Article
Cell Biology
Guanjie Li, Tomokazu Ohishi, Mika K. Kaneko, Junko Takei, Takuya Mizuno, Manabu Kawada, Masaki Saito, Hiroyuki Suzuki, Yukinari Kato
Summary: A novel defucosylated mouse-dog chimeric anti-EGFR monoclonal antibody, E134Bf, showed high efficacy in vitro and in vivo against canine cancer cells expressing dEGFR, suggesting its potential as a valuable component of antibody treatment regimens for dogs with cancer.
Article
Biochemistry & Molecular Biology
Stefan Dusterhoft, Selcan Kahveci-Tuerkoez, Justyna Wozniak, Anke Seifert, Petr Kasparek, Henrike Ohm, Shixin Liu, Jana Kopkanova, Juliane Lokau, Christoph Garbers, Christian Preisinger, Radislav Sedlacek, Matthew Freeman, Andreas Ludwig
Summary: This study provides insights into the structure and function of the conserved iRhom homology domain (IRHD) and identifies a key motif within IRHD that affects the transport and stability of the iRhom-ADAM17 complex. Mutation of this motif hinders the secretion pathway and prolongs the half-life of iRhom2 and ADAM17. Additionally, disruption of this motif alters the interaction profile of iRhom2 with proteins involved in intracellular vesicle transport.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Nami Tateyama, Hiroyuki Suzuki, Tomokazu Ohishi, Teizo Asano, Tomohiro Tanaka, Takuya Mizuno, Takeo Yoshikawa, Manabu Kawada, Mika K. Kaneko, Yukinari Kato
Summary: The bispecific antibody E134Bf-H77scFv exhibited antitumor activities against dEGFR/dHER2-positive canine tumors, suggesting its potential as a valuable treatment regimen.
Article
Cell Biology
Qing-Min Liu, Li-Li Liu, Xi-Dong Li, Ping Tian, Hao Xu, Zeng-Lian Li, Li-Kun Wang
Summary: The upregulation of lncRNA TUG1 in LPS-induced hepatocyte inflammation was found to protect against liver damage through regulating the miR-140/TNF pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuan Liang, Jingqi Zhao, Haoyang Zou, Jie Zhang, Tiehua Zhang
Summary: Curcumin and its derivatives from Curcuma longa have significant EGFR targeting activities, with their structure playing a crucial role in their inhibitory activities. They have the potential to be tyrosine kinase inhibitors targeting EGFR.
Article
Oncology
Wendy Bernhard, Kris Barreto, Ayman El-Sayed, John DeCoteau, C. Ronald Geyer
Summary: This study demonstrates the use of a molecule as an imaging agent to determine the recruitment of immune cells to tumors. Non-invasive targeted molecular imaging provides a method to monitor immune response with advantages of whole-body imaging, non-invasiveness, and longitudinal monitoring.
Article
Biochemistry & Molecular Biology
Yun Hee Sim, Yun Jung Um, Jeong-Yang Park, Min-Duk Seo, Sang Gyu Park
Summary: This study developed a novel anti-Nectin-2 antibody and an antibody-drug conjugate (c12G1-DM1) that exhibited potent cytotoxic effects against Nectin-2-positive ovarian cancer cells, suggesting its potential as a therapeutic agent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Tracy R. Daniels-Wells, Pierre V. Candelaria, Emiko Kranz, Jing Wen, Lan Wang, Masakazu Kamata, Juan C. Almagro, Otoniel Martinez-Maza, Manuel L. Penichet
Summary: Individuals infected with HIV have an increased risk of developing certain cancers, including non-Hodgkin lymphoma. This study demonstrates that antibodies targeting the transferrin receptor 1 (TfR1) can prolong survival in mouse models of AIDS-NHL. Targeting TfR1 with these antibodies may be a potential therapy for AIDS-NHL.
Article
Oncology
Najib Ben Khaled, Katharina Hammer, Liangtao Ye, Ahmed Alnatsha, Sebastian A. Widholz, Ignazio Piseddu, Simon Sirtl, Julia Schneider, Stefan Munker, Ujjwal Mukund Mahajan, Juan Jose Montero, Joscha Griger, Julia Mayerle, Florian P. Reiter, Enrico N. De Toni
Summary: Research has identified frequent changes in BRCA genes in pancreatic cancer patients, especially in BRCA2. Pancreatic cancers with alterations in BRCA genes are sensitive to treatment with PARP inhibitors. This study shows that the combination of olaparib and TRAIL can be more effective than olaparib alone in killing pancreatic cancer cells. Furthermore, the combination of olaparib and TRAIL also kills cancer cells without BRCA2 mutations. These findings suggest a potential new combination therapy for pancreatic cancer independent of BRCA2 mutations.
Article
Multidisciplinary Sciences
Zhenfang Du, Benjamin P. Brown, Soyeon Kim, Donna Ferguson, Dean C. Pavlick, Gowtham Jayakumaran, Ryma Benayed, Jean-Nicolas Gallant, Yun-Kai Zhang, Yingjun Yan, Monica Red-Brewer, Siraj M. Ali, Alexa B. Schrock, Ahmet Zehir, Marc Ladanyi, Adam W. Smith, Jens Meiler, Christine M. Lovly
Summary: Understanding oncogenic variants at a mechanistic level helps in the development and optimization of treatment strategies. The study reveals the prevalence of ERBB family KDDs in multiple human cancers, and shows that EGFR-KDD functions through different dimerization modes, with its activity being maximally inhibited by blocking both intra- and inter-molecular dimerization. In conclusion, these findings define a new model of EGFR dimerization and provide important insights for the treatment of EGFR-KDD.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Ryuhei Okada, Aki Furusawa, Daniel W. Vermeer, Fuyuki Inagaki, Hiroaki Wakiyama, Takuya Kato, Tadanobu Nagaya, Peter L. Choyke, William C. Spanos, Clint T. Allen, Hisataka Kobayashi
Summary: The combination of hEGFR and CD25-targeted NIR-PIT shows promising therapeutic efficacy for hEGFR expressing cancers, potentially leading to an enhanced immune response by destroying cancer cells and depleting Treg cells in the tumor microenvironment.
Article
Chemistry, Medicinal
Chih-Hung Guo, Wen-Chin Li, Chia-Lin Peng, Pei-Chung Chen, Shih-Yu Lee, Simon Hsia
Summary: This study found that the combination of selenium/fish oil with gefitinib or erlotinib significantly reduced tumor volume and weight in lung cancer treatment, and also reduced metastasis. Furthermore, the combination treatment modulated multiple signaling pathways and immune checkpoint molecules, reduced angiogenesis, cancer stemness, epithelial to mesenchymal transitions, metastasis, and proliferation, and increased cell cycle arrest and apoptosis.
Article
Biochemistry & Molecular Biology
Joost Neijssen, Rosa M. F. Cardoso, Kristen M. Chevalier, Luus Wiegman, Thomas Valerius, G. Mark Anderson, Sheri L. Moores, Janine Schuurman, Paul W. H. Parren, William R. Strohl, Mark L. Chiu
Summary: This study focused on developing a bispecific antibody targeting EGFR and MET pathways to overcome resistance to targeted therapies in nonsmall cell lung cancer patients. By sequentially screening a panel of BsAbs and selecting the optimal bispecific molecule, amivantamab was generated and demonstrated superior antitumor activity in preclinical models. The unique mode of action of amivantamab may provide benefits to patients with malignancies associated with aberrant EGFR and MET signaling.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Hematology
Tiziana Vaisitti, Francesca Arruga, Nicoletta Vitale, Thanh-Trang Lee, Mira Ko, Amy Chadburn, Esteban Braggio, Arianna Di Napoli, Andrea Iannello, John N. Allan, Langdon L. Miller, Brian J. Lannutti, Richard R. Furman, Katti A. Jessen, Silvia Deaglio
Summary: The Richter syndrome (RS) is a transformation of chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, with limited treatment options and high fatality rates. Targeting the receptor tyrosine kinase-like orphan receptor 1 (ROR1) with the antibody-drug conjugate (ADC) VLS-101 has shown promising results in RS patient-derived xenografts, indicating the therapeutic potential of this approach for hematological cancers. A phase 1 clinical trial of VLS-101 (NCT03833180) is currently ongoing in patients with RS and other hematological malignancies.
Article
Cell Biology
Hui Yao, Jiangang Liu, Chi Zhang, Yunxiang Shao, Xuetao Li, Zhengquan Yu, Yulun Huang
Summary: Our study revealed that apatinib inhibits the malignancy of glioma cells by targeting THBS1, potentially through MYH9. This could provide novel targets for glioma therapy.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Tamara Dzinic, Sonja Hartwig, Stefan Lehr, Norbert A. Dencher
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2016)
Article
Oncology
Meike Hutt, Lisa Marquardt, Oliver Seifert, Martin Siegemund, Ines Mueller, Dagmar Kulms, Klaus Pfizenmaier, Roland E. Kontermann
MOLECULAR CANCER THERAPEUTICS
(2017)
Article
Immunology
Irene Marini, Martin Siegemund, Meike Hutt, Roland E. Kontermann, Klaus Pfizenmaier
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Cell Biology
Tamara Dzinic, Norbert A. Dencher
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Article
Multidisciplinary Sciences
Martin Siegemund, Felix Schneider, Meike Hutt, Oliver Seifert, Ines Mueller, Dagmar Kulms, Klaus Pfizenmaier, Roland E. Kontermann
SCIENTIFIC REPORTS
(2018)
Article
Gastroenterology & Hepatology
Kristin Wahl, Martin Siegemund, Frank Lehner, Florian Vondran, Andreas Nuessler, Florian Laenger, Till Krech, Roland Kontermann, Michael P. Manns, Klaus Schulze-Osthoff, Klaus Pfizenmaier, Heike Bantel
Article
Oncology
Oliver Seifert, Aline Plappert, Sina Fellermeier, Martin Siegemund, Klaus Pfizenmaier, Roland E. Kontermann
MOLECULAR CANCER THERAPEUTICS
(2014)
Article
Multidisciplinary Sciences
Roman Fischer, Olaf Maier, Martin Siegemund, Harald Wajant, Peter Scheurich, Klaus Pfizenmaier
Article
Multidisciplinary Sciences
Yvonne Moeller, Martin Siegemund, Sven Beyes, Ricarda Herr, Daniele Lecis, Domenico Delia, Roland Kontermann, Tilman Brummer, Klaus Pfizenmaier, Monilola A. Olayioye
Article
Cell Biology
M. Siegemund, N. Pollak, O. Seifert, K. Wahl, K. Hanak, A. Vogel, A. K. Nussler, D. Goettsch, S. Muenkel, H. Bantel, R. E. Kontermann, K. Pfizenmaier
CELL DEATH & DISEASE
(2012)
Article
Biochemistry & Molecular Biology
Maja Antunovic, Igor Matic, Biserka Nagy, Katarina Caput Mihalic, Josipa Skelin, Jerko Stambuk, Pavle Josipovic, Tamara Dzinic, Mladen Paradzik, Inga Marijanovic
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2019)
Article
Mathematical & Computational Biology
Greta Del Mistro, Philippe Lucarelli, Ines Mueller, Sebastien De landtsheer, Anna Zinoveva, Meike Hutt, Martin Siegemund, Roland E. Kontermann, Stefan Beissert, Thomas Sauter, Dagmar Kulms
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2018)