Article
Surgery
Christopher W. Mangieri, Cristian D. Valenzuela, Matthew A. Strode, Richard A. Erali, Perry Shen, Russell Howerton, Clancy J. Clark
Summary: Hepatobiliary malignancies often present at an advanced stage, making surgical resection difficult. Liver-directed therapy (LDT), including Y-90 radio-embolization and transarterial chemoembolization (TACE), is increasingly used to facilitate resectability. However, the safety profile of preoperative LDT is limited.
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
Allison J. Kwong, T. Tara Ghaziani, Francis Yao, Daniel Sze, Ajitha Mannalithara, Neil Mehta
Summary: The utilization of locoregional therapy, especially radioembolization, is increasing among liver transplant candidates in the United States. Patients with greater tumor burden and more compensated liver disease receive more treatments while waiting for transplantation. Bridging therapy is associated with a lower risk of waitlist dropout.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Gun Ha Kim, Jin Hyoung Kim, Heung Kyu Ko, Hee Ho Chu, Seong Ho Kim, Ji Hoon Shin, Dong Il Gwon, Gi-Young Ko, Hyun-Ki Yoon, Ki-Hun Kim, Ju Hyun Shim, Nayoung Kim
Summary: Surgical resection plus intraoperative radiofrequency ablation has shown better survival outcomes in patients with intermediate-stage hepatocellular carcinoma, compared to transarterial chemoembolization. This study suggests that surgical resection plus intraoperative radiofrequency ablation may provide a curative treatment option for selected patients who are only eligible for palliative treatment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yun Xu, Yuqin Zhang, Charlie Zhilin Zheng, Cong Li, Tian'an Guo, Ye Xu
Summary: This study compared the therapeutic efficacy of thermal ablation (TA) and hepatic resection (HR) in patients with synchronous colorectal liver metastases (CRLM) without extrahepatic metastases. The results showed that TA and HR provide comparable five-year overall survival (OS) and disease-free survival (DFS) in these patients, but the TA group had a higher rate of local tumor progression.
EUROPEAN RADIOLOGY
(2022)
Article
Multidisciplinary Sciences
Eva Braunwarth, Peter Schullian, Moritz Kummann, Simon Reider, Daniel Putzer, Florian Primavesi, Stefan Staettner, Dietmar Oefner, Reto Bale
Summary: This study evaluated the efficacy, safety, and overall clinical outcome of local treatment for recurrent intrahepatic cholangiocellular carcinoma after hepatic resection. The results showed that repeated aggressive liver-directed therapy in patients with recurrence had comparable survival rates to patients without recurrence and better survival rates than patients receiving palliative treatment.
Article
Multidisciplinary Sciences
A. Bogdanovic, P. Bulajic, D. Masulovic, N. Bidzic, M. Zivanovic, D. Galun
Summary: The study compared short- and long-term outcomes of patients with huge HCC who underwent potentially curative LR or TACE, finding that LR group had higher overall survival rates both before and after propensity score matching. Total bilirubin and TACE treatment were identified as independent prognostic factors associated with long-term survival.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Zhaonan Li, Kaihao Xu, Xueliang Zhou, Dechao Jiao, Xinwei Han
Summary: This study aims to evaluate the safety and effectiveness of using CBCT-guided TACE and simultaneous MWA to treat small HCCs located in the hepatic dome. The results showed that this combination treatment had a significant impact on the patient's survival rate and treatment outcome.
Article
Surgery
Geoffrey Ledoux, Koceila Amroun, Rami Rhaiem, Audrey Cagniet, Arman Aghaei, Olivier Bouche, Christine Hoeffel, Daniele Sommacale, Tullio Piardi, Reza Kianmanesh
Summary: Exclusive laparoscopic thermo-ablation (TA) is a safe and effective treatment for liver malignancies with or without liver resection. In addition to classical risk factors, tumor location in upper segments of the liver is an independent risk factor for local recurrence (LR) after TA.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Chemistry, Medicinal
Koen G. A. M. Hussaarts, Leni van Doorn, Sander Bins, Dave Sprengers, Peter de Bruijn, Roelof W. F. van Leeuwen, Stijn L. W. Koolen, Teun van Gelder, Ron H. J. Mathijssen
Summary: The study found that sorafenib exposure decreased over time during combined treatment with immunosuppressants, and two patients also experienced declining tacrolimus plasma levels. Patients were unable to increase the sorafenib dose higher than 200 mg b.i.d. without experiencing significant toxicity.
Review
Surgery
Seong Wook Shin, Keun Soo Ahn, Sang Woo Kim, Tae-Seok Kim, Yong Hoon Kim, Koo Jeong Kang
Summary: This study found that liver resection (LR) is more effective than local ablation therapies (such as RFA, MWA, and RFA plus TACE) in treating HCC within the Milan criteria. Specifically, LR has better 5-year recurrence-free survival and lower local recurrence rates compared to local ablation therapies.
Article
Oncology
Matteo Serenari, Enrico Prosperi, Marc-Antoine Allard, Michele Paterno, Nicolas Golse, Andrea Laurenzi, Rene Adam, Matteo Ravaioli, Daniel Cherqui, Matteo Cescon
Summary: This study demonstrates that the time interval between hepatic resection (HR) and secondary liver transplantation (SLT) is a key factor in predicting complications after liver transplantation (LT), without affecting hepatocellular carcinoma (HCC)-related death.
Article
Oncology
Kejie Zheng, Anque Liao, Lunan Yan, Jiayin Yang, Tianfu Wen, Wentao Wang, Bo Li, Hong Wu, Li Jiang
Summary: This study aimed to compare the efficacy of hepatic resection (HR) combined with radiofrequency ablation (RFA) versus HR alone in patients with multifocal hepatocellular carcinomas (HCCs). The study found that for selected patients with moderately advanced multifocal HCCs, HR+RFA may offer similar overall survival (OS) and recurrence-free survival (RFS) as HR alone. However, HR may be more suitable for patients with two tumors, or with all lesions in the same lobe or without microvascular invasion (MVI). In addition, en bloc resection may be recommended for patients with all lesions in the same lobe.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Immunology
Yiwen Qiu, Bin Huang, Xianwei Yang, Tao Wang, Shu Shen, Yi Yang, Wentao Wang
Summary: This study analyzed the benefits and risks of ex vivo liver resection and autotransplantation (ELRA) in end-stage hepatic alveolar echinococcosis (AE). The long-term overall survival of the ELRA group was superior to that of the nonsurgical group, and patients with a predicted 12-month mortality risk >75% would significantly benefit from ELRA.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Oncology
Yang Huang, Liangliang Xu, Min Huang, Li Jiang, Mingqing Xu
Summary: This study compared the long-term outcomes of patients with recurrent and multifocal hepatocellular carcinoma (HCC) meeting the Barcelona Clinic Liver Cancer (BCLC) stage A who underwent repeat hepatectomy (RH) or RH combined with intraoperative radiofrequency ablation (RFA). The results showed no significant difference in overall survival and recurrence-free survival between the two treatment groups. However, for patients whose tumors were located in the same lobe, RH alone was associated with better recurrence-free survival than combination treatment.
Article
Oncology
Xi Xu, Xingyu Pu, Li Jiang, Yang Huang, Lunan Yan, Jiayin Yang, Tianfu Wen, Bo Li, Hong Wu, Wentao Wang
Summary: This study compared outcomes for patients with multifocal HCCs meeting the UCSF criteria treated by LDLT or HR + RFA. LDLT provided significantly better OS and RFS than HR + RFA, but HR + RFA was more convenient, less invasive and less costly. In conclusion, LDLT may offer significantly better long-term results for patients with multifocal HCCs meeting the UCSF criteria, while HR + RFA can still be considered as an acceptable curative therapy or a bridge treatment for future transplantation.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
A. Loglio, M. Iavarone, G. Grossi, M. Vigano, M. G. Rumi, F. Facchetti, G. Lunghi, A. Sangiovanni, M. Colombo, P. Lampertico
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2018)
Article
Gastroenterology & Hepatology
Alessandro Cucchetti, Gennaro D'Amico, Franco Trevisani, Maria Cristina Morelli, Alessandro Vitale, Antonio Daniele Pinna, Matteo Cescon
DIGESTIVE AND LIVER DISEASE
(2018)
Article
Gastroenterology & Hepatology
Eleonora Terzi, Massimo Iavarone, Maurizio Pompili, Letizia Veronese, Giuseppe Cabibbo, Mirella Fraquelli, Laura Riccardi, Ludovico De Bonis, Angelo Sangiovanni, Simona Leoni, Maria Assunta Zocco, Sandro Rossi, Nicola Alessi, Stephanie R. Wilson, Fabio Piscaglia
JOURNAL OF HEPATOLOGY
(2018)
Article
Gastroenterology & Hepatology
Roberta D'Ambrosio, Alessio Aghemo, Maria Grazia Rumi, Elisabetta Degasperi, Angelo Sangiovanni, Marco Maggioni, Mirella Fraquelli, Riccardo Perbellini, William Rosenberg, Pierre Bedossa, Massimo Colombo, Pietro Lampertico
LIVER INTERNATIONAL
(2018)
Article
Gastroenterology & Hepatology
Angelo Sangiovanni, Michela Triolo, Massimo Iavarone, Laura Forzenigo, Antonio Nicolini, Giorgio Rossi, Vincenzo La Mura, Massimo Colombo, Pietro Lampertico
LIVER INTERNATIONAL
(2018)
Review
Gastroenterology & Hepatology
Maria Guarino, Anna Sessa, Valentina Cossiga, Federica Morando, Nicola Caporaso, Filomena Morisco
WORLD JOURNAL OF GASTROENTEROLOGY
(2018)
Article
Gastroenterology & Hepatology
Angelo Sangiovanni, Eleonora Alimenti, Riccardo Gattai, Roberto Filomia, Elisabetta Parente, Luca Valenti, Luca Marzi, Gaia Pellegatta, Guglielmo Borgia, Martina Gambato, Natalia Terreni, Ilaria Serio, Luca Belli, Filippo Oliveri, Sergio Maimone, Matteo Brunacci, Roberta D'Ambrosio, Laura Virginia Forzenigo, Francesco Paolo Russo, Mariagrazia Rumi, Michele Barone, Anna Ludovica Fracanzani, Giovanni Raimondo, Edoardo Giovanni Giannini, Maurizia Rossana Brunetto, Erica Villa, Elia Biganzoli, Massimo Colombo, Pietro Lampertico
JOURNAL OF HEPATOLOGY
(2020)
Article
Oncology
Stefania Mantovani, Stefania Varchetta, Dalila Mele, Matteo Donadon, Guido Torzilli, Cristiana Soldani, Barbara Franceschini, Camillo Porta, Silvia Chiellino, Paolo Pedrazzoli, Roberto Santambrogio, Matteo Barabino, Claudia Cigala, Gaetano Piccolo, Enrico Opocher, Marcello Maestri, Angelo Sangiovanni, Stefano Bernuzzi, Florence Lhospice, Manel Kraiem, Mario Umberto Mondelli, Barbara Oliviero
Article
Gastroenterology & Hepatology
Roberta D'Ambrosio, Elisabetta Degasperi, Maria Paola Anolli, Ilaria Fanetti, Marta Borghi, Roberta Soffredini, Massimo Iavarone, Giulia Tosetti, Riccardo Perbellini, Angelo Sangiovanni, Vana Sypsa, Pietro Lampertico
Summary: This study evaluated the incidence of liver-related and non-liver-related events, as well as mortality, in cirrhotic patients treated with DAAs, finding that patient history significantly influences long-term outcomes. Hepatocellular carcinoma was the most common liver-related complication after viral cure in HCV-related cirrhotic patients, who also faced a significant proportion of non-liver-related events due to improved long-term outcomes.
JOURNAL OF HEPATOLOGY
(2022)
Letter
Gastroenterology & Hepatology
Massimo Iavarone, Barbara Antonelli, Anna Maria Ierardi, Matilde Topa, Angelo Sangiovanni, Andrea Gori, Chiara Oggioni, Giorgio Rossi, Gianpaolo Carrafiello, Pietro Lampertico
LIVER INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Gian Eugenio Tontini, Giovanni Aldinio, Nicoletta Nandi, Alessandro Rimondi, Dario Consonni, Massimo Iavarone, Paolo Cantu, Angelo Sangiovanni, Pietro Lampertico, Maurizio Vecchi
Summary: This study evaluated the clinical needs and outcomes of a gastroenterological ward during the COVID-19 outbreaks in a high incidence scenario. The findings showed a decrease in gastroenterological hospitalization and an increase in age, comorbidities, hospital stays, and mortality. The risk of SARS-CoV-2 infection was also higher, but improved outcomes were observed during the second wave with the implementation of enhanced hospital safety protocols and admission management.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Pierpaolo Biondetti, Lorenzo Saggiante, Anna Maria Ierardi, Massimo Iavarone, Angelo Sangiovanni, Filippo Pesapane, Enrico Maria Fumarola, Pietro Lampertico, Gianpaolo Carrafiello
Summary: Interventional radiology image-guided locoregional therapies for HCC have immunomodulatory effects, with a current interest in combining these therapies with immunotherapy for potential synergistic benefits. Immune activation by locoregional therapies alone may not be sufficient for a systemic antitumor response, leading to interest in combined treatments to improve outcomes.
Article
Gastroenterology & Hepatology
Maria Paola Anolli, Elisabetta Degasperi, Lena Allweiss, Angelo Sangiovanni, Marco Maggioni, Caroline Scholtes, Valerie Oberhardt, Christoph Neumann-Haefelin, Maura Dandri, Fabien Zoulim, Pietro Lampertico
Summary: Bulevirtide has received conditional approval from the EMA for treating chronic hepatitis delta, but the optimal duration of therapy remains unknown. In this study, a patient with compensated cirrhosis and esophageal varices achieved hepatitis delta cure after 3 years of bulevirtide monotherapy. Virological and biochemical responses were maintained during the 72-week off-therapy follow-up, and significant improvements were observed in liver biopsy results.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Filippo Pelizzaro, Franco Trevisani, Vittorio Simeon, Alessandro Vitale, Umberto Cillo, Fabio Piscaglia, Gabriele Missale, Angelo Sangiovanni, Francesco G. Foschi, Giuseppe Cabibbo, Eugenio Caturelli, Maria Di Marco, Francesco Azzaroli, Maurizia R. Brunetto, Giovanni Raimondo, Gianpaolo Vidili, Maria Guarino, Antonio Gasbarrini, Claudia Campani, Gianluca Svegliati-Baroni, Edoardo G. Giannini, Andrea Mega, Alberto Masotto, Gian Ludovico Rapaccini, Donatella Magalotti, Rodolfo Sacco, Gerardo Nardone, Fabio Farinati
Summary: This study evaluated the incidence and predictors of non-transplantable recurrence in patients with single hepatocellular carcinoma (HCC) <= 5 cm treated with liver resection (LR). The results showed that HCC size >= 4 cm and high alpha-fetoprotein (AFP) level at the time of LR were independent predictors of recurrence beyond established criteria. Microvascular invasion and microsatellite lesions were identified as additional independent risk factors for non-transplantable recurrence.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Marco Biolato, Giulia Gallusi, Massimo Iavarone, Giuseppe Cabibbo, Simona Racco, Adriano De Santis, Cristina della Corte, Marcello Maida, Adolfo Francesco Attili, Angelo Sangiovanni, Calogero Camma, Giuseppe La Torre, Antonio Gasbarrini, Antonio Grieco
ANNALS OF HEPATOLOGY
(2018)