existing methods in various simulation and experimental settings. The method's validity and versatility are demonstrated, promising as a new step forward for clinical applications.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Chemistry, Physical
Ewelina Baran, Artur Birczynski, Przemyslaw Dorozynski, Piotr Kulinowski
Summary: Through the use of 3D 1H UltraShort Echo Time magnetic resonance imaging, the study investigated the spatiotemporal evolution of a hydrophilic polymer matrix tablet hydrated in heavy water. Sodium alginate matrix tablets were used in the experiments, and the images of the matrix during hydration were captured and analyzed using 1H 3D UTE MRI. The findings demonstrated that T2* mapping can effectively serve as a marker for polymer mobilization.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Physics, Multidisciplinary
Patrick Metze, Hanna Frantz, Fabian Straubmueller, Tobias Speidel, Kilian Stumpf, Meinrad Beer, Wolfgang Rottbauer, Volker Rasche
Summary: The purpose of this study was to adapt the non-uniform self-gating (nuSG) method and compare it to established self-gating approaches for lung imaging. The results showed that nuSG is capable of reconstructing high-quality images for both uniform and non-uniform breathing patterns, and can resolve additional motion or lack of clear motion surrogate.
FRONTIERS IN PHYSICS
(2022)
Article
Oncology
Jessica Loeffler, Hendrik Herrmann, Ellen Scheidhauer, Mareike Wirth, Anne Wasserloos, Christoph Solbach, Gerhard Glatting, Ambros J. Beer, Volker Rasche, Gordon Winter
Summary: This study used the chorioallantoic membrane (CAM) model to assess the target-specific binding of radiopharmaceuticals and investigated the feasibility of inhibition studies in the CAM model. The results demonstrated that the CAM model can be used to detect the receptor-specific binding of radiopharmaceuticals. This study provides an alternative to mouse experiments for early evaluation of promising radiopharmaceuticals.
Article
Physics, Multidisciplinary
Tobias Speidel, Patrick Metze, Kilian Stumpf, Thomas Huefken, Volker Rasche
Summary: This manuscript describes a method of three-dimensional k-space sampling that allows reconstruction of arbitrary field of views (FOVs) based on low-coherently sampled k-space. The method exploits the equality between undersampling and reconstruction of a larger FOV. In-vivo images demonstrate the effectiveness of the approach in reconstructing images with a smaller encoded FOV. The method has low-coherent aliasing properties and shows promise for combining with non-linear reconstruction techniques.
FRONTIERS IN PHYSICS
(2022)
Article
Critical Care Medicine
Felix Haussner, Alexander Maitz, Volker Rasche, Andrea Hoffmann, Sonja Braumuller, Ludmila Lupu, Anita Ignatius, Thomas A. Neff, Annette Palmer, Markus Huber-Lang
Summary: Abdominal trauma is a major global issue, and the consequences of blast injuries are often underestimated. In this study using a mouse model, early intestinal damage and impairment of the gut-blood barrier were observed after blunt abdominal trauma. This research provides a sufficient model for further understanding the immunopathophysiological consequences of abdominal trauma and evaluating new therapeutic approaches.
Article
Radiology, Nuclear Medicine & Medical Imaging
Bingjie Yang, Patrick Metze, Anke Balasch, Kilian Stumpf, Meinrad Beer, Wolfgang Rottbauer, Volker Rasche
Summary: This study evaluated the reproducibility of lung function parameters in healthy subjects using 2D UTE and tyGA ordering, showing that functional parameters derived from FB acquisitions are reproducible. BH acquisitions had larger breathing amplitudes and lower reproducibility.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Dagmar Bertsche, Wolfgang Rottbauer, Volker Rasche, Dominik Buckert, Sinisa Markovic, Patrick Metze, Birgid Gonska, Erfei Luo, Tillman Dahme, Ina Vernikouskaya, Leonhard M. Schneider
Summary: This study proposes a vendor-independent approach to integrate planning details into periprocedural image fusion, aiming to enhance the interventional treatment of structural heart disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas Wanek, Severin Mairinger, Marco Raabe, Md Noor A. Alam, Thomas Filip, Johann Stanek, Gordon Winter, Lujuan Xu, Christian Laube, Tanja Weil, Volker Rasche, Claudia Kuntner
Summary: This study evaluated the biokinetics and biodistribution of 68Ga-radiolabelled NDs in a xenograft model. The results showed that the highest accumulation of labeled NDs was in the liver and spleen, while the tumor had a low radioactivity concentration.
NUCLEAR MEDICINE AND BIOLOGY
(2023)
Article
Pediatrics
Britta Huch, Kilian Stumpf, Anna-Katinka Bracher, Volker Rasche, Daniel Vogele, Catharina Schuetz, Ales Janda, Meinrad Beer, Henning Neubauer
Summary: This study investigated the diagnostic accuracy of diffusion-weighted MRI with intravoxel incoherent motion imaging for detecting synovitis in pediatric patients. The results suggest that this method remains a promising alternative to contrast-enhanced imaging, showing restricted synovial diffusion and increased perfusion in patients compared to healthy volunteers.
PEDIATRIC RHEUMATOLOGY
(2022)
Article
Plant Sciences
Cora F. Carmesin, Fabian Port, Samuel Boehringer, Kay-Eberhard Gottschalk, Volker Rasche, Steven Jansen
Summary: This study aims to quantify the stiffness of intervessel pit membranes and found that their material stiffness is lower than previously estimated, and it undergoes an irreversible mechanical aging process with increasing growth rings.
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Oncology
Dagmar Fischer, Georg Fluegen, Paul Garcia, Nassim Ghaffari-Tabrizi-Wizsy, Laura Gribaldo, Ruby Yun-Ju Huang, Volker Rasche, Domenico Ribatti, Xavier Rousset, Marta Texeira Pinto, Jean Viallet, Yan Wang, Regine Schneider-Stock
Summary: The chorioallantoic membrane (CAM) model is a valuable alternative in vivo test system for studying various aspects of cancer. It can be used to investigate angiogenesis, tumor growth, immune escape, metastasis, and drug resistance. The CAM model is easily accessible due to its location and is a simple, fast, and low-cost tool for studying tumor pathology and treatment responses in vivo.
Article
Chemistry, Multidisciplinary
Martin Gierse, Luca Nagel, Michael Keim, Sebastian Lucas, Tobias Speidel, Tobias Lobmeyer, Gordon Winter, Felix Josten, Senay Karaali, Maximilian Fellermann, Jochen Scheuer, Christoph Mueller, Frits van Heijster, Jason Skinner, Jessica Loeffler, Anna Parker, Jonas Handwerker, Alastair Marshall, Alon Salhov, Bilal El-Kassem, Christophoros Vassiliou, John W. Blanchard, Roman Picazo-Frutos, James Eills, Holger Barth, Fedor Jelezko, Volker Rasche, Franz Schilling, Ilai Schwartz, Stephan Knecht
Summary: We propose a versatile method for preparing hyperpolarized [1-13C]fumarate as a contrast agent for preclinical MRI. We compared this method to a state-of-the-art d-DNP system and found similar polarization levels, but significantly lower preparation effort and faster dosing time for the PHIP process. The in vivo usage of hyperpolarized fumarate as a perfusion agent and the metabolic conversion of fumarate to malate in tumor-bearing mice are demonstrated.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Oncology
Colmar Hilbrig, Jessica Loeffler, Gabriel Fischer, Ellen Scheidhauer, Christoph Solbach, Markus Huber-Lang, Ambros J. J. Beer, Volker Rasche, Gordon Winter
Summary: The CAM model shows promise as an alternative to mouse models in terms of the 3Rs principles. However, further evaluation is needed to determine its value in noninvasive assessment of radiolabeled macromolecules using PET and MRI. This study analyzed the biodistribution and tumor accumulation of Zr-89-labeled albumin in both CAM and mouse models, and found no significant differences in albumin influx kinetics between the two models. These findings suggest that the CAM model could be a potential alternative for initial PET studies on the characteristics of EPR-dependent target accumulation of radiolabeled macromolecules.
Article
Engineering, Biomedical
Dagmar Bertsche, Patrick Metze, Leonhard-Moritz Schneider, Ina Vernikouskaya, Volker Rasche
Summary: The purpose of this study is to investigate the potential benefit of motion-compensation in IGS systems. Based on patient data, the accuracy of the IGI system was assessed and it was found that motion synchronization significantly increased the accuracy. The impact of cardiac and respiratory motion on accuracy and precision was also observed.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2023)
Article
Engineering, Biomedical
Dagmar Bertsche, Mona Pfisterer, Tillman Dahme, Leonhard-Moritz Schneider, Patrick Metze, Ina Vernikouskaya, Volker Rasche
Summary: This study proposes an MRI-based training model for percutaneous closure of the left atrial appendage (LAA). Patient-specific silicone models of the LAA were generated using MRI data, allowing for assessment of the influence of the transseptal puncture (TSP) site on the access to patient-specific LAA shapes. The model demonstrated its usability through simulation of venous access and correct handling of the deployment catheter.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2023)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Colmar Hilbrig, Jessica Loeffler, Gabriel Fischer, Hendrik Herrmann, Christoph Solbach, Markus Huber-Lang, Volker Rasche, Ambros Beer, Gordon Winter
JOURNAL OF NUCLEAR MEDICINE
(2022)
