Cell therapy for Parkinson’s disease with induced pluripotent stem cells

Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use

(2021) Tae Wan Kim et al.   Cell Stem Cell

Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01

(2021) Jinghua Piao et al.   Cell Stem Cell

Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson’s Disease

(2020) Jeffrey S. Schweitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease

(2020) Daisuke Doi et al.   Nature Communications

iPS cell-based therapy for Parkinson's disease: A Kyoto trial

(2020) Jun Takahashi   Regenerative Therapy

Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility

(2019) Huaigeng Xu et al.   Cell Stem Cell

hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson’s Disease

(2019) Andrew F. Adler et al.   Cell Reports

Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model

(2017) Tetsuhiro Kikuchi et al.   NATURE

HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells

(2017) Germán G Gornalusse et al.   NATURE BIOTECHNOLOGY

MHC matching improves engraftment of iPSC-derived neurons in non-human primates

(2017) Asuka Morizane et al.   Nature Communications

Purification of functional human ES and iPSC-derived midbrain dopaminergic progenitors using LRTM1

(2016) Bumpei Samata et al.   Nature Communications

Revisiting the Mechanisms of CNS Immune Privilege

(2015) Antoine Louveau et al.   TRENDS IN IMMUNOLOGY

An Effective Approach to Prevent Immune Rejection of Human ESC-Derived Allografts

(2014) Zhili Rong et al.   Cell Stem Cell

Isolation of Human Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitors by Cell Sorting for Successful Transplantation

(2014) Daisuke Doi et al.   Stem Cell Reports

Toward eliminating HLA class I expression to generate universal cells from allogeneic donors

(2013) H. Torikai et al.   BLOOD

Long-term Clinical Outcome of Fetal Cell Transplantation for Parkinson Disease

(2013) Zinovia Kefalopoulou et al.   JAMA Neurology

Direct Comparison of Autologous and Allogeneic Transplantation of iPSC-Derived Neural Cells in the Brain of a Nonhuman Primate

(2013) Asuka Morizane et al.   Stem Cell Reports

Serotonergic Neurons Mediate Dyskinesia Side Effects in Parkinson's Patients with Neural Transplants

(2010) M. Politis et al.   Science Translational Medicine

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY