DNA immunization combined with scFv phage display identifies antagonistic GCGR specific antibodies and reveals new epitopes on the small extracellular loops

Conformational states of the full-length glucagon receptor

(2015) Linlin Yang et al.   Nature Communications

Four individually druggable MET hotspots mediate HGF-driven tumor progression

(2014) Cristina Basilico et al.   JOURNAL OF CLINICAL INVESTIGATION

Exposure of Epitope Residues on the Outer Face of the Chikungunya Virus Envelope Trimer Determines Antibody Neutralizing Efficacy

(2014) R. H. Fong et al.   JOURNAL OF VIROLOGY

A combination of in vitro techniques for efficient discovery of functional monoclonal antibodies against human CXC chemokine receptor-2 (CXCR2)

(2014) Ronald S Boshuizen et al.   mAbs

Phage display and hybridoma generation of antibodies to human CXCR2 yields antibodies with distinct mechanisms and epitopes

(2014) Christine J Rossant et al.   mAbs

Fully Human Antagonistic Antibodies against CCR4 Potently Inhibit Cell Signaling and Chemotaxis

(2014) Urs B. Hagemann et al.   PLoS One

Structural and Pharmacological Characterization of Novel Potent and Selective Monoclonal Antibody Antagonists of Glucose-dependent Insulinotropic Polypeptide Receptor

(2013) Peter Ravn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor

(2013) Susmith Mukund et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monoclonal anti-β1-adrenergic receptor antibodies activate G protein signaling in the absence of β-arrestin recruitment

(2013) Catherine J Hutchings et al.   mAbs

ARGX-110, a highly potent antibody targeting CD70, eliminates tumors via both enhanced ADCC and immune checkpoint blockade

(2013) Karen Silence et al.   mAbs

Opportunities for functional selectivity in GPCR antibodies

(2012) David R. Webb et al.   BIOCHEMICAL PHARMACOLOGY

Molecular basis for negative regulation of the glucagon receptor

(2012) C. M. Koth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic antibodies directed at G protein-coupled receptors

(2010) Catherine J. Hutchings et al.   mAbs

Mapping of human autoantibody binding sites on the calcium-sensing receptor

(2009) E Helen Kemp et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Abortions in dromedaries (Camelus dromedarius) caused by equine rhinitis A virus

(2008) U. Wernery et al.   JOURNAL OF GENERAL VIROLOGY