Journal
BIOACTIVE MATERIALS
Volume 21, Issue -, Pages 175-193Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2022.08.001
Keywords
Hydrogel; Mandibular defect; Tissue engineering; Injectable materials; Bone regeneration
Ask authors/readers for more resources
This article reviews current clinical treatments and pathological resorption patterns of mandibular defects, summarizes hydrogel-related mandibular tissue engineering, and updates on the advanced fabrication of hydrogels. Advanced hydrogel systems hold great potential for more biocompatible, effective, and personalized mandibular reconstruction.
Mandibular defect becomes a prevalent maxillofacial disease resulting in mandibular dysfunctions and huge psychological burdens to the patients. Considering the routine presence of oral contaminations and aesthetic restoration of facial structures, the current clinical treatments are however limited, incapable to reconstruct the structural integrity and regeneration, spurring the need for cost-effective mandibular tissue engineering. Hydrogel systems possess great merit for mandibular reconstruction with precise involvement of cells and bioactive factors. In this review, current clinical treatments and distinct mode(s) of mandible formation and pathological resorption are summarized, followed by a review of hydrogel-related mandibular tissue engineering, and an update on the advanced fabrication of hydrogels with improved mechanical property, antibacterial ability, injectable form, and 3D bioprinted hydrogel constructs. The exploration of advanced hydrogel systems will lay down a solid foundation for a bright future with more biocompatible, effective, and personalized treatment in mandibular reconstruction.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available