Article
Chemistry, Physical
Aynur Alizada, Hakan Arslan
Summary: The compound 1-(4-chloro-benzoyl)-3-(2-trifluoromethyl-phenyl)thiourea was synthesized and its structure was determined using various techniques. The crystal structure analysis revealed important contributions to crystal packing from different interactions. The density functional theory method was employed to further analyze the compound's properties. Docking studies were also conducted to evaluate its inhibitory action against a key protease of COVID-19. Rating: 7/10
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Plant Sciences
Zhikun Yang, Jiahui Xu, Yumeng Bai, Zhao Wang, Liusheng Duan, Weiming Tan
Summary: The study found that compound S8 exhibited excellent promotion effects on plant growth, positively impacting the growth and development of Arabidopsis thaliana and rice. Molecular docking analysis showed that S8 had a tighter binding with the GID1 receptor, and its bioactivity displayed a clear negative association with the docking score values.
JOURNAL OF PLANT GROWTH REGULATION
(2022)
Article
Cell Biology
Xiang-Ke Chen, Joseph Shiu-Kwong Kwan, Raymond Chuen-Chung Chang, Alvin Chun-Hang Ma
Summary: PTU is a known inhibitor of tyrosinase in zebrafish embryos, but it also affects the process of autophagy. Treatment with PTU leads to aberrant autophagosome formation and lysosomal accumulation in various tissues of zebrafish embryos. While autophagy contributes to pigmentation inhibition caused by PTU, it is not essential for this process.
Article
Crystallography
Martin Tsvetkov, Denitsa Elenkova, Maria Milanova
Summary: Light-emitting phosphors doped with Tb(III) and Sm(III) were synthesized and characterized. The doping content was found to affect the unit cell parameters and crystallite size of the phosphors, while the samples showed promising excitation state lifetimes.
Article
Optics
Benfu Qian, Yulu Wang, Qianran Zhao, Tianzheng Duan, Xiuqing Zhou, Haifeng Zou, Yanhua Song, Keyan Zheng, Ye Sheng
Summary: Adjustable multi-color Gd2O2S:Tb3+, Sm3+ phosphors with good luminescence properties and morphology control have been successfully prepared.
JOURNAL OF LUMINESCENCE
(2022)
Article
Chemistry, Physical
Faiz Rasool, Muhammad Khalid, Muhammad Yar, Khurshid Ayub, Muhammad Tariq, Ajaz Hussain, Mehreen Lateef, Muhammad Kashif, Sana Iqbal
Summary: Two new chalcones were synthesized and studied for their interaction with DNA, urease inhibition, antioxidant potential, and drug discovery potential. Computational and experimental methods were used to investigate their properties and interactions, showing promising results for further drug development.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biochemical Research Methods
N. Sudha, R. Surendran, S. Jeyaram
Summary: This paper presents the synthesis and characterization of a novel organic compound QCC using aldol condensation and carboxamide formation method. The nonlinear optical properties of QCC in polar solvents were studied, showing potential applications in photonics and optoelectronics.
JOURNAL OF FLUORESCENCE
(2022)
Article
Spectroscopy
Qi Hu, Si Chen, Fang Chen
Summary: A convenient chemiluminescence method for thiourea determination was proposed based on the thiourea quenching of the chemiluminescence of Tb3+/ prulifloxacin sensitized KMnO4-Na2SO3 system. The method showed linear calibration graphs in a certain concentration range with satisfactory spiked recoveries. Additionally, a possible mechanism of sensitization and quenching was proposed to explain the process.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Multidisciplinary
Carlos D. Diaz-Marin, Lenan Zhang, Zhengmao Lu, Mohammed Alshrah, Jeffrey C. Grossman, Evelyn N. Wang
Summary: A generic framework of sorption kinetics for hygroscopic hydrogels has been developed, with liquid transport due to chemical potential gradient playing a key role in fast kinetics. The high water uptake is attributed to the hydrogel's expansion during liquid transport. Key design parameters governing the kinetics include initial porosity, hydrogel thickness, and shear modulus.
Article
Chemistry, Multidisciplinary
Ahmed M. Mansour, Ola R. Shehab
Summary: The study characterized experimentally and theoretically the metal complexes and evaluated their toxicity against bacteria, finding that the chelation of Ni(II) ion resulted in inactive species.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Environmental Sciences
Joan Serra-Ventura, Miquel Vidal, Anna Rigol
Summary: This study evaluated the sorption of samarium from aqueous solutions using various biochars and carbon-rich materials. The research found that both batch and continuous-flow experiments were effective in determining the maximum sorption capacities of the materials, highlighting potential alternatives to commercial activated charcoals.
Article
Chemistry, Physical
Julia Devterova, Kirill Kirillov, Anton Nikolaev, Michail Sokolov, Victor Shul'gin, Alexey Gusev, Victor Panyushkin, Wolfgang Linert
Summary: In this study, the effect of terbium ions (Tb3+) on the subphases of a complex compound TbL3 center dot bipy was investigated. By varying the concentration of Tb3+, the compression isotherms, infrared, and luminescence spectra were analyzed. The results demonstrate partial dissociation at low concentrations of terbium ions.
Article
Spectroscopy
Srikanth Dasari, Swati Singh, Zafar Abbas, Sri Sivakumar, Ashis K. Patra
Summary: A series of luminescent complexes were synthesized and studied for their potential as cell imaging and photocytotoxic agents, showing promising results in cellular uptake and cytotoxicity studies, particularly in cancer cells. The complexes exhibited significant binding affinity to DNA and serum proteins, as well as efficient energy transfer for luminescent cellular imaging probes. The modular design strategy offers further potential for developing light-responsive luminescent Ln (III) bioprobes for theranostic applications.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Polymer Science
Tsukasa Takagi, Tomoyuki Toda, Masamitsu Miya, Katsuhiko Takenaka
Summary: In this study, a polymer of (Z)-1-phenyl[3]dendralene was obtained through anionic polymerization with predictable molecular weight and narrow molecular-weight distribution; the polymer mainly contained a 1,4 structure (>90%); the polymerizability of 1Z-P3D was different from that of previously reported P3D.
Article
Chemistry, Physical
Kaouther Derraji, Claude Favotto, Jean-Christophe Valmalette, Sylvie Villain, Gilles Nolibe, Abdallah Lyoussi, Frederic Guinneton, Jean-Raymond Gavarri
Summary: A series of polycrystalline cerium samarium tungstates belonging to a solid solution Ce(2-x)Smx(WO4)3 were synthesized and characterized. Structural defects were observed and the emission spectra were mainly attributed to Sm3+ cations.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Soon-Mo Choi, Eun-Joo Shin, Sun-Mi Zo, Kummara-Madhusudana Rao, Yong-Joo Seok, So-Yeon Won, Sung-Soo Han
Summary: This review article outlines the extended applications of polyurethane-based nanocomposites incorporated with conductive polymeric particles, and provides an overview of the chemistry and fabrication of polyurethanes. The research trends of PU-based conducting materials for EMI shielding, sensors, coating, films, and foams are discussed, particularly in the past 10 years. The electrical conductivity of PU is achieved through the addition of metal nanoparticles, graphene, RGO, and MWCNTs, which greatly affect the properties of nanocomposites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Jalababu Ramani, Madhusudhan Alle, Garima Sharma, K. V. N. Suresh Reddy, Yeongmin Park, K. S. V. Krishna Rao, Jin-Chul Kim
Summary: In this study, pH-responsive hydrogels (GNAHs) based on modified natural polymers were formulated and used for controlled release of the anticancer drug Imatinib mesylate (IMS). The GNAH hydrogels demonstrated porous and canal structures with IMS molecules entrapped within the pores, resulting in excellent controlled-release pattern for more than 48 hours. These findings suggest that GNAH hydrogels could be a potential pH-responsive anticancer drug delivery system for other drugs as well.
Article
Environmental Sciences
Meenakshi Singh, Navonil Mal, Reecha Mohapatra, Trisha Bagchi, Sreestha Dinesh Parambath, Murthy Chavali, Kummara Madhusudana Rao, S. Ramanaiah, Abudukeremu Kadier, Gopalakrishnan Kumar, K. Chandrasekhar, Sang-Hyoun Kim
Summary: This article highlights the importance of algae biorefinery as an alternative solution for renewable energy sources and its potential in improving bio-product recovery. Genetic manipulation and improvement in upstream and downstream platforms, along with technoeconomic strategies, are necessary for maximizing metabolites production. Experimental methodologies in algal photobioreactors promote high biomass production enriched in lipid and starch content under limited environmental conditions.
Article
Chemistry, Physical
Kasula Nagaraja, Kummara Madhusudana Rao, K. S. V. Krishna Rao, Sung Soo Han
Summary: In this study, pH and temperature-sensitive tamarind gum-based hydrogels were synthesized and loaded with 5-fluorouracil as a model drug. The hydrogels showed dual responsive nature and exhibited remarkable toxicity and cell cycle ability against cancer cells.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Polymer Science
Soon Mo Choi, Kummara Madhusudana Rao, Sun Mi Zo, Eun Joo Shin, Sung Soo Han
Summary: Bacterial cellulose is a functional material with wide applications in medical, food, textile industries, and is considered a highly versatile green material.
Article
Chemistry, Multidisciplinary
Maduru Suneetha, Kummara Madhusudana Rao, Sung Soo Han
Summary: This study develops multifunctional hydrogel wound dressings with cell/tissue adhesive, hemostasis, self-healing, and antibacterial properties. The hydrogel exhibits good mechanical properties and enhances cell proliferation, attachment, and spreading. It also shows rapid blood coagulation and antibacterial effects against Escherichia coli and Staphylococcus aureus.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Pharmacology & Pharmacy
Kummara Madhusudana Rao, Maduru Suneetha, Dachuru Vinay Kumar, Hyeon Jin Kim, Yong Joo Seok, Sung Soo Han
Summary: This study developed Dox-encapsulated nanogels that can release the drug under dual stimuli conditions, showing potential for effective cancer treatment.
Article
Pharmacology & Pharmacy
Siva Sankar Sana, Ramakrishna Vadde, Raj Kumar, Sai Kumar Arla, Adinarayana Reddy Somala, K. S. V. Krishna Rao, Vijaya Kumar Naidu Boya, Zhang Zhijun, Kunal Mondal, Narsimha Mamidi
Summary: In this study, green and facile synthesis of zinc oxide nanoparticles (ZnO-NPs) from Grewia flavescens was presented. The ZnO-NPs exhibited antibacterial activity and controlled drug release profile under physiological conditions. The structural and optical characteristics of ZnO-NPs were thoroughly investigated and they were found to have a spherical shape with an average size of 20-30 nm. The ZnO-NPs also showed excellent biocompatibility and antimicrobial activity, making them potential candidates for biomedical applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Polymer Science
Kummara Madhusudana Rao, Uluvangada Thammaiah Uthappa, Hyeon Jin Kim, Sung Soo Han
Summary: This study developed hydrogels for tissue adhesion that are biocompatible, antioxidant, and antibacterial. Tannic acid (TA) and fungal-derived carboxymethyl chitosan (FCMCS) were incorporated in a polyacrylamide (PAM) network using free-radical polymerization. The concentration of TA greatly influenced the physicochemical and biological properties of the hydrogels. The hydrogels showed excellent adhesive properties, biocompatibility with skin fibroblast cells, and enhanced antibacterial properties against both Gram-positive and Gram-negative bacteria.
Article
Polymer Science
Kummara Madhusudana Rao, Hyeon Jin Kim, Soyeon Won, Soon Mo Choi, Sung Soo Han
Summary: Cell-cultured meat, made from in vitro cultivation of animal-derived cells, has gained attention as a potential protein source for the future. Porous hydrogels, acting as artificial extracellular matrix, were studied for their effects on the growth and adhesion of bovine satellite muscle cells. The edible gelatin-based hydrogels, supplemented with grape seed extract, showed favorable characteristics and supported the growth of muscle cells, indicating their potential use in cell growth for cultured meat.
Article
Polymer Science
Kummara-Madhusudana Rao, Kummari Subba Venkata Krishna Rao, Ramasubba-Reddy Palem, Uluvangada-Thammaiah Uthappa, Chang-Sik Ha, Sung-Soo Han
Summary: This study investigated the gel properties of naturally-occurring palmyra palm kernel (PPK) and its potential use in delivering chemotherapeutic drugs. PPK hydrogels demonstrated excellent swelling behavior due to the presence of polysaccharide and encapsulated 5-fluorouracil (5-FU) with an efficiency of up to 62%. Characterization techniques revealed that the PPK hydrogel matrix contained dispersed 5-FU molecules, and the release patterns showed gradual release over 12 hours. These findings suggest the potential of PPK hydrogels for treating colon cancer.
Article
Biochemistry & Molecular Biology
Sivagangi Reddy Nagella, Soojeong Choi, Soo-Yong Park, Chang-Sik Ha, Youngmi Jung, Ramesh Kumar Chitumalla, Joonkyung Jang, Ji-Young Yoon, Ildoo Chung
Summary: In this study, chitosan-based nanogels were developed to provide controlled release of anesthetic drugs for effective postoperative pain management. The nanogels showed high encapsulation efficiencies and computational studies were conducted to evaluate the drug-nanoparticle interaction. In vitro release experiments demonstrated sustained and controlled release of the drug by the nanoparticles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Ceramics
Hyeon Jin Kim, Kummara Madhusudana Rao, K. S. V. Krishna Rao, Sung Soo Han
Summary: Bioactive hydrogels with enhanced bone-like apatite formation were developed using a calcium-free phosphate approach. The structure and properties of the hydrogels were validated through analysis techniques. The hydrogels exhibited a porous structure with a fibrous topology, promoting cell growth and adhesion. The phosphate functionality within the hydrogels facilitated rapid biomineralization.
CERAMICS INTERNATIONAL
(2023)
Review
Chemistry, Organic
Kummari Subba Venkata Krishna Rao, Kasula Nagaraja, Boddu Adilakshmi, Jangam Lakshmidevi, Guddety Viswanatha Reddy, Sung Soo Han, Kummara Madhusudana Rao
Summary: This article discusses the recent applications of chitosan-based composite materials as heterogeneous catalysts in various industrial relevant chemical transformations. Chitosan has tunable characteristics and has been proven to be effective in catalyst and functional material synthesis. The composite materials based on chitosan show excellent catalytic performance in organic transformations and can be used to prepare magnetic nanocomposite catalysts with easy separation and high reusability. This article is highly informative and important for the design of further chemical transformations.
CURRENT ORGANIC CHEMISTRY
(2022)