4.2 Article

Post-exertional malaise among people with long COVID compared to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

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Publisher

IOS PRESS
DOI: 10.3233/WOR-220581

Keywords

Post-acute COVID-19 syndrome; long haul COVID; post-viral fatigue syndrome; exertional intolerance; fatigue

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Long COVID is a condition where symptoms persist for months to years after acute COVID-19. People with Long COVID experience post-exertional malaise (PEM), similar to patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). However, there are significant differences in the triggers, symptoms experienced, recovery, and prevention of PEM between Long COVID and ME/CFS.
BACKGROUND: LongCOVID describes a condition with symptoms that linger for months to years following acuteCOVID-19. Many of these Long COVID symptoms are like those experienced by patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). OBJECTIVE: Wewanted to determine if people with LongCOVID experienced post-exertional malaise (PEM), the hallmark symptom of ME/CFS, and if so, how it compared to PEM experienced by patients with ME/CFS. METHODS: A questionnaire that asked about the domains of PEM including triggers, experience, recovery, and prevention was administered to 80 people seeking care for Long COVID at Bateman Horne Center. Their responses were compared to responses about PEM given by 151 patients with ME/CFS using chi-square tests of independence. RESULTS: All but one Long COVID respondent reported having PEM. There were many significant differences in the types of PEM triggers, symptoms experienced during PEM, and ways to recover and prevent PEM between Long COVID and ME/CFS. Similarities between Long COVID and ME/CFS included low and medium physical and cognitive exertion to trigger PEM, symptoms of fatigue, pain, immune reaction, neurologic, orthostatic intolerance, and gastrointestinal symptoms during PEM, rest to recover from PEM, and pacing to prevent PEM. CONCLUSION: People with Long COVID experience PEM. There were significant differences in PEM experienced by people with Long COVID compared to patients with ME/CFS. This may be due to the newness of Long COVID, not knowing what exertional intolerance is or how to manage it.

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