Optimizing assembly and production of native bispecific antibodies by codon de-optimization

Advances in recombinant antibody manufacturing

(2016) Renate Kunert et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

High-level Expression and Purification of Active Human FGF-2 in Escherichia coli by Codon and Culture Condition Optimization

(2016) Mohammad Reza Soleyman et al.   Iranian Red Crescent Medical Journal

Codon Optimality Is a Major Determinant of mRNA Stability

(2015) Vladimir Presnyak et al.   CELL

Codon optimization of genes for efficient protein expression in mammalian cells by selection of only preferred human codons

(2015) Satoshi Inouye et al.   PROTEIN EXPRESSION AND PURIFICATION

Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG

(2015) Nicolas Fischer et al.   Nature Communications

Optimization protein productivity of human interleukin-2 through codon usage, gene copy number and intracellular tRNA concentration in CHO cells

(2014) Kua-Chun Ou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Codon Optimization OnLine (COOL): a web-based multi-objective optimization platform for synthetic gene design

(2014) Ju Xin Chin et al.   BIOINFORMATICS

Codon optimization of xylA gene for recombinant glucose isomerase production in Pichia pastoris and fed-batch feeding strategies to fine-tune bioreactor performance

(2014) Özge Ata et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

High-level expression of tamavidin 2 in human cells by codon-usage optimization

(2014) Yoshimitsu Takakura et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Expanding Anfinsen’s Principle: Contributions of Synonymous Codon Selection to Rational Protein Design

(2014) Ian M. Sander et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Optimizing membrane-protein biogenesis through nonoptimal-codon usage

(2014) Alexey S Morgunov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Local slowdown of translation by nonoptimal codons promotes nascent-chain recognition by SRP in vivo

(2014) Sebastian Pechmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Biotechnology and genetic engineering in the new drug development. Part II. Monoclonal antibodies, modern vaccines and gene therapy

(2014) Agnieszka Stryjewska et al.   Pharmacological Reports

Biotechnology and genetic engineering in the new drug development. Part I. DNA technology and recombinant proteins

(2014) Agnieszka Stryjewska et al.   Pharmacological Reports

A critical analysis of codon optimization in human therapeutics

(2014) Vincent P. Mauro et al.   TRENDS IN MOLECULAR MEDICINE

Free light chain content in culture media reflects recombinant monoclonal antibody productivity and quality

(2013) Prachi Bhoskar et al.   BIOTECHNOLOGY PROGRESS

Advances in recombinant protein expression for use in pharmaceutical research

(2013) Rene Assenberg et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Recent advances in mammalian protein production

(2013) Ashok D. Bandaranayake et al.   FEBS LETTERS

Genetic Code-guided Protein Synthesis and Folding inEscherichia coli

(2013) Shaoliang Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GeneOptimizer program-assisted cDNA reengineering enhances sRAGE autologous expression in Chinese hamster ovary cells

(2013) Wen Wei et al.   PROTEIN EXPRESSION AND PURIFICATION

EuGene: maximizing synthetic gene design for heterologous expression

(2012) P. Gaspar et al.   BIOINFORMATICS

Computational codon optimization of synthetic gene for protein expression

(2012) Bevan Chung et al.   BMC Systems Biology

Enhanced production of α-cyclodextrin glycosyltransferase in Escherichia coli by systematic codon usage optimization

(2012) Hua Liu et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Evolutionary conservation of codon optimality reveals hidden signatures of cotranslational folding

(2012) Sebastian Pechmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

How the Sequence of a Gene Can Tune Its Translation

(2010) Kurt Fredrick et al.   CELL

An Evolutionarily Conserved Mechanism for Controlling the Efficiency of Protein Translation

(2010) Tamir Tuller et al.   CELL

A Role for Codon Order in Translation Dynamics

(2010) Gina Cannarozzi et al.   CELL

An Unfolded CH1 Domain Controls the Assembly and Secretion of IgG Antibodies

(2009) Matthias J. Feige et al.   MOLECULAR CELL

Transient ribosomal attenuation coordinates protein synthesis and co-translational folding

(2009) Gong Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Selection on Codon Bias

(2008) Ruth Hershberg et al.   Annual Review of Genetics

On the Optimal Ratio of Heavy to Light Chain Genes for Efficient Recombinant Antibody Production by CHO Cells

(2005) Stefan Schlatter et al.   BIOTECHNOLOGY PROGRESS