Review
Rehabilitation
Chiara Arienti, Claudio Cordani, Stefano G. Lazzarini, Matteo J. Del Furia, Stefano Negrini, Carlotte Kiekens
Summary: This article aims to summarize the rehabilitation interventions for fatigue, post-exertional malaise, and orthostatic intolerance caused by post-COVID-19 condition based on the Cochrane evidence. The overall quality of the included evidence was low, but it can generate helpful hypotheses for clinical practice and future research.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Behavioral Sciences
Maria Cristine Campos, Tatyana Nery, Ana Carolina Starke, Ana Cristina de Bem Alves, Ana Elisa Speck, Aderbal Aguiar
Summary: This article summarizes various aspects of assessing COVID-19 infection and proposes tools and methods for assessing long-term COVID-19 fatigue.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Immunology
Saurabh Mehandru, Miriam Merad
Summary: This review examines the underlying pathophysiological mechanisms of post-COVID-19 syndromes, including persistent inflammation, induced autoimmunity, and putative viral reservoirs. The disease is called 'long-haul COVID' or 'post-COVID-19 syndrome', and clinical symptoms include fatigue, dyspnea, and neuropsychiatric syndromes.
Article
Medicine, General & Internal
Franziska Legler, Lil Meyer-Arndt, Lukas Moedl, Claudia Kedor, Helma Freitag, Elisa Stein, Uta Hoppmann, Rebekka Rust, Kirsten Wittke, Nadja Siebert, Janina Behrens, Andreas Thiel, Frank Konietschke, Friedemann Paul, Carmen Scheibenbogen, Judith Bellmann-Strobl
Summary: This study examined the long-term health consequences of Post-COVID-19 syndrome (PCS) in patients with moderate to severe fatigue and exertion intolerance. It found that PCS symptoms could persist beyond 20 months after infection and that patients with PCS-ME/CFS had higher and more persistent symptom severity compared to PCS patients. Subclassifying PCS based on the Canadian Consensus Criteria (CCC) can aid in the management and monitoring of PCS-ME/CFS patients.
Article
Health Care Sciences & Services
C. (Linda) M. C. van Campen, Frans C. Visser
Summary: The symptoms and disease characteristics of long-haul COVID patients are similar to those of ME/CFS patients, and orthostatic intolerance plays an important role in COVID infection symptoms. Long-haul COVID is essentially the same disease as ME/CFS.
Article
Medicine, General & Internal
C. (Linda) M. C. van Campen, Peter C. Rowe, Freek W. A. Verheugt, Frans C. Visser
Summary: Muscle pain, fatigue, and concentration problems are common symptoms among individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This study found that orthostatic stress is an important determinant of postexertional malaise (PEM) in ME/CFS patients, as indicated by significantly increased numeric rating scales (NRS) for pain, fatigue, and concentration even at 7 days post head-up tilt testing (HUT).
FRONTIERS IN MEDICINE
(2021)
Review
Health Care Sciences & Services
Krishna Mohan Surapaneni, Manmohan Singhal, Sofia Rani Saggu, Ashruti Bhatt, Priya Shunmathy, Ashish Joshi
Summary: The study reviewed 33 studies on the persistent symptoms of chronic/long COVID-19, finding that fatigue, dyspnea, headache, and depression are among the most frequently reported symptoms. Female gender and prior hospitalization were identified as risk factors for these long-term effects.
Article
Medicine, Research & Experimental
Alexander E. Boruch, Jacob B. Lindheimer, Jacquelyn C. Klein-Adams, Aaron J. Stegner, Glenn R. Wylie, Jacob Ninneman, Thomas Alexander, Nicholas P. Gretzon, Bishoy Samy, Stephanie M. Van Riper, Michael J. Falvo, Dane B. Cook
Summary: The study aimed to understand how cardiorespiratory and perceptual responses to exercise in GWI patients affect PEM, finding that compared to controls, GWI patients had greater ventilatory equivalent for oxygen, peak leg muscle pain, and fatigue during exercise, but these responses did not significantly predict the severity of PEM.
Article
Medicine, General & Internal
Yukichika Yamamoto, Yuki Otsuka, Naruhiko Sunada, Kazuki Tokumasu, Yasuhiro Nakano, Hiroyuki Honda, Yasue Sakurada, Hideharu Hagiya, Yoshihisa Hanayama, Fumio Otsuka
Summary: The pathogenesis and prognosis of post COVID-19 condition are still unclear. A study found a relatively high incidence of late-onset hypogonadism (LOH) in male patients, even young ones, with post COVID-19. Symptoms such as fatigue, anxiety, cough, and hair loss were more frequent in the LOH group than in the non-LOH group.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pathology
Felix Scholkmann, Christian-Albrecht May
Summary: According to the World Health Organization, there have been over 760 million confirmed COVID-19 cases worldwide and more than 13 billion COVID-19 vaccine doses administered as of April 2023. In addition to acute COVID-19, the infection with SARS-CoV-2 can also result in a post-acute COVID-19 syndrome (PACS). The article discusses the side effects of COVID-19 vaccines, proposes new terms (PCVS, ACVS, and PACVS) to refer to these side effects, and emphasizes the importance of distinguishing between acute and post-acute vaccine-related syndromes.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Sarah Schlick, Marianna Lucio, Gerd Wallukat, Alexander Bartsch, Adam Skornia, Jakob Hoffmanns, Charlotte Szewczykowski, Thora Schroeder, Franziska Raith, Lennart Rogge, Felix Heltmann, Michael Moritz, Lorenz Beitlich, Julia Schottenhamml, Martin Herrmann, Thomas Harrer, Marion Ganslmayer, Friedrich E. Kruse, Robert Laemmer, Christian Mardin, Bettina Hohberger
Summary: This study investigated the potential association between self-reported chronic fatigue and retinal microcirculation in patients with Post-COVID-19 syndrome (PCS). The results suggest that retinal microcirculation may serve as an objective biomarker for chronic fatigue in PCS patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Alaa Ghali, Valentin Lacombe, Camille Ravaiau, Estelle Delattre, Maria Ghali, Geoffrey Urbanski, Christian Lavigne
Summary: This study assessed the effectiveness of pacing in managing patients with post-COVID-19 syndrome (PCS). The results showed that patients with high adherence to pacing had better recovery and improvement rates.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Sergej M. Ostojic
Summary: Post-viral fatigue syndrome (PVFS) is a chronic neurological disease with no definite etiological factor(s) or diagnostic test. Research suggests that irregularities in creatine metabolism may be a feature of PVFS, and supplementing creatine and related compounds could potentially improve fatigue symptoms in patients.
Article
Clinical Neurology
Eva K. Hejbol, Thomas Harbo, Jane Agergaard, Line B. Madsen, Thomas H. Pedersen, Lars J. ostergaard, Henning Andersen, Henrik D. Schroder, Hatice Tankisi
Summary: This study explores the histopathological changes in patients with post-COVID-19 fatigue and finds a wide variety of changes in skeletal muscles, including muscle fiber atrophy, mitochondrial changes, inflammation, and capillary injury. These changes may contribute to the fatigue experienced by patients, partly due to reduced energy supply. Even mild acute infections could lead to long-term myopathy.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Medicine, General & Internal
Indre Bileviciute-Ljungar, Jan-Rickard Norrefalk, Kristian Borg
Summary: A significant number of post-COVID-19 syndrome sufferers experience pain, highlighting the urgent need for pain management.
JOURNAL OF CLINICAL MEDICINE
(2022)