Article
Multidisciplinary Sciences
Cheng Gao, Qingfu Wang, Junyan Li, Cheryl H. T. Kwong, Jianwen Wei, Beibei Xie, Siyu Lu, Simon M. Y. Lee, Ruibing Wang
Summary: This study reports an in vivo strategy to construct cell-based nanomedicine carriers using bacteria-mimetic gold nanoparticles, which are selectively phagocytosed by immune cells and self-assemble into intracellular aggregates. The optimized carriers improve drug delivery and enhance antitumor immunotherapy through photothermal treatment and immune checkpoint blockade.
Review
Pharmacology & Pharmacy
Yulin Chen, Xianmin Wu, Jiadong Li, Yingying Jiang, Ke Xu, Jiacan Su
Summary: Targeted delivery of therapeutics to the bone can improve the treatment of bone metabolism diseases, and nanotechnology offers a more effective approach with reduced side effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Lei Jiang, Sensen Zhou, Xiaoke Zhang, Cheng Li, Shilu Ji, Hui Mao, Xiqun Jiang
Summary: Mitochondria are key targets for photothermal and photodynamic treatment for cancer, but delivery of therapeutics to these organelles remains a challenge. In this study, authors developed a mitochondrial targeted liposomal delivery platform using a dendritic peptide moiety as a mitochondria targeting moiety and demonstrated its targeting and antitumour efficacy in a mouse model of breast cancer.
NATURE COMMUNICATIONS
(2021)
Article
Nanoscience & Nanotechnology
Lesly Carmona-Sarabia, Gabriel Quinones Veelez, Darilys Mojica-Vazquez, Andrea M. Escalera-Joy, Solimar Esteves-Vega, Esther A. Peterson-Peguero, Vilmalii Loopez-Mejiias
Summary: Extended bisphosphonate-based coordination polymers (BPCPs) were synthesized by reacting BPBPA with bioactive metals Ca2+, Zn2+, and Mg2+. These BPCPs demonstrated pH-dependent degradation and had the ability to encapsulate the antineoplastic drug letrozole. The BPCPs showed significantly higher binding affinity to hydroxyapatite and higher cytotoxicity against breast cancer cells compared to commercial BPCPs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Physical
Roger Borges, Agatha Maria Pelosine, Ana Carolina Santos de Souza, Joel Machado Jr, Giselle Zenker Justo, Lionel Fernel Gamarra, Juliana Marchi
Summary: The treatment of bone cancer involves tumor resection, bone reconstruction, and adjuvant treatments. Bioactive glasses have been used as drug carriers for bone regeneration. Different types of drugs can be delivered using techniques such as micro/nanoparticulation or mesoporous bioactive glass systems. Further research is needed on the combination of kinase inhibitors or antibody-conjugated drugs with bioactive glasses.
Review
Chemistry, Multidisciplinary
Beibei Hu, Yongkang Zhang, Guogang Zhang, Zhongqiu Li, Yongshuai Jing, Jun Yao, Shiguo Sun
Summary: This study introduces the importance of bone-targeted drug delivery systems in cancer treatment and summarizes recent research on bone-targeted anti-tumor therapy, providing new ideas. Bisphosphate is the preferred drug delivery carrier for bone targeting, and its molecular structure plays a crucial role in drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Engineering, Biomedical
Yuan Rui, Haleigh B. B. Eppler, Alexis A. A. Yanes, Christopher M. M. Jewell
Summary: During autoimmunity or organ transplant rejection, the immune system attacks host or transplanted tissue, causing inflammation. Recent advances in vaccine-based antigen-specific therapies offer promising opportunities for treating autoimmune diseases and transplant rejection. Precision and combinatorial delivery of antigens, cytokines, small molecule drugs, and immunomodulators can be facilitated by biomaterial technologies.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Cell Biology
Tin Chanh Pham, Migara Kavishka Jayasinghe, Thach Tuan Pham, Yuqi Yang, Likun Wei, Waqas Muhammad Usman, Huan Chen, Marco Pirisinu, Jinhua Gong, Seongkyeol Kim, Boya Peng, Weixi Wang, Charlene Chan, Victor Ma, Nhung T. H. Nguyen, Dennis Kappei, Xuan-Hung Nguyen, William C. Cho, Jiahai Shi, Minh T. N. Le
Summary: The study presents a novel method for covalently conjugating EVs with targeting moieties using protein ligases, enabling specific delivery of therapeutic payloads to target cells without the need for genetic and chemical modifications. This approach shows promise for enhancing drug efficacy in cancer therapy by targeting specific receptors on cancer cells.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Materials Science, Multidisciplinary
Yitong Wang, Hui Chen, Kaili Lin, Ting Ying, Quan Huang, Xiaopan Cai, Jianru Xiao, Qiang Zhang, Yiyun Cheng
Summary: The study demonstrated that polyethylene glycol-conjugated alendronate-functionalized and chloroquine-loaded polydopamine nanoparticles efficiently inhibited tumor growth and osteolysis by breaking the vicious cycle between tumor cell proliferation and bone resorption, highlighting the potential of autophagy inhibition-associated photothermal therapy as a promising strategy for treating malignant bone tumors.
SCIENCE CHINA-MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Baixue Xiao, Yuxuan Liu, Indika Chandrasiri, Emmanuela Adjei-Sowah, Jared Mereness, Ming Yan, Danielle S. W. Benoit
Summary: This study developed a bone-targeted nanoparticle drug delivery system that enhances fracture healing by modulating macrophage polarization. The experimental results showed that the system is predominantly uptaken by fracture-associated macrophages, resulting in increased M2/M1 ratio and expedited fracture healing, accompanied by upregulation of anti-inflammatory genes and downregulation of pro-inflammatory genes.
Review
Chemistry, Multidisciplinary
Supandeep Singh Hallan, Jhaleh Amirian, Agnese Brangule, Dace Bandere
Summary: Bone metastasis is a fatal phase of cancer that lacks an ideal treatment strategy. Lipid-based nano-carriers, such as liposomes and solid lipid nanoparticles, show great potential in improving bone targeting for the treatment of bone metastasis. This review summarizes the development, design, applications, challenges, and future perspectives of lipid nano-transporters, as well as discussing their economic suitability and alternatives.
Article
Biochemistry & Molecular Biology
Yi Zhang, Yiao Wang, Safak Uslu, Sneha Venkatachalapathy, Mohammad Rashidian, Jonas Schaefer, Andreas Pluckthun, Mark D. Distefano
Summary: A novel method for the conjugation of genetically modified proteins with fluorescent dyes or cell-killing agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Faisal Raza, Liu Siyu, Hajra Zafar, Zul Kamal, Bo Zheng, Jing Su, Mingfeng Qiu
Summary: This paper reviews recent advancements in gelatin-based nanomedicine for cancer therapeutics. Gelatin nanoparticles have high therapeutic potency due to their biocompatibility, biodegradability, stability, and surface properties. The paper discusses various methods for preparing gelatin nanomedicine, as well as different cross-linkers and modifications that can be used. It also evaluates drawbacks and challenges, providing important insights for the development of gelatin-based DDS for cancer therapy.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Pharmacology & Pharmacy
Zimo Liu, Xuefei Zhou, Qi Li, Youqing Shen, Tianhua Zhou, Xiangrui Liu
Summary: A biomimetic nanosystem was developed to escape the mononuclear phagocyte system (MPS) and target tumor tissues. The nanoparticles were coated with fibroblast cell membrane expressing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), which reduced macrophage endocytosis and increased tumor cell uptake. Additionally, encapsulated chloroquine (CQ) suppressed macrophage uptake and synergized with TRAIL to induce tumor cell apoptosis.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Oncology
Robert Coleman
Summary: Bone metastases are common in cancer patients, and the use of bone-targeted agents has been evaluated in multiple clinical trials. Adjuvant bisphosphonates have shown benefits in reducing bone metastases and breast cancer deaths in postmenopausal women with breast cancer. Biomarkers, such as the transcription factor MAF, may help predict patient response to bone-targeted treatments.
Review
Chemistry, Multidisciplinary
Pascal Bertsch, Mani Diba, David J. Mooney, Sander C. G. Leeuwenburgh
Summary: Biomaterials that can self-heal and maintain their structural integrity have significant advantages in biomedicine. Self-healing injectable hydrogels, a new type of biomaterial, have emerged in the past decade. These hydrogels can temporarily fluidize and then recover their mechanical properties under shear stress. They can be administered locally and minimally invasively, and have moldable properties for personalized medicine. Additionally, they facilitate tissue regeneration through their viscoelastic and diffusive nature. However, challenges remain in balancing self-healing and injectability with physical stability, establishing consensus on rheological characterization, and translating them into therapeutically effective formulations for specific tissues.
Article
Polymer Science
Alexander Banger, Peter Pasch, Luca-Cesare Blawitzki, Simon Weber, Marius Otten, Cornelia Monzel, Stephan Schmidt, Jens Voskuhl, Laura Hartmann
Summary: This study explores the cell's glycocalyx model by synthesizing amphiphilic glycan-functionalized oligomers and introducing an aggregation-induced luminophore for detection and localization of clustering events in self-assembled structures.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Article
Chemistry, Physical
Hongtao Qu, Yantao Wang, Jiangwei Ju, Ernst R. H. Van Eck, Guanglei Cui, Arno P. M. Kentgens
Summary: We investigated the impact of Al incorporation on the structure and dynamics of Al-doped lithium thiophosphates (Li3-3xAlxPS4) based on beta-Li3PS4. The results showed that Al3+ ions occupied octahedral sites in the structure and the maximum Al incorporation was x=0.06 in Li3-3xAlxPS4. The ionic conductivity of beta-Li3PS4 was significantly enhanced by over three times due to Al incorporation. Further increase of the Al doping level led to the formation of a more complicated material with multiple crystalline and distorted phases, resulting in a high ionic conductivity at room temperature.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Physical
Kostas Fykouras, Jonathan Lahnsteiner, Nico Leupold, Paul Tinnemans, Ralf Moos, Fabian Panzer, Gilles A. A. de Wijs, Menno Bokdam, Helen Grueninger, Arno P. M. Kentgens
Summary: In this study, the reorientational dynamics of MA ions in mixed halide perovskites are investigated using experimental and simulation methods. It is found that the dynamics of MA ions are influenced by the disorder in halide distribution. These findings provide fundamental insights into charge carrier diffusion and lifetime in mixed halide perovskite materials.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Multidisciplinary
Tatiana Soto-Montero, Suzana Kralj, Wiria Soltanpoor, Junia S. Solomon, Jennifer S. Gomez, Kassio P. S. Zanoni, Abhyuday Paliwal, Henk J. Bolink, Christoph Baeumer, Arno P. M. Kentgens, Monica Morales-Masis
Summary: Vapor deposition shows great potential for scalable and industrial processing of perovskite solar cells, offering advantages such as toxicity-free processing, thickness control, and uniform coating. However, the different volatilities of the organic and inorganic components of perovskites currently require multiple thermal sources or two-step deposition. In this study, single-source, single-step pulsed laser deposition is demonstrated for the deposition of tunable MA(1-x)FA(x)PbI(3) thin films. The room temperature formation of cubic alpha-phase MA(1-x)FA(x)PbI(3) films is achieved by controlling laser ablation of a solid target with adjustable ratios of MAI:FAI:PbI2. The target-to-film transfer of the ablated species is confirmed, and proof-of-concept solar cells with 14% efficiency are demonstrated. This research paves the way for future developments in industry-compatible vapor deposition methods for perovskite solar cells.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Michele Denise Illmann, Lea Schaefl, Felicitas Drees, Laura Hartmann, Stephan Schmidt
Summary: This study presents the preparation of glycan-functionalized polyelectrolytes for capturing carbohydrate-binding proteins and bacteria in liquid condensate droplets. The introduction of carbohydrates has a notable effect on the phase separation and the critical salt concentration. The specific mannose-mediated binding functionalization reduces non-specific charge-charge interactions between the protein/bacteria and the droplets.
Article
Chemistry, Physical
Mahdis Hesami, Carolina Hessler, Stephan Schmidt, Peter Schmiedel
Summary: Using perfume oil as a liquid phase, this study investigates the gelling behavior, rheological properties, and microstructure of cyclic dipeptides-based gels. The correlation between hydrogen-bonding Hansen solubility parameter and the plateau storage modulus of the gelled oils is revealed. Stronger hydrogen bonding results in more elastic gels in a specific non-polar liquid phase, reducing the tendency for syneresis. The findings demonstrate the utility of the Hansen parameter approach for designing organogels with tailored material properties for specific applications.
COLLOID AND POLYMER SCIENCE
(2023)
Article
Biochemical Research Methods
Bing Wu, Ruud L. E. G. Aspers, Arno P. M. Kentgens, Evan Wenbo Zhao
Summary: By using high-field operando NMR analysis, researchers gained insights into the working mechanisms of RFBs and improved battery performance. However, the high cost and large footprint of the high-field NMR system limited its implementation. As an alternative, they demonstrated an operando NMR study of an RFB using a low-cost and compact 43 MHz benchtop system, obtaining different results from high-field NMR experiments and providing new insights into RFBs. They concluded that the benchtop NMR system has sufficient capabilities for operando studies of RFBs and could be widely applied in flow electrochemistry research.
JOURNAL OF MAGNETIC RESONANCE
(2023)
Article
Chemistry, Multidisciplinary
Alexander Baer, Ingo Hoffmann, Najet Mahmoudi, Alexandre Poulhazan, Matthew J. Harrington, Georg Mayer, Stephan Schmidt, Emanuel Schneck
Summary: To understand the mechanoresponsive behavior of the bio-adhesive slime, the nanostructural organization of its components was studied using small-angle scattering with neutrons and X-rays. It was found that the majority of slime proteins exist freely in solution, while only less than 10% are contained in nanoglobules. Comparing scattering data of slime re-hydrated with light and heavy water revealed that the majority of lipids are contained in nanoglobules with homogeneous distribution. Vibrating mechanical impact without air did not lead to fiber formation, suggesting that interfacial phenomena and directional shearing are required for fiber formation.
Article
Multidisciplinary Sciences
Yantao Wang, Hongtao Qu, Bowen Liu, Xiaoju Li, Jiangwei Ju, Jiedong Li, Shu Zhang, Jun Ma, Chao Li, Zhiwei Hu, Chung-Kai Chang, Hwo-Shuenn Sheu, Longfei Cui, Feng Jiang, Ernst R. H. van Eck, Arno P. M. Kentgens, Guanglei Cui, Liquan Chen
Summary: By regulating the nucleation energy, crystallites within glass ceramics can self-organize into hetero-nanodomains during the solid-state reaction, resulting in numerous closely spaced grain boundaries with enriched charge carriers, enabling superior Li+-conduction.
NATURE COMMUNICATIONS
(2023)
Article
Polymer Science
Julian Cremer, Bernhard P. Kaltschmidt, Annika Kiel, Jens Eberhard, Stephan Schmidt, Christian Kaltschmidt, Barbara Kaltschmidt, Andreas Huetten, Dario Anselmetti
Summary: The aging-induced surface-covering EBS layers changed the surface morphology, promoting bacterial adhesion and biofilm formation of Pseudomonas aeruginosa. This study provides insight into the time-dependent, polymer-liquid interface aging process of industrial performance polypropylene samples and highlights the detrimental effects of EBS on surface transformation and degradation.
Article
Chemistry, Physical
Shrestha Banerjee, Diana Chaykina, Rens Stigter, Giorgio Colombi, Stephan W. H. Eijt, Bernard Dam, Gilles A. A. de Wijs, Arno P. M. Kentgens
Summary: Rare earth oxyhydrides REOxH(3-2x), with RE = Y, Sc, or Gdand a cationic FCC lattice, show reversible photochromic behavior. The efficiency of the photochromism is determined by the structural details and anion composition. In this study, NMR spectroscopy and DFT calculations are used to investigate the local environments, oxidation states, and dynamics of yttrium, hydrogen, and oxygen in YOxH(3-2x). The results suggest that the samples consist of domains with different hydride contents rather than a homogeneous anion mixing.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Polymer Science
Lorand Bonda, Janita Mueller, Lukas Fischer, Maryna Loewe, Alexej Kedrov, Stephan Schmidt, Laura Hartmann
Summary: The straightforward synthesis of polyamide-derived statistical copolymers with catechol, amine, amide and hydroxy residues via free radical polymerization is presented in this study. The research aims to investigate whether synergistic effects exist in statistical copolymer systems that lack the sequence-defined positioning of functional groups in mussel foot proteins.
Article
Chemistry, Multidisciplinary
Harmke S. Siebe, Andy S. Sardjan, Sarina C. Massmann, Jitte Flapper, Keimpe J. van den Berg, Niek N. H. M. Eisink, Arno P. M. Kentgens, Ben L. Feringa, Akshay Kumar, Wesley R. Browne
Summary: Renewable polysaccharide feedstocks are widely used in bio-based food packaging, coatings, and hydrogels. However, their physical properties often require chemical modification, such as oxidation using periodate, to achieve desired characteristics. In this study, gum arabic was found to undergo oxidation primarily in the rhamnose and arabinose subunits, while galacturonic acids were unaffected. The oxidation process resulted in the formation of substituted dioxanes instead of aldehydes, which has implications for crosslinking strategies in the development of renewable polysaccharide-based materials.
Review
Chemistry, Multidisciplinary
Ulla I. M. Gerling-Driessen, Miriam Hoffmann, Stephan Schmidt, Nicole L. Snyder, Laura Hartmann
Summary: Pathogens, including viruses, bacteria, fungi, and parasites, have a significant impact on our lives. Understanding their mechanisms of adhesion and invasion of host cells has led to the development of glycan-based diagnostics and therapeutics. Glycopolymers, macromolecules with carbohydrates as side chain motifs, have become increasingly important due to their tunable properties. In this review, we discuss the role of glycopolymers in pathogen adhesion and infection, biofilm formation and removal, and drug delivery, as well as their use as diagnostics for pathogen detection and monitoring.
CHEMICAL SOCIETY REVIEWS
(2023)
