Article
Pharmacology & Pharmacy
Yuka Kawato, Hidehiko Fukahori, Koji Nakamura, Atsuo Kanno, Kaori Kubo, Masaki Hiramitsu, Toshihiro Matsuda, Yuichi Hanada, Takako Furukawa, Yutaka Nakajima, Fumitaka Kinugasa, Tatsuaki Morokata
Summary: The presence of CatS in SLE patients suggests its involvement in the pathogenesis, making it a potential therapeutic target for SLE treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Morgane Humbel, Florence Bellanger, Alice Horisberger, Madeleine Suffiotti, Natalia Fluder, Mariko Makhmutova, Amandine Mathias, Renaud Du Pasquier, Craig Fenwick, Camillo Ribi, Denis Comte
Summary: This study identified an immune signature for systemic lupus erythematosus (SLE) based on the expression of signaling lymphocytic activation molecule family (SLAMF) receptors on peripheral blood mononuclear cells (PBMC). The frequency of SLAMF1+ B cells, SLAMF4+ monocytes, and SLAMF4+ NK showed correlations with disease activity. Consensus clustering analysis also identified two cell clusters, SLESMB and SLEcTFH, which were significantly increased in SLE compared to controls.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Michelle Petri, Steven D. Watts, Richard E. Higgs, Matthew D. Linnik
Summary: The study used combinatorial analysis of four molecular biomarkers to classify SLE patients into subsets, revealing differences in clinical manifestations, medication use, geography, time to severe flare, and SRI-4 response rate.
Article
Immunology
Jessica S. Kleer, Pascal A. Rabatscher, Jessica Weiss, Joel Leonardi, Severin B. Vogt, Andrea Kieninger-Grafitsch, Carlo Chizzolini, Uyen Huynh-Do, Camillo Ribi, Marten Trendelenburg
Summary: The study found that epitope-specific anti-C1q in SLE patients is associated with specific disease manifestations, providing more diagnostic value than conventional anti-C1q.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Hongjiang Liu, Yundong Zou, Chen Chen, Yundi Tang, Jianping Guo
Summary: Systemic lupus erythematosus (SLE) is a common autoimmune disease that affects multiple organs and its pathogenesis is still unclear. Circular RNAs (circRNAs) are a novel class of non-coding RNAs with closed loop structure that may play essential roles in gene expression, cell function, and the development of autoimmune diseases, including SLE. CircRNAs exhibit tissue-specific expression patterns and have implications in immune responses and autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Helena Enocsson, Birgitta Gullstrand, Maija-Leena Eloranta, Jonas Wettero, Dag Leonard, Lars Ronnblom, Anders A. Bengtsson, Christopher Sjowall
Summary: In patients with systemic lupus erythematosus (SLE) during a quiescent phase, IL-6 levels, CRP genotype (rs1205), and type I interferon (IFN) gene signature have an impact on basal CRP levels, with IL-6 positively associated and IGS positivity and CRP genotype (rs1205) AA/GA negatively associated with CRP levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Wenqian Wang, Chenran Yue, Sheng Gao, Shuting Li, Jianan Zhou, Jiaqing Chen, Jiahong Fu, Weijian Sun, Chunyan Hua
Summary: Exosomal miRNAs show potential as biomarkers in SLE/LN patients for renal injury diagnosis. Exosomes are considered optimal delivery vehicles due to their high stability, minimal toxicity, low immunogenicity, and specific target effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medical Laboratory Technology
Jian-Jun Huang, Tong-Jun Mao, Zi-Yu Zhang, Gang Feng
Summary: The study investigates the role of lymphocyte-bound C4d and immunoglobulins in the diagnosis and monitoring of SLE. The levels of C4d and Igs were measured in SLE patients, patients with other inflammatory diseases, and healthy individuals. The results suggest that LB-C4d/Igs could be used as reliable indicators for SLE diagnosis and activity monitoring.
CLINICAL BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Jinyan Guo, Guangying Cui, Wei Huang, Zhaohui Zheng, Tianfang Li, Guanmin Gao, Zhen Huang, Yuwei Zhan, Suying Ding, Shengyun Liu, Zujiang Yu, Zhigang Ren
Summary: This study compared the characteristics of the oral microbiome between patients with systemic lupus erythematosus (SLE) and healthy controls, and developed an SLE classifier based on the oral microbiota. The results showed that SLE patients had increased oral microbial diversity and a different microbial community compared to healthy controls. Specific microbial changes were identified and used to construct a classifier for diagnosing SLE.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Wuquan Li, Xiaoran Guan, Yong Wang, Yan Lv, Yuyong Wu, Min Yu, Yeying Sun
Summary: This study investigated cuproptosis-related molecular clusters in systemic lupus erythematosus (SLE) and constructed a predictive model. The optimal machine learning model was selected based on gene expression and immune features, and a CeRNA network based on 5 core diagnostic markers was established. Drugs targeting core diagnostic markers were identified through molecular docking.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Analytical
Yingzhuo Wang, Feng Guo, Donglin Hao, Yunke Guo, Tingting Xu, Qiuxiang Shen, Youjuan Zhu, Jinfeng Su, Lu Wang, Shijia Liu
Summary: By analyzing metabolite profiles in serum samples using a metab-olomics method, this study identified 14 significant metabolites that distinguish patients with SLE from healthy controls. Potential biomarkers such as arabitol, asparagine, and stearic acid were identified, with altered pathways including aspartate metabolism, glycine and serine metabolism, and purine metabolism.
MICROCHEMICAL JOURNAL
(2021)
Article
Medical Laboratory Technology
Zhicheng Ye, Tao Zhang, Menghua Xu, Jin Xu
Summary: This study evaluated sST2 as a potential biomarker in pediatric systemic lupus erythematosus (SLE) patients, and found that sST2 levels were associated with disease activity and other laboratory test results.
CLINICA CHIMICA ACTA
(2023)
Article
Immunology
Lu Xiao, Feng Zhan, Shudian Lin
Summary: This study identified biomarkers and mechanisms associated with systemic lupus erythematosus (SLE) at a transcriptome level, demonstrating their clinical value in SLE patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Y. Guo, X. Li, R. Li, Y. Li, Z. Wang, H. Liu, S. Cao, Ru Li, Y. Zhao, Q. Wang, X. Sun
Summary: This study investigates the diagnostic potential of serum autoantibodies against different UCH-L1 epitopes in NPSLE. The results show that the autoantibody against amino acid 58 to 69 of UCH-L1 (UCH58-69) has the highest diagnostic power in distinguishing NPSLE patients from SLE patients without neuro-psychiatric symptoms. Moreover, increased serum anti-UCH58-69 levels are associated with disease severity in SLE patients.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Medicine, General & Internal
Lu Xiao, Wei Xiao, Shudian Lin
Summary: This study aimed to identify the key genes related to active renal involvement in patients with systemic lupus erythematosus (SLE). A total of 182 differentially expressed genes (DEGs) were identified, and 12 hub genes were found to be positively associated with SLE Disease Activity Index (SLEDAI). The combination model of these hub genes showed certain diagnostic accuracy in detecting renal involvement with high disease activity in SLE patients.
FRONTIERS IN MEDICINE
(2022)