Review
Engineering, Biomedical
Manja Kubeil, Yota Suzuki, Maria Antonietta Casulli, Rozy Kamal, Takeshi Hashimoto, Michael Bachmann, Takashi Hayashita, Holger Stephan
Summary: Nanogels have a wide range of applications in the field of biomedicine, particularly in drug delivery, therapeutic applications, tissue engineering, and sensor systems. Cyclodextrin-based nanogels are highly biocompatible and customizable, making them especially important. While most biological investigations are currently carried out in vitro, in vivo applications are becoming more important. Radiolabeled nanogels have potential for imaging and therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Chao-Yi Lu, Derek C. Church, Greg D. Learn, Jonathan K. Pokorski, Horst A. von Recum
Summary: This study investigated the effectiveness of antibiotic-loaded PMMA cement for orthopedic infections. By adding modified CD microparticles, the consistency of drug release and refilling of PMMA cement can be improved. The results showed that incorporating PMMA-CD microparticles can enhance compressive strength, prolong working time, reduce maximum polymerization temperature, and increase drug refilled amount in PMMA cement.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Polymer Science
Aysun Degirmenci, Hazal Ipek, Rana Sanyal, Amitav Sanyal
Summary: Among various nanoscale drug delivery systems, biodegradable polymeric nanogels present a viable platform for targeted cancer therapy. The fabrication of modular redox-responsive nanogel system through host-guest interaction-directed self-assembly of dextran-based polymers is reported here. The nanogels showed enhanced drug release and cytotoxicity against cancer cells, especially in a glutathione-enriched environment.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Chemistry, Applied
Fuat Topuz, Tamer Uyar
Summary: This article summarizes the synthesis and biomedical applications of CD-based nanogels/microgels. By employing structural engineering and functional motifs of CD molecules, nanogels can adapt for the delivery of different types of drugs and significantly enhance the loading capacity and stability of lipophilic drugs.
CARBOHYDRATE POLYMERS
(2022)
Review
Pharmacology & Pharmacy
Karen Escobar, Karla A. Garrido-Miranda, Ruth Pulido, Nelson Naveas, Miguel Manso-Silvan, Jacobo Hernandez-Montelongo
Summary: This review comprehensively covers the chemical properties and synthesis routes of CD/CTR cross-linking, as well as their applications as drug-delivery systems on different substrates. The study found that the CD/CTR biopolymers were nontoxic, environmentally friendly, and inexpensive, making them widely used in coating implants and biomedical materials. The importance of pretreatment methods on substrates and the analysis of release mechanisms, including the Korsmeyer-Peppas mathematical model, were also discussed. The flexibility of CD/CTR in hosting a wide variety of drugs, integrating with diverse implantable materials, and controllable release kinetics provide a range of advantages for future uses.
Review
Pharmacology & Pharmacy
Anthony A. Attama, Petra O. Nnamani, Ozioma B. Onokala, Agatha A. Ugwu, Adaeze L. Onugwu
Summary: Cancer is a significant global health issue and targeted drug delivery using nanogels is a promising strategy for effective cancer therapy. Nanogels possess unique characteristics of hydrogels and nanoparticles, allowing for controlled drug release and reduced side effects. This review summarizes the development of nanogels for targeted drug delivery in cancer therapy over the past decade and discusses ongoing clinical trials and future research prospects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Dmitriy N. Shurpik, Lyaysan Makhmutova, Konstantin S. Usachev, Daut R. Islamov, Olga A. Mostovaya, Anastasia A. Nazarova, Valeriy N. Kizhnyaev, Ivan I. Stoikov
Summary: This study introduces a novel universal stimulus-sensitive nanosized polymer system based on decasubstituted macrocyclic structures-pillar[5]arenes and tetrazole-containing polymers. The system shows significant fluorescence enhancement under acidic conditions, indicating potential applications in the development of new drug delivery systems.
Review
Materials Science, Multidisciplinary
Qiu-Yi Duan, Ya-Xuan Zhu, Hao-Ran Jia, Shi-Hao Wang, Fu-Gen Wu
Summary: This review introduces the history, preparation methods, properties, and applications of nanogels. It first discusses the classification and differences of nanogels from macro-sized hydrogels and other nanoparticles. Then, it focuses on the synthetic methods, properties, and applications of nanogels in drug delivery, imaging, detection, and regenerative medicine. It also raises the current problems and challenges in the field of nanogels, aiming to inspire researchers to develop more functional nanogels and promote their practical applications in various fields.
PROGRESS IN MATERIALS SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Elaheh Dalir Abdolahinia, Ghasem Barati, Zahra Ranjbar-Navazi, Jamileh Kadkhoda, Maryam Islami, Nastaran Hashemzadeh, Solmaz Maleki Dizaj, Simin Sharifi
Summary: Nanogels have emerged as promising drug delivery systems, offering site-specific and time-controlled release of therapeutic agents. They possess key advantages such as high stability, efficient drug loading, and responsiveness to external stimuli, making them highly versatile. Nanogels have shown great potential in various applications including gene delivery, chemotherapy, monitoring, and organ targeting. The use of spheroid tumor models allows for efficient screening of drug-loaded nanogels against cancer cells, reducing costs, time, and ethical concerns before clinical practice.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Rawan Charbaji, Mrityunjoy Kar, Loryn E. Theune, Julian Bergueiro, Anne Eichhorst, Lucila Navarro, Patrick Graff, Friederike Stumpff, Marcelo Calderon, Sarah Hedtrich
Summary: This report describes the synthesis of novel disulfide-containing dendritic polyglycerol (dPG)-based nanogels and their preclinical testing for efficient transmucosal drug delivery. Absorption studies show that these nanogels efficiently overcome mucosal barriers and deliver anti-inflammatory biomacromolecules into epithelial tissues, resulting in local anti-inflammatory effects. The study also highlights the importance of a multifaceted approach for the preclinical testing of mucosal drug-delivery systems.
Review
Polymer Science
Brielle Stawicki, Tyler Schacher, Hyunah Cho
Summary: Chemotherapy and radiation are mainstays in cancer treatment globally, but some therapies have limited specificity and cause harsh side effects in patients. Nanogels, as a unique drug delivery system, show promise in the treatment of brain cancer, despite complications such as handling and chemical stability. Ongoing development of nanogels offers a patient-centered approach for managing brain cancer.
Article
Engineering, Biomedical
Yulong Sun, Yanxin Han, Yannong Dou, Xinqi Gong, Haimang Wang, Xiaoyu Yu, Qiang Wang, Yixin Wang, Yue Dai, Fangfu Ye, Wei Jin, Hongyu Zhang
Summary: This study presents a lubricated nanocontainer for accurate drug delivery to the lesion while avoiding immune system recognition. Through in vitro and in vivo studies, this nanocontainer improves drug bioavailability and shows good biocompatibility.
BIOACTIVE MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Xianbin Ma, Shu-Jin Li, Yuantong Liu, Tian Zhang, Peng Xue, Yuejun Kang, Zhi-Jun Sun, Zhigang Xu
Summary: Nanogels, as a versatile drug delivery system, play a crucial role in cancer immunotherapy, offering advantages such as enhanced drug bioavailability and reduced immune-related adverse events.
CHEMICAL SOCIETY REVIEWS
(2022)
Review
Chemistry, Inorganic & Nuclear
Qiuxiang Wang, Aiwen Zhang, Lu Zhu, Xuewen Yang, Guihua Fang, Bo Tang
Summary: Cyclodextrin (CD), a cyclic oligosaccharide, is a promising pharmaceutical excipient due to its ability to form complexes with small molecules and polymers. Over the past two decades, CD-based ocular drug delivery systems have rapidly developed, offering excellent biocompatibility, safety, and stability. This review discusses recent progress in CD-based ocular drug delivery systems, including drug/CD complexes, CD-based nanocarriers and microcarriers, CD-based hydrogels, and CD-based inserts. Additionally, the methods for ocular safety evaluation and patents and clinical trials for CD-based ocular drug delivery systems are systematically summarized.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Marzia Cirri, Giulia Nerli, Natascia Mennini, Francesca Maestrelli, Paola Mura
Summary: Nanogels that combine the properties of hydrogels and nanocarrier systems are effective drug delivery systems, especially for cutaneous applications. Cyclodextrins can enhance the loading ability of nanogels for poorly soluble drugs and promote sustained drug release. The use of a soluble beta-cyclodextrin/epichlorohydrin polymer (EPI beta CD) without toxic crosslinkers can improve drug delivery efficiency for ibuprofen through enhanced solubility and sustained release.
Article
Nanoscience & Nanotechnology
Akihiro Nishiguchi, Hang Zhang, Sjoeren Schweizerhof, Marie Friederike Schulte, Ahmed Mourran, Martin Moeller
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Biochemistry & Molecular Biology
Akihiro Nishiguchi, Fumiaki Shima, Smriti Singh, Mitsuru Akashi, Martin Moeller
Article
Polymer Science
Jason Dockendorff, Ahmed Mourran, Rustam A. Gumerov, Igor I. Potemkin, Martin Moeller, Mario Gauthier
Article
Polymer Science
Elizaveta Selezneva, Artem Bakirov, Nikita G. Sedush, Aleksandra Bystrova, Sergei N. Chvalun, Dan E. Demco, Martin Moeller
Summary: The study on self-healing polymer materials faces challenges in repairing large-scale defects and requiring the healing process to be generated by the scission itself. The described blend structure includes three types of cross-links, which can homogeneously mix above the melting point and exhibit shape memory effect when heated.
Article
Biotechnology & Applied Microbiology
Ghazi Khalfallah, Rita Gartzen, Martin Moeller, Elisabeth Heine, Rudolf Luetticken
Summary: This study evaluated the potential of certain lactic acid bacteria, classified as probiotics and known for their antimicrobial activity against pathogens, in treating bacterial skin pathogens. The findings suggest that these probiotics could be used in the development of bandages or plasters for the treatment of skin disorders, as they demonstrated antibacterial activity against all tested pathogens.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Biochemistry & Molecular Biology
Stefan Mommer, David Gehlen, Takami Akagi, Mitsuru Akashi, Helmut Keul, Martin Moeller
Summary: Functionalized pullulan with thiolactones allows for cross-linking with diamines and/or amine-containing biological substrates, enhancing versatility for cell proliferation. Studies show that gelatin and GRGDS equally support proliferation of normal human dermal fibroblasts, while GRGDS and GHK significantly improve proliferation of hepatocytes. The strategy of producing biogels using biologically active substrates as cross-linkers is confirmed to be mild and biocompatible.
Article
Chemistry, Physical
Ahmed Mourran, Oliver Jung, Rostislav Vinokur, Martin Moller
Summary: The study demonstrates a system that mimics swimming by microorganisms through simple design principles, using pulsed infrared light irradiation to drive a microswimmer via fast temperature changes. The construction and motion modes of the microswimmer are controlled by plasmonic heating, allowing the ribbons to move at a rate of 6 body length/s with different modes of motion within a confined space.
EUROPEAN PHYSICAL JOURNAL E
(2021)
Article
Multidisciplinary Sciences
Oskar Staufer, Franziska Dietrich, Rahul Rimal, Martin Schroeter, Sebastian Fabritz, Heike Boehm, Smriti Singh, Martin Moeller, Ilia Platzman, Joachim Pius Spatz
Summary: Extracellular vesicles play a crucial role in intercellular communication and cell physiology, but quantitative knowledge on their signaling mechanisms is lacking, hampering their therapeutic applications. By using a synthetic approach, researchers have shown that synthetic EVs have functionalities similar to natural EVs and can be used for therapeutic purposes in wound healing and neovascularization. Transcriptome profiling has enabled a systematic decoding of synergistic effects between individual EV constituents, leading to a better understanding of EV signaling.
Article
Chemistry, Multidisciplinary
Manuela Garay-Sarmiento, Lena Witzdam, Mariia Vorobii, Christian Simons, Niklas Herrmann, Andres de los Santos Pereira, Elisabeth Heine, Islam El-Awaad, Rudolf Luetticken, Felix Jakob, Ulrich Schwaneberg, Cesar Rodriguez-Emmenegger
Summary: The study introduces a hybrid water-soluble macromolecule that prevents bacterial colonization on wound dressings and enhances bactericidal efficiency, offering a novel approach to protect and treat infected wounds.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Polymer Science
Lysann Kassner, Xiaomin Zhu, Karola Schaefer, Zhi Chen, Martin Moeller, Tina Uhlig, Frank Simon, Doreen Dentel, Christoph Tegenkamp, Stefan Spange, Michael Mehring
Summary: Coating textile fibers with nanostructured organic-inorganic hybrid materials can improve their hydrophobicity, solvent resistance, and mechanical properties. By adjusting the ratio of organic and inorganic components, the performance of the coating can be controlled. The coating process can also be combined with other polymerization processes.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Polymer Science
J. Robin Hoehner, Rustam A. Gumerov, Igor I. Potemkin, Cesar Rodriguez-Emmenegger, Nina Yu Kostina, Ahmed Mourran, Jenny Englert, David Schroeter, Lennart Janke, Martin Moeller
Summary: The study focuses on the synthesis of hydrophilic arborescent polymers with high conformational flexibility through grafting-from procedure, showing a strong interfacial activity in liquid-liquid interfaces. The molecules exhibit globular conformation and maintain a high flexibility, contributing to their unique behavior in toluene-in-water suspensions.
Review
Biochemistry & Molecular Biology
[Anonymous]
Summary: Advancements in tissue engineering have led to the understanding of physiological basement membranes. Efforts have been made to synthesize biomimetic membranes for applications in organ models.
Article
Chemistry, Physical
A. A. Stupnikov, A. V. Bakirov, M. A. Shcherbina, U. Beginn, M. Moeller, S. N. Chvalun
Summary: Wedge-shaped dendrons based on benzenesulfonic acid can form different liquid crystal mesophases, such as ordered and disordered columnar hexagonal ones. The size and nature of focal groups as well as the length of aliphatic tails are important factors affecting the phase behavior of these materials. The study found that certain dendrons can form a 2D columnar ordered hexagonal mesophase with three annuli: a central channel, virtually hollow channel, and rigid aromatic part enveloped by an aliphatic matrix. The material shows promise for creating temperature-controlled ion-selective membranes.
MOLECULAR SYSTEMS DESIGN & ENGINEERING
(2023)
Article
Polymer Science
Chunchen Zhang, Dan Eugen Demco, Rahul Rimal, Jens Koehler, Rostislav Vinokur, Smriti Singh, Jan Tenbusch, Martin Moeller
Summary: This study demonstrates the reversible formation of hydrogels through hydrophobic interaction using poly(N-alkyl-N-vinylacetamide)s. The polymers with different lengths of alkyl chains can dissolve in ethanol and form thin films. When immersed in water, they swell and form biocompatible hydrogels. The hydrophobic association varies with the length of the alkyl substituents, with shorter chains leading to flowable hydrogels that segregate from excess water and longer chains yielding hydrogels with mechanical properties similar to permanently cross-linked hydrogels.
Article
Nanoscience & Nanotechnology
Akihiro Nishiguchi, Gent Kapiti, J. Robin Hoehner, Smriti Singh, Martin Moeller
ACS APPLIED BIO MATERIALS
(2020)
