4.5 Article

Protective effecs of baicalin magnesium on non-alcoholic steatohepatitis rats are based on inhibiting NLRP3/Caspase-1/IL-1β signaling pathway

Journal

BMC COMPLEMENTARY MEDICINE AND THERAPIES
Volume 23, Issue 1, Pages -

Publisher

BMC
DOI: 10.1186/s12906-023-03903-2

Keywords

Baicalin magnesium; Non-alcoholic steatohepatitis; Inflammation; Lipid accumulation; Oxidative stress

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This study aimed to investigate the protective effect of baicalin magnesium on non-alcoholic steatohepatitis (NASH) in rats and its underlying mechanisms. The results showed that baicalin magnesium significantly improved lipid deposition, inflammatory response, oxidative stress, and histopathological impairments induced by a high-fat diet. It exerted a protective effect on NASH rats by inhibiting the NLRP3/caspase-1/interleukin (IL)-1 beta inflammatory pathway. Furthermore, baicalin magnesium was found to be more effective than equimolar baicalin and magnesium sulfate in ameliorating NASH symptoms.
Baicalin magnesium is a water-soluble compound isolated from the aqueous solution by Scutellaria baicalensis Georgi. Preliminary experiments have demonstrated that baicalin magnesium can exert protective effects against acute liver injury in rats induced by carbon tetrachloride or lipopolysaccharide combined with d-galactose by regulating lipid peroxidation and oxidative stress. The aim of this study was to investigate the protective effect of baicalin magnesium on non-alcoholic steatohepatitis (NASH) in rats and to elucidate the underlying mechanisms. NASH was induced through a high-fat diet (HFD) for 8 weeks, and Sprague-Dawley rats were intravenously injected with baicalin magnesium, baicalin, and magnesium sulfate for 2 weeks, respectively. Serum was obtained for biochemical analyses and the determination of oxidative stress indicators. Liver tissues were collected for use in liver index assessment, histopathological examination, inflammatory factor analysis, and protein and gene expression analysis. The results revealed that baicalin magnesium markedly improved HFD-induced lipid deposition, inflammatory response, oxidative stress, and histopathological impairments. And baicalin magnesium may exert a protective effect on NASH rats by inhibiting the NLR family pyrin domain involving the 3 (NLRP3)/caspase-1/interleukin (IL)-1 beta inflammatory pathway. Additionally, the effect of baicalin magnesium was remarkably superior to that of equimolar baicalin and magnesium sulfate in regard to ameliorating NASH symptoms. In conclusion, the findings suggested that baicalin magnesium may represent a potential drug for the treatment of NASH.

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