Article
Gastroenterology & Hepatology
Martin Reike-Kunze, Roman Zenouzi, Johannes Hartel, Till Krech, Soren Weidemann, Martina Sterneck, Christina Weiler-Normann, Ansgar W. Lohse, Christoph Schramm, Marcial Sebode
Summary: Phenprocoumon and metamizole are common causative drugs for DILI in Germany. Among various prognostic scores, a MELD score >= 18 at admission showed the best performance in predicting poor outcome in DILI.
LIVER INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Christian M. M. Lange, Jonel Trebicka, Alexander Gerbes, Ali Canbay, Andreas Geier, Uta Merle, Markus Peck-Radosavljevic, Frank Tacke, Tobias Vogelmann, Sina Theis, Hartmut Heinze, Alexander Zipprich
Summary: Limited data is available on patients with cirrhosis in Germany. This study aimed to estimate the prevalence, comorbidities, mortality, healthcare resource utilization, and costs of these patients, as well as the incidence of decompensation of cirrhosis in Germany. The study found that the prevalence of cirrhosis in 2015 was 250/100,000, with an estimated 201,747 patients in the German population. Among patients with compensated cirrhosis, 16.0% developed decompensation within 3 years. Patients with decompensated cirrhosis had a higher burden of comorbidities and higher costs compared to patients with compensated cirrhosis. The 1-year mortality rate after decompensation was significantly higher than in patients with compensated cirrhosis. Only a small percentage of patients with decompensated cirrhosis received liver transplantation or transjugular intrahepatic portosystemic shunts (TIPS). Overall, patients with cirrhosis in Germany face a high healthcare burden, particularly in the decompensated stage.
LIVER INTERNATIONAL
(2023)
Review
Biotechnology & Applied Microbiology
Kewei Li, Mohammad Tharwat, Ellen L. Larson, Philipp Felgendreff, Seyed M. Hosseiniasl, Anan Abu Rmilah, Khaled Safwat, Jeffrey J. Ross, Scott L. Nyberg
Summary: Bioengineered livers (BELs) are a potential solution to the shortage of liver transplantation donor organs. The decellularization-recellularization approach is commonly used to create transplantable BELs. However, challenges still remain in achieving vascular patency and proper cell seeding.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Wenyi Gu, Louisa Schaaf, Hannah Hortlik, Yasmin Zeleke, Maximilian J. Brol, Andreas A. Schnitzbauer, Wolf O. Bechstein, Stefan Zeuzem, Alexander Queck, Kai-Henrik Peiffer, Michael Tischendorf, Andreas Pascher, Wim Laleman, Michael Praktiknjo, Martin S. Schulz, Frank E. Uschner, Florian Rennebaum, Jonel Trebicka
Summary: This study investigated the outcomes and trends of hospitalized patients evaluated for liver transplantation (LT), transplant, and post-LT in Germany over a period of 14 years. The study found that the waiting list mortality rate increased, in-hospital mortality rate decreased, and post-LT patients had a higher rate of hospitalization for complications.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sara Assadiasl, Nuala Mooney, Mohammad Hossein Nicknam
Summary: Cytokines play crucial roles in autoimmune, allergic, and infectious diseases, as well as allograft rejection. Recent advances in novel anti-cytokine agents and gene therapy for immunomodulatory cytokines have shown significant improvements in managing dysregulated cytokine secretion and overexpression.
Article
Gastroenterology & Hepatology
Branden D. Tarlow, W. Ray Kim, Ajitha Mannalithara, Paul Y. Kwo, C. Andrew Bonham, Allison Kwong
Summary: This study found that MELD 3.0 scores beyond 40 are associated with increasing waitlist mortality without adversely affecting posttransplant outcomes. Uncapping the MELD score for waitlist candidates may lead to greater survival benefits from liver transplantation.
Review
Gastroenterology & Hepatology
Puneeta Tandon, Alberto Zanetto, Salvatore Piano, Julie K. Heimbach, Srinivasan Dasarathy
Summary: Frailty is a decline in functional reserve across multiple physiological systems, with key components being sarcopenia and physical frailty. These conditions are common in liver transplant candidates and have been shown to adversely impact clinical outcomes. The liver frailty index and cross-sectional image analysis of muscle area are used to assess physical frailty and sarcopenia, respectively. Nutritional interventions and physical activity are important management strategies, but there is a need for more large-scale trials. It is also recognized that a multidisciplinary approach is necessary to address the various components of frailty in transplant candidates.
JOURNAL OF HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Sunbin Ling, Guangjiang Jiang, Qingyang Que, Shengjun Xu, Junli Chen, Xiao Xu
Summary: Liver transplantation in China has seen rapid development, with China performing the second-highest number of liver transplants globally each year. Despite the challenges, the quality of liver transplantation continues to improve, and there are promising prospects for its future development in China.
LIVER INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Richard C. Daly, Andrew N. Rosenbaum, Joseph A. Dearani, Alfredo L. Clavell, Naveen L. Pereira, Barry A. Boilson, Robert P. Frantz, Atta Behfar, Shannon M. Dunlay, Richard J. Rodeheffer, John A. Schirger, Timucin Taner, Manish J. Gandhi, Julie K. Heimbach, Charles B. Rosen, Brooks S. Edwards, Sudhir S. Kushwaha
Summary: This study demonstrates the successful transplantation using a heart-after-liver transplantation protocol, which provides profound immunologic protection and prevents adverse immunological outcomes in highly sensitized patients requiring combined heart-liver transplantation. The results show near-elimination of donor specific antibodies and minimal rejection episodes, leading to favorable long-term patient and graft outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Multidisciplinary Sciences
George Clarke, Jingwen Mao, Yiyu Fan, Angus Hann, Amita Gupta, Anisa Nutu, Erwin Buckel, Kayani Kayani, Nicholas Murphy, Mansoor N. Bangash, Anna L. Casey, Isla Wootton, Alexander J. Lawson, Bobby V. M. Dasari, M. Thamara P. R. Perera, Hynek Mergental, Simon C. Afford
Summary: The addition of antioxidant N-acetylcysteine (NAC) in normothermic machine perfusion (NMP) can effectively limit the formation and accumulation of methaemoglobin, prolonging the duration of perfusion.
SCIENTIFIC REPORTS
(2023)
Review
Cell Biology
Sunitha Vimalesvaran, Jessica Nulty, Anil Dhawan
Summary: Liver transplantation is the most effective treatment for pediatric end-stage liver disease, but its wider application is hindered by various limitations. Cellular therapies, such as hepatocytes and mesenchymal stromal cells (MSCs), are emerging as attractive alternatives. This review presents the world experience in hepatocyte and MSC transplantation and explores their potential for future effective applications.
Article
Microbiology
Nicoline Stender Arentoft, Dina Leth Moller, Andreas Delhbaek Knudsen, Ranya Abdulovski, Nikolai Kirkby, Soren Schwartz Sorensen, Allan Rasmussen, Susanne Dam Nielsen
Summary: Influenza has a high incidence and frequent complications in kidney and liver transplant recipients, emphasizing the importance of continuous focus on this vulnerable group.
MICROBIOLOGY SPECTRUM
(2023)
Article
Gastroenterology & Hepatology
Ahmad Anouti, Madhukar S. Patel, Lisa B. VanWagner, William M. Lee, John J. Fung, George Cholankeril, Christine S. Hwang, Arjmand R. Mufti, Shannan Tujios, Thomas Kerr, Nicole E. Rich, Jeremy Louissaint, Dev M. Desai, Parsia A. Vagefi, Steven Hanish, Jigesh Shah, Amit G. Singal, Thomas G. Cotter
Summary: Biliary atresia (BA) is the leading indication for pediatric liver transplantation worldwide, but it is uncommon for older liver transplant recipients. The impact of recent donor allocation changes, organ shortage, and evolving transplantation practices on the BA liver transplant population is unknown. The study found that liver transplant outcomes in BA patients are excellent, and optimal graft outcomes are associated with living-donor liver transplantation (LDLT) and higher transplant center volume.
LIVER INTERNATIONAL
(2023)
Review
Endocrinology & Metabolism
Zhen Zhang, Jianyun Sun, Meng Guo, Xuemin Yuan
Summary: Organ transplantation is an effective treatment for end-stage organ failure, but post transplantation diabetes mellitus (PTDM) is a severe complication that affects the survival of recipients. However, PTDM is often overlooked or poorly managed in its early stage. This article provides an overview of the incidence, pathogenesis, and risk factors for PTDM, aiming to improve the quality of life of recipients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Surgery
Michael Darden, Geoff Parker, Edward Anderson, Joseph F. Buell
Summary: Studies show sex disparities in liver transplantation rates. 19% of the disparity can be explained by differences in size between men and women. Transplantation rates vary between genders increase with the ratio of male-to-female height and weight.