Article
Chemistry, Multidisciplinary
Borja Cirera, Alexander Riss, Pingo Mutombo, Jose Urgel, Jose Santos, Marco Di Giovannantonio, Roland Widmer, Samuel Stolz, Qiang Sun, Max Bommert, Roman Fasel, Pavel Jelinek, Willi Auwarter, Nazario Martin, David Ecija
Summary: The design of organometallic complexes is crucial in modern organic chemistry and catalysis. On-surface synthesis has recently emerged as a disruptive method to design compounds and nanomaterials previously considered impossible. The activation of inner diacetylene moieties of a molecular precursor by copper surface adatoms has led to the formation of unprecedented organocopper metallacycles on Cu(111), paving the way for new avenues in organometallic compound engineering and polyyne chemistry on surfaces.
Correction
Chemistry, Inorganic & Nuclear
Firdaus Rahaman Gayen, Abdul Aziz Ali, Debashree Bora, Saptarshi Roy, Supriya Saha, Lakshi Saikia, Rajib Lochan Goswamee, Biswajit Saha
Summary: This study focuses on the synthesis and characterization of a ferrocene functionalized Schiff base containing Cu(II) complex, and demonstrates its catalytic activity in the azide alkyne cycloaddition reaction at parts-per-million levels.
DALTON TRANSACTIONS
(2021)
Review
Chemistry, Physical
Chang-Qing Qin, Cheng Zhao, Guo-Shu Chen, Yun-Lin Liu
Summary: Catalytic enantioselective azide-alkyne cycloaddition (E-AAC) is an efficient technology for constructing diverse chiral triazoles, with applications in synthetic and medicinal chemistry, biological chemistry, and materials science. Significant developments have been made in copper-, nickel-, iridium-, and rhodium-catalyzed E-AAC reactions in the past six years. This review summarizes these advancements according to different strategies implemented.
Article
Chemistry, Multidisciplinary
Matt Timmers, Wouter Peeters, Niels J. Hauwert, Cristianne J. F. Rijcken, Tina Vermonden, Ingrid Dijkgraaf, Rob M. J. Liskamp
Summary: This article describes the site-specific attachment of the reactive TMTHSI-click handle to the N-terminus of peptides and proteins. The resulting molecular constructs can be used in strain-promoted azide alkyne cycloaddition (SPAAC) for reaction with azide-containing proteins. The article also discusses the N-terminal specific attachment of the reactive TMTHSI-click handle to peptides and proteins, followed by strain-promoted cycloaddition with azide-containing compounds.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Atul Kumar, Navaneet Kumar, Deepak Bhadoria
Summary: The first visible-light promoted and photocatalyst-free three-component reaction protocol has been developed to efficiently synthesize 4-functionalized 1,5-disubstituted 1,2,3-triazoles from terminal alkynes, aryl azides, and arylsulfinic acid sodium salts or arylsulfonyl hydrazides in an aqueous medium at room temperature. This reaction offers high regioselectivity, scalability, and good functional group tolerance among its advantages.
Article
Chemistry, Organic
Carl T. Bormann, Christeena Mathew, Margarida M. Antonio, Aude Trotti, Farzaneh Fadaei-Tirani, Kay Severin
Summary: In this study, the synthesis of a terminal 1-alkynyl triazene is described, and subsequent functionalization expands the structural diversity of this compound class. Furthermore, its applications in the synthesis of di- and triynes, as well as in the preparation of (hetero)aromatic triazenes through metal-catalyzed cyclization reactions, are explored.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Beatriz Lozano-Torres, Juan F. Blandez, Alba Garcia-Fernandez, Felix Sancenon, Ramon Martinez-Manez
Summary: This study describes a new method for senescent cell detection based on lipofuscin labeling using a biorthogonal reaction. The method involves a two-step reaction that forms a clear fluorescence pattern in senescent cells, providing an alternative tool for senescent cell detection.
Article
Chemistry, Multidisciplinary
Samuel Pearce, Juan Perez-Mercader
Summary: By integrating various chemical processes, simplification of PISA process and routes to complexity and adaptation in chemical systems can be achieved.
ACS CENTRAL SCIENCE
(2021)
Article
Chemistry, Organic
Robby Vroemans, Sergio R. Ribone, Joice Thomas, Luc Van Meervelt, Thierry Ollevier, Wim Dehaen
Summary: A new method for preparing novel homochiral atropisomeric sulfanyl- and sulfoxide-substituted naphthyltriazoles is described in this study, providing a new pathway for stable 1,2,3-triazole-based atropisomers. Sixteen sulfanyl-substituted naphthyltriazoles were obtained via triazolization reaction, followed by monooxidation. The absolute configuration of the substituted naphthyltriazoles was determined using X-ray crystallography and confirmed with computational DFT calculations.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Xiai Luo, Yu Zhao, Susu Tao, Zhong-Tao Yang, Hui Luo, Weiguang Yang
Summary: A simple synthesis method for (Z)-1,2-dihydro-2-iminoquinolines has been achieved using copper-catalyzed reaction of 1-(2-aminophenyl)ethan-1-ones, sulfonyl azides, and terminal ynones under mild conditions. The Z-configured products are obtained through a base-free CuAAC/ring-opening process due to hydrogen bonding.
Article
Chemistry, Multidisciplinary
Suguru Yoshida, Yuki Sakata, Yoshihiro Misawa, Takamoto Morita, Tomoko Kuribara, Harumi Ito, Yuka Koike, Isao Kii, Takamitsu Hosoya
Summary: Efficient consecutive formation of 1,2,3-triazoles using multiazide platforms has been achieved in this study. A four-step synthesis of tetrakis(triazoles) was successfully performed from a tetraazide platform molecule, based on the unique clickability of the 1-adamantyl azido group. This method was applied to the convergent synthesis of tetrafunctionalized probes in a modular synthetic manner.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Fei-Fei Wang, Jia-Hui Li, Hai-Yan Liu, Shu-Ping Deng, Ying-Ying Liu, Jian-Fang Ma
Summary: Three distinctive coordination polymers were solvothermally synthesized using a resorcin[4]arene ligand. Among them, compound 1 showed efficient and selective catalytic performance, and could be recycled with preservation of its catalytic capability and structural integrity.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Polymer Science
Han Byul Song, Nancy Sowan, Austin Baranek, Jasmine Sinha, Wayne D. Cook, Christopher N. Bowman
Summary: The present study utilized photoinitiated copper-catalyzed azide-alkyne cycloaddition (CuAAC) polymerization to create structurally diverse glassy polymer networks. By systematically altering the monomer backbone rigidity and the reactive functional group density, networks with varied mechanical properties and strengths were obtained. Incorporating flexible monomers and changing the reactive end groups resulted in improvements in elongation at break and tensile toughness in the polymer networks.
Article
Chemistry, Inorganic & Nuclear
Atousa Khanzadeh, Saeed Ataie, R. Tom Baker
Summary: Two tetranuclear Cu(I) complexes with thiolate- and amido-SNS ligands were characterized, and their reactivities in the copper-catalyzed azide-alkyne cycloaddition reaction were studied. The amido ligand undergoes irreversible N-protonation, while the thiolate complex shows good activity and high yields under base-free conditions in water at 70°C. DFT calculations indicate the proton-shuttle role of thiolate donor in the formation of the initial dicopper σ,π-alkynyl intermediate.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Gargi Chakraborti, Tirtha Mandal, Charles Patriot Roy, Jyotirmayee Dash
Summary: A cascade sequence involving [3+2] cycloaddition, 1,2-acyl migration and hydrolysis produces 2H-1,2,3-triazoles with regioselectivity, using a CuI-prolinamide catalyst system in aqueous media. Prolinamide promotes novel organocatalytic 1,2-acyl migration and hydrolysis of N-2-carboxyalkylated triazoles in the reaction.
CHEMICAL COMMUNICATIONS
(2021)
Article
Thermodynamics
Aline Cisse, Judith Peters, Giuseppe Lazzara, Leonardo Chiappisi
Summary: pyDSC is an open-source Python script designed to analyze raw DSC data, providing corrections for spurious signals and utilizing a robust, physically consistent baseline calculation approach. The program offers significantly improved reproducibility compared to standard proprietary software, making it a valuable tool for large-scale DSC experiments.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2021)
Review
Pharmacology & Pharmacy
Sabina Pozzi, Anna Scomparin, Sahar Israeli Dangoor, Daniel Rodriguez Ajamil, Paula Ofek, Lena Neufeld, Adva Krivitsky, Daniella Vaskovich-Koubi, Ron Kleiner, Pradip Dey, Shani Koshrovski-Michael, Noa Reisman, Ronit Satchi-Fainaro
Summary: Three-dimensional cancer models have been developed to study a wide range of biological applications, including cell signaling pathways, metastatic cascade steps, and personalized medicine, in vitro. By combining different cell types and external stimuli, these models can more accurately mimic the biology and pathophysiology of in vivo tumors.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Chemistry, Multidisciplinary
Amrita Sikder, Saptarshi Chakraborty, Priya Rajdev, Pradip Dey, Suhrit Ghosh
Summary: Bioinspired self-assembly using amphiphiles with hydrophobic supramolecular-structure-directing-units has led to the creation of highly stable nanostructures, which are fundamentally different from traditional amphiphiles. The supramolecular assembly is primarily controlled by the specific molecular-recognition motif of the SSDU, enabling precise regulation of internal order and morphology. Additionally, SSDU-derived pi-amphiphiles have shown promise in producing temperature and redox-responsive supramolecular polymers with efficient functional group display and biological activity.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Materials Science, Multidisciplinary
Guido C. Ritsema van Eck, Leonardo Chiappisi, Sissi de Beer
Summary: This article summarizes the research on high-density, end-tethered polymers, also known as polymer brushes, in liquids and their applications in air. It discusses the fundamental concepts and various applications of brushes in air, and provides an outlook on the future large-scale application of brushes. The article also identifies open questions and issues that need to be addressed.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Matthias Kuhnhammer, Larissa Braun, Michael Ludwig, Olaf Soltwedel, Leonardo Chiappisi, Regine von Klitzing
Summary: The article presents a new model to describe the scattering data from foams. The model takes into account the complex structure of foams and provides information on the thickness distribution of liquid films inside the foam. The results show that the average film thickness decreases and the polydispersity increases with decreasing water content.
JOURNAL OF APPLIED CRYSTALLOGRAPHY
(2022)
Article
Materials Science, Multidisciplinary
Ranajit Barman, Priya Rajdev, Tathagata Mondal, Pradip Dey, Suhrit Ghosh
Summary: This article presents the synthesis of thermoresponsive alternating copolymers based on a segmented polyurethane scaffold. The polymers exhibit a lower critical solution temperature (LCST) and can form hollow capsules capable of sequestering hydrophilic guests. The LCST can be tuned by adjusting the degree of polymerization (DP) or hydrophobic/hydrophilic balance. The polymeric system shows excellent biocompatibility and has potential applications as a delivery vehicle in biomedical fields.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Physical
Leonardo Chiappisi, Ingo Hoffmann, Michael Gradzielski
Summary: Based on the dynamics of the membrane, we hypothesize that the number of layers in polyelectrolyte mediated surfactant multilamellar vesicles depends on membrane undulations. Experimental findings show that the membrane becomes stiffer and the fluctuations of the layers are strongly coupled in time and space when surfactants are complexed with chitosan. This results in a low number of layers in the vesicles.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Polymer Science
Samantha Micciulla, Philipp Gutfreund, Matej Kanduc, Leonardo Chiappisi
Summary: This study investigates the conformational transition of nonionic brushes and semidilute solutions induced by hydrostatic pressure and temperature variations. The pressure and temperature phase behavior is found to be nearly identical in both brushes and semidilute solutions, and can be predicted using simple thermodynamic concepts. Molecular dynamics simulations provide insight into the pressure-responsive behavior of nonionic polymers. These findings have important implications for the design of responsive coatings.
Article
Chemistry, Physical
Cyrielle Garreau, Leonardo Chiappisi, Samantha Micciulla, Isabelle Morfin, Stephane Trombotto, Thierry Delair, Guillaume Sudre
Summary: This study describes a simple method to prepare extremely smooth and stable chitosan coatings, and demonstrates the formation of a grafted chitosan network insoluble in acidic aqueous media and stable for at least 2 days at pH 3.5.
Article
Chemistry, Physical
Larissa dos Santos Silva Araujo, Giuseppe Lazzara, Leonardo Chiappisi
Summary: This study investigates the temperature responsive behavior of inclusion complexes formed by weakly anionic alkyl ethoxy carboxylates and alpha and beta-cyclodextrins. The research shows that the inclusion complexes formed with ionized surfactant soften with increasing temperature and exhibit in-plane crystallization. This study provides insights for designing multi-responsive supramolecular systems based on cyclodextrins.
Review
Nanoscience & Nanotechnology
Suhrit Ghosh, Ranajit Barman, Raju Bej, Pradip Dey
Summary: This paper presents the synthesis and self-assembly of a polymer-prodrug conjugate, as well as its stimuli-responsive intracellular dual drug delivery. The conjugate forms nanocapsule-like structures in water and releases the active drug in a reducing environment. The encapsulation of a second drug in the conjugate enhances its cell killing efficiency. These findings demonstrate the potential application of such a dual drug delivery approach.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Cyrielle Garreau, Leonardo Chiappisi, Samantha Micciulla, Nils Blanc, Isabelle Morfin, Amandine Desorme, Tam Mignot, Stephane Trombotto, Thierry Delair, Guillaume Sudre
Summary: Surface treatment with adhesive polymers is a promising solution for immobilizing and studying bacteria cells. This work demonstrates that a chitosan film with a degree of acetylation (DA) of 35% is suitable for studying bacterial growth and antibiotic testing, with the ability to be reused without affecting the grafted film.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Medicine, Research & Experimental
Yana Epshtein, Rachel Blau, Evgeni Pisarevsky, Shani Koshrovski-Michael, Dikla Ben-Shushan, Sabina Pozzi, Gal Shenbach-Koltin, Lidar Fridrich, Marina Buzhor, Adva Krivitsky, Pradip Dey, Ronit Satchi-Fainaro
Summary: This study designed novel polymeric imaging and therapeutic systems for comprehensive melanoma treatment management. By utilizing advanced imaging tools and therapeutic drugs, it can improve treatment efficacy and prevent tumor metastasis.
Article
Chemistry, Physical
Julien Lamolinairie, Benjamin Dollet, Jean-Luc Bridot, Pierre Bauduin, Olivier Diat, Leonardo Chiappisi
Summary: Liquid foams are complex multi-scale structures that require a combination of different techniques for characterization. Researchers have developed a new device that allows simultaneous time-resolved investigation of foams using small-angle neutron scattering, electrical conductivity, and bubble imaging. This device enables comprehensive characterization of foam and its aging from nanometer to centimeter scale in a single experiment.
Article
Chemistry, Physical
Larissa dos Santos Silva Araujo, Leah Watson, Daouda A. K. Traore, Giuseppe Lazzara, Leonardo Chiappisi
Summary: The inclusion complexes of alkyl ethoxy carboxylates with α-cyclodextrin and β-cyclodextrin were studied. The complexation process was found to be enthalpically driven and independent of pH. The complexes self-assembled into highly-ordered supramolecular aggregates, with different morphologies influenced by the number of ethylene oxides in the surfactants and the cyclodextrin cavity size.
