Article
Gastroenterology & Hepatology
Julia C. Eichholz, Martha M. Kirstein, Thorsten Book, Heiner Wedemeyer, Torsten Voigtlaender
Summary: The technical success and therapeutic decisions of TJLB are directly linked to the presence of absence of liver cirrhosis, with liver cirrhosis patients having lower rates of treatment initiation or adjustment based on TJLB results.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Haijun Zhang, Zhidong Wang, Xiaoquan Wei, Hao Wu, Lei Li, Wuhua Guo, Ling Li, Ruihang Wang, Chao Yang, Xuehua Yan, Fang Wang, Jun Yan, Xun Li
Summary: This study aimed to investigate whether portal hypertension exists before progressing to cirrhosis in patients with hepatic fibrosis. The correlation between Scheuer stage and HVPG was analyzed in 50 patients, and it was found that HVPG is valuable in evaluating the degree of liver fibrosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Tuan Vu, Hanel Eberly, Amy Zheng, Aidan Hintze, Kathryn L. McGillen, Jeffrey Cruz, Benjamin Shin
Summary: A retrospective study of 128 patients with pre-cirrhotic bridging fibrosis and clinically significant portal hypertension demonstrated that these patients had a higher rate of clinical decompensation compared to patients without portal hypertension.
Article
Oncology
Yunhai Yao, Sanjaya K. Satapathy, Eduardo De Souza Martins Fernandes, Odin Ramirez-Fernandez, Alessandro Vitale, Zutao Chen
Summary: This study investigated the incidence of liver failure after Transjugular intrahepatic portal shunt (TIPS) treatment for esophagogastric variceal bleeding, and found that hepatic venous pressure gradient (HVPG) is an independent risk factor. These results can serve as indicators for predicting potential adverse events in patients with cirrhosis after surgery.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Xi-Xuan Wang, Xiao-Chun Yin, Li-Hong Gu, Hui-Wen Guo, Yang Cheng, Yan Liu, Jiang-Qiang Xiao, Yi Wang, Wei Zhang, Xiao-Ping Zou, Lei Wang, Ming Zhang, Yu-Zheng Zhu-Ge, Feng Zhang
Summary: This study evaluated whether TIPS placement improves survival in patients with HVPG greater than or equal to 16 mmHg. The results showed that TIPS placement can effectively improve transplant-free survival in patients with HVPG greater than 16 mmHg, while the survival rates were similar in patients with HVPG less than 16 mmHg. Therefore, TIPS placement is beneficial for patients with HVPG greater than 16 mmHg.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Pediatrics
Prabir Maji, Rohan Malik, K. S. Madhusudhan, Sanjay Sharma
Summary: The study evaluated the safety and efficacy of Transjugular liver biopsy (TJLB) in pediatric patients, showing that TJLB is a safe and useful procedure in children, providing important diagnostic and management information in addition to confirming initial diagnoses.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Medicine, General & Internal
Makoto Iijima, Takahiro Arisaka, Akira Yamamiya, Keiichi Tominaga, Kazunori Nagashima, Akira Kanamori, Satoshi Masuyama, Yuichi Majima, Kenichi Goda, Kazuyuki Ishida, Atsushi Irisawa
Summary: The study found that TJLB is highly useful and safe in patients who are not suitable for PLB, with a high procedural success rate, clinical response rate, and tissue sampling rate, and no serious adverse events were observed in either group.
Article
Medicine, General & Internal
Thomas Geyer, Dirk-Andre Clevert, Sonja Schwarz, Paul Reidler, Sebastian Gassenmaier, Thomas Knoeel, Johannes Ruebenthaler, Vincent Schwarze, Marco Armbruster
Summary: CEUS shows high diagnostic performance in characterizing suspicious liver lesions, with a high sensitivity and true positive rate compared to histopathological results. It is a safe imaging modality for evaluating both benign and malignant liver lesions.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yifan Lv, Qingkun Song, Zhendong Yue, Hongwei Zhao, Lei Wang, Zhenhua Fan, Yifan Wu, Mingming Meng, Ke Zhang, Li Jiang, Huiguo Ding, Yuening Zhang, Fuquan Liu
Summary: This study investigated the correlation between hepatic venous pressure gradient (HVPG) and portal venous pressure gradient (PPG) in hepatitis B cirrhosis patients. The development of collateral channels in the liver veins was found to significantly affect the correlation between HVPG and PPG.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Adi Price, Adam Schwertner, David Tran, Maureen Kohi, K. Pallav Kolli, Andrew Taylor, Nicholas Fidelman
Summary: The study compared the technical successes and complications of TLBs for liver transplant recipients with bicaval and piggyback hepatic vein anastomoses, finding that there were no significant differences between the two groups in terms of procedural success and major complications. While patients with piggyback anastomoses were more likely to encounter difficulties with catheterization or advancing the biopsy cannula, this was a rare occurrence.
Article
Radiology, Nuclear Medicine & Medical Imaging
Nicole E. Curci, Benjamin L. Triche, E. Jason Abel, Gauri Bhutani, Kimberly A. Maciolek, Leo D. Dreyfuss, Glenn O. Allen, Elaine M. Caoili, Matthew S. Davenport, Shane A. Wells
Summary: Administering intravenous iodinated contrast during ablation of cT1a RCC has no effect on eGFR.
EUROPEAN RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Alejandro A. Borquez, Jose Silva-Sepulveda, Jesse W. Lee, Vera Vavinskaya, Irine Vodkin, Hannah El-Sabrout, Richard Towbin, James C. Perry, John W. Moore, Howaida G. El-Said
Summary: TJLB is an alternative method for obtaining critical FALD surveillance data with lower complication rates than traditional techniques. Vascular anomalies in Fontan physiology appear common and warrant pre-biopsy assessment. There is a significant correlation between biopsy score, time from Fontan, mean Fontan pressure, and cardiac index.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Bikrant Bihari Lal, Vikrant Sood, Archana Rastogi, Amar Mukund, Rajeev Khanna, Manoj Kumar Sharma, Seema Alam
Summary: The study evaluated the indications, feasibility, complications, and clinical implications of transjugular liver biopsy in children. The results showed that it is well tolerated, feasible, and helpful in making a diagnosis for about 64% of children, allowing timely medical and/or surgical intervention. Autoimmune hepatitis, drug-induced liver injury, and non-cirrhotic portal fibrosis are the most common diagnoses made.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hector Ferral, Claus J. Fimmel, Amnon Sonnenberg, Marc J. Alonzo, Thomas M. Aquisto
Summary: This study evaluated the correlation between hepatic vein pressure measurements and histologic findings, finding a significant association between hepatic venous pressure gradients and cirrhosis. HVPG and PSG showed high sensitivity and specificity for predicting cirrhosis at a cutoff point of 9mmHg, with no statistical difference between the two measurements.
JOURNAL OF CLINICAL IMAGING SCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hananiel Setiawan, Chaofan Chen, Ehsan Abadi, Wanyi Fu, Daniele Marin, Francesco Ria, Ehsan Samei
Summary: A patient-informed time series model integrating clinical data and pharmacokinetics models can predict liver contrast enhancement, showing potential to improve consistency in contrast-enhanced liver imaging.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Dermatology
Noemie Abisror, Arsene Mekinian, Agnes Dechartres, Matthieu Groh, Alice Berezne, Nicolas Noel, Chafika Morati, Julien Haroche, Mathilde Hunault-Berger, Christian Agard, Felix Ackermann, Loik Geffray, Pierre-Yves Jeandel, Sebastien Trouillier, Thomas Quemeneur, Jean-Francois Dufour, Isabelle Lamaury, Francois Lhote, Guillaume Lefevre, Olivier Fain, Jean Emmanuel Kahn
Summary: EAE is a rare disorder characterized by recurrent episodes of angioedema, hypereosinophilia, and elevated serum IgM level. A multicenter study in France revealed the heterogeneity of clinical manifestations and therapeutic management of EAE patients.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Gastroenterology & Hepatology
M. Leo, A. Galante, A. Pagnamenta, L. Ruinelli, F. R. Ponziani, A. Gasbarrini, A. De Gottardi
Summary: This observational study evaluates the prevalence of transaminases elevation in hospitalized patients affected by COVID-19 and investigates the presence of factors associated with hepatocellular injury and with mortality. It found that transaminases elevation was more common in younger patients and that drug treatment and alkaline phosphatase peak were associated with abnormal transaminases and mortality.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Gastroenterology & Hepatology
Roberto de Franchis, Jaime Bosch, Guadalupe Garcia-Tsao, Thomas Reiberger, Cristina Ripoll
Summary: The Baveno VII workshop focused on personalized care for portal hypertension in patients with compensated cirrhosis or cACLD, discussing various aspects including diagnosis, treatment, and prevention measures in 9 main topics, resulting in a series of consensus recommendations.
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Niels Kristian Aagaard, Massimo Malago, Andrea De Gottardi, Michael Thomas, Gerd Sauter, Cornelius Engelmann, David Aranovich, Michal Cohen, Thierry Thevenot, Thomas Ehmann, Jeroen Capel, Paolo Angeli, Rajiv Jalan, Guido Stirnimann
Summary: The study aimed to improve outcomes for alfapump(R) implantation and patient management by developing consensus recommendations. Through two meetings, 23 consensus recommendations were developed, covering areas such as pre-implantation procedure, surgical implant procedure, immediate post-implant care, and long-term management. These consensus statements serve as a valuable reference resource for physicians managing patients and considering management strategies for refractory ascites.
BMC GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Maxence Emmanuel Reynard, Jean-Francois Dufour
Summary: This study investigates the actual management of patients scheduled for an elective percutaneous biopsy and taking low dose aspirin. Despite the lack of clear guidelines or evidence, 75% of physicians in hepatology choose to stop low dose aspirin before the procedure.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Letter
Gastroenterology & Hepatology
Nahum Mendez-Sanchez, Elisabetta Bugianesi, Robert G. Gish, Frank Lammert, Herbert Tilg, Mindie H. Nguyen, Shiv K. Sarin, Nuria Fabrellas, Shira Zelber-Sagi, Jian-Gao Fan, Gamal Shiha, Giovanni Targher, Ming-Hua Zheng, Wah-Kheong Chan, Shlomo Vinker, Takumi Kawaguchi, Laurent Castera, Yusuf Yilmaz, Marko Korenjak, C. Wendy Spearman, Mehmet Ungan, Melissa Palmer, Mortada El-Shabrawi, Hans-Juergen Gruss, Jean-Francois Dufour, Anil Dhawan, Heiner Wedemeyer, Jacob George, Luca Valenti, Yasser Fouad, Manuel Romero-Gomez, Mohammed Eslam
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Sergi Guixe-Muntet, Louise Biquard, Gyongyi Szabo, Jean-Francois Dufour, Frank Tacke, Sven Francque, Pierre-Emmanuel Rautou, Jordi Gracia-Sancho
Summary: This review summarizes and discusses the pathobiological role of PPARs in cardiovascular diseases, with a special focus on their impact and therapeutic potential in NAFLD and NASH. The importance of evaluating cardiovascular disease in the context of NASH trials is emphasized.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Stephan Buch, Hamish Innes, Philipp Ludwig Lutz, Hans Dieter Nischalke, Jens U. Marquardt, Janett Fischer, Karl Heinz Weiss, Jonas Rosendahl, Astrid Marot, Marcin Krawczyk, Markus Casper, Frank Lammert, Florian Eyer, Arndt Vogel, Silke Marhenke, Johann von Felden, Rohini Sharma, Stephen Rahul Atkinson, Andrew McQuillin, Jacob Nattermann, Clemens Schafmayer, Andre Franke, Christian Strassburg, Marcella Rietschel, Heidi Altmann, Stefan Sulk, Veera Raghavan Thangapandi, Mario Brosch, Carolin Lackner, Rudolf E. Stauber, Ali Canbay, Alexander Link, Thomas Reiberger, Mattias Mandorfer, Georg Semmler, Bernhard Scheiner, Christian Datz, Stefano Romeo, Stefano Ginanni Corradini, William Lucien Irving, Joanne R. Morling, Indra Neil Guha, Eleanor Barnes, M. Azim Ansari, Jocelyn Quistrebert, Luca Valenti, Sacha A. Mueller, Marsha Yvonne Morgan, Jean-Francois Dufour, Jonel Trebicka, Thomas Berg, Pierre Deltenre, Sebastian Mueller, Jochen Hampe, Felix Stickel
Summary: This study identifies rs2242652 in TERT as a novel protective factor for HCC in patients with alcohol-related cirrhosis.
Article
Gastroenterology & Hepatology
Julia Dietz, Beat Muellhaupt, Peter Buggisch, Christiana Graf, Kai-Henrik Peiffer, Katrin Matschenz, Joern M. Schattenberg, Christoph Antoni, Stefan Mauss, Claus Niederau, Thomas Discher, Janina Trauth, Georg Dultz, Julian Schulze zur Wiesch, Felix Piecha, Hartwig Klinker, Tobias Mueller, Thomas Berg, Christoph Neumann-Haefelin, Christoph P. Berg, Stefan Zeuzem, Christoph Sarrazin
Summary: This study evaluated the long-term persistence of resistance-associated substitutions (RASs) in HCV patients treated with DAAs. Low-to medium-level RASs were found to persist over time, while high-level resistant RASs gradually disappeared. Different patterns of RAS persistence according to HCV subtype could have implications for retreatment with first-generation DAAs and for global HCV elimination goals.
JOURNAL OF HEPATOLOGY
(2023)
Article
Surgery
Melisa Dirchwolf, Chiara Becchetti, Susanne Stampf, Christa Haldimann, Franz Immer, Franziska Beyeler, Christian Toso, Philipp Dutkowski, Daniel Candinas, Jean-Francois Dufour, Vanessa Banz
Summary: This study analyzed the impact of perceived liver donor quality on transplant recipient outcomes. It included all deceased liver donors during 2008-2018 in the Swiss Transplant Cohort Study. The results showed that perceived poor-quality liver donors accounted for 19.2% of the total, but this did not significantly affect re-listing or death within the first week and first year post-transplant.
ANZ JOURNAL OF SURGERY
(2023)
Article
Immunology
Marta Magaz, Heloise Giudicelli-Lett, Oana Nicoara-Farcau, Neil Rajoriya, Ashish Goel, Karlien Raymenants, Sophie Hillaire, Gonzalo Crespo, Luis Tellez, Laure Elkrief, Constantino Fondevila, Lara Orts, Filipe Nery, Akash Shukla, Helene Larrue, Yiliam Fundora, Helena Degroote, Victoria Aguilera, Elba LLop, Laura Turco, Federica Indulti, Stefania Gioia, Giulia Tosetti, Niccolo Bitto, Chiara Becchetti, Edilmar Alvarado, Cristina Roig, Raquel Diaz, Michael Praktiknjo, Anna-Lena Konicek, Guillem Soy, Pol Olivas, Jose Ignacio Fortea, Helena Masnou, Angela Puente, Alba Ardevol, Carmen Alvarez-Navascues, Marta Romero, Bernhard Scheiner, Georg Semmler, Mattias Mandorfer, Filipe Damiao, Anna Baiges, Fanny Turon, Macarena Simon-Talero, Carlos Gonzalez-Alayon, Alba Diaz, Angeles Garcia-Criado, Andrea de Gottardi, Enric Reverter, Annabel Blasi, Joan Genesca, Olivier Roux, Claire Francoz, Carlos Noronha Ferreira, Thomas Reiberger, Manuel Rodriguez, Rosa Maria Morillas, Javier Crespo, Jonel Trebicka, Rafael Banares, Candid Villanueva, Annalisa Berzigotti, Massimo Primignani, Vincenzo La Mura, Oliviero Riggio, Filippo Schepis, Bogdan Procopet, Xavier Verhelst, Jose Luis Calleja, Christophe Bureau, Agustin Albillos, Frederik Nevens, Virginia Hernandez-Gea, Dhiraj Tripathi, Pierre-Emmanuel Rautou, Francois Durand, Juan Carlos Garcia-Pagan
Summary: This study aimed to identify features associated with post-LT outcomes in PSVD. The results showed that patients without associated severe conditions had better survival rates after LT, while pre-LT high bilirubin levels and creatinine >100 μmol/L were associated with poor survival.
Article
Gastroenterology & Hepatology
Vijosh V. Kumar, Prajob Geevarghese Prasad, Jeby Jacob, Harikumar Nair
Summary: Living liver donation is an effective method to reduce waitlist mortality, especially with limited deceased donors. Right lobe adult-to-adult living donor liver transplantation has been well studied in terms of short-term surgical outcomes and complications. However, there is a lack of data on the long-term health of donors' remnant liver.
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Iulia Minciuna, Suchira Gallage, Mathias Heikenwalder, Shira Zelber-Sagi, Jean-Francois Dufour
Summary: NASH, a chronic liver disease that can progress to end-stage liver disease and HCC, can be effectively treated with intermittent fasting, which not only induces weight loss but also reduces inflammation and oxidative stress.
Article
Gastroenterology & Hepatology
Marco Spadaccini, Cesare Hassan, Emanuele Rondonotti, Giulio Antonelli, Gianluca Andrisani, Gianluca Lollo, Francesco Auriemma, Federico Iacopini, Antonio Facciorusso, Roberta Maselli, Alessandro Fugazza, Irene Maria Bambina Bergna, Fabrizio Cereatti, Benedetto Mangiavillano, Franco Radaelli, Francesco Di Matteo, Seth A. Gross, Prateek Sharma, Yuichi Mori, Michael Bretthauer, Douglas K. Rex, Alessandro Repici, CERTAIN Study Grp
Summary: In this multicenter randomized trial, the combination of CADe and Endocuff during colonoscopy was found to increase adenoma detection rate and the number of adenomas detected per colonoscopy compared to CADe alone, without increasing withdrawal time. The integrity of colonoscopy was not compromised with this combination.
Article
Medicine, General & Internal
Francesco Negro, Beat Mullhaupt, David Semela, Sarah Blach, Philip Bruggmann, Andrea De Gottardi, Jean-Francois Dufour, Montserrat Fraga, Antonio Galante, Homie Razavi, Joana Vieira Barbosa, Devin Razavi-Shearer
Summary: This study examines the current and future disease burden of chronic hepatitis B virus (HBV) infection in Switzerland, considering the impact of migration. The study found that although the prevalence of HBV infection is decreasing in Switzerland, the current levels of diagnosis and treatment remain below global health sector strategy targets.
SWISS MEDICAL WEEKLY
(2023)