Article
Rheumatology
Ling-Ying Ma, Bing Wu, Xue-Juan Jin, Ying Sun, Xiu-Fang Kong, Zong-Fei Ji, Rong-Yi Chen, Xiao-Meng Cui, Hong-Cheng Shi, Lin-Di Jiang
Summary: This study aims to investigate the utility of F-18-FDG-PET/CT in assessing disease activity in Takayasu arteritis. The results showed that the new model combining SUVmean, ESR score, and IL-2R levels demonstrated superiority over conventional methods in identifying active disease.
Article
Oncology
Suk-Hyun Lee, Jee-Soo Park, Hyunjeong Kim, Dongwoo Kim, Seung-Hwan Lee, Won-Sik Ham, Woong-Kyu Han, Young-Deuk Choi, Mijin Yun
Summary: The heterogeneous uptake of both F-18 FDG and C-11 methionine on PET/CT in renal cell carcinomas is associated with higher grades of cancer. The metabolic tumour volume on F-18 FDG PET/CT but not C-11 methionine PET/CT is significant in predicting advanced-stage renal cell carcinoma. These metabolic features derived from PET/CT imaging may aid in the development of new drugs targeting glucose and amino acid metabolic pathways.
Article
Cardiac & Cardiovascular Systems
Chaitanya Rojulpote, Abhijit Bhattaru, Christopher Jean, Sarah L. Adams, Vandan Patel, Mahesh K. Vidula, Senthil Selvaraj, Jacob Dubroff, Eliot Peyster, Caitlin B. Clancy, Karen Patterson, Francis E. Marchlinski, Milton Rossman, Lee Goldberg, Paco E. Bravo
Summary: This study investigated the effect of immunosuppressive therapy and biopsy status on myocardial FDG-PET/CT in assessing treatment response in patients with suspected cardiac sarcoidosis. The results showed that a favorable treatment response was more common when using moderate-to-high intensity prednisone dose, and individuals with biopsy-proven sarcoidosis and preserved systolic function were less likely to experience adverse outcomes during follow-up.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Urology & Nephrology
Sarah R. Ottenhof, Rosa S. Djajadiningrat, Michelle W. J. Versleijen, Maarten L. Donswijk, Vincent van der Noort, Oscar R. Brouwer, Niels M. Graafland, Erik Vegt, Simon Horenblas
Summary: FDG-PET/CT has high diagnostic value for staging pelvic lymph nodes and detecting distant metastases in high-risk penile cancer patients. It has high sensitivity and negative predictive value for pelvic lymph node staging, as well as a high positive predictive value for the detection of distant metastases.
EUROPEAN UROLOGY FOCUS
(2022)
Article
Oncology
Xiaojun Xu, Xun Sun, Ling Ma, Huangqi Zhang, Wenbin Ji, Xiaotian Xia, Xiaoli Lan
Summary: This study aimed to investigate the feasibility of predicting progression-free survival (PFS) in breast cancer patients using pretreatment F-18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) radiomics signature and clinical parameters. The study found that the integrated clinical-radiomics (ICR) model, which combined clinical parameters and preoperative FDG PET/CT imaging, was able to independently predict PFS in breast cancer patients, and was superior to the clinical model alone and rad-score alone.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Hyein Ahn, Geum Jong Song, Si-Hyong Jang, Hyun Ju Lee, Moon-Soo Lee, Ji-Hye Lee, Mee-Hye Oh, Geum Cheol Jeong, Sang Mi Lee, Jeong Won Lee
Summary: Radiomic analysis using textural features extracted from FDG PET/CT images can predict metastasis and prognosis in gastric cancer patients. This study found significant correlations between textural features on FDG PET/CT, histopathological findings, and recurrence-free survival in advanced gastric cancer.
Article
Cardiac & Cardiovascular Systems
Joao Borges-Rosa, Manuel Oliveira-Santos, Rodolfo Silva, Andreia Gomes, Jose de Almeida, Gracinda Costa, Lino Goncalves, Maria Joao Ferreira
Summary: In patients with biopsy-proven sarcoidosis, cardiac involvement detected by [18F]FDG-PET or CMR is associated with a higher risk of cardiovascular events, regardless of symptoms. Patients with probable CS had a higher prevalence of heart failure, atrial fibrillation, coronary disease, and valvular disease compared to those without cardiac involvement. Probable CS patients had significantly higher rates of heart failure hospitalizations, uncontrolled arrhythmias, and pacemaker implantation during follow-up, with a trend towards increased all-cause mortality.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Seyed Ali Mirshahvalad, Aruz Mesci, Vanessa Murad, Andres Kohan, Claudia Ortega, Patrick Veit-Haibach, Ur Metser
Summary: This study conducted a meta-analysis to evaluate the diagnostic and prognostic value of PET in anal canal cancer patients. The results showed that PET had high sensitivity and specificity in distinguishing T3/T4 stages and detecting metastatic disease. PET also showed good sensitivity and specificity in therapy response assessment. Furthermore, pre-treatment total metabolic tumour volume was found to be predictive of survival, and complete metabolic response was associated with better prognosis. Overall, PET may be a valuable tool in therapy planning and prognostic assessment for anal canal cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Akihiko Sakata, Yasutaka Fushimi, Yoshiki Arakawa, Yoichi Shimizu, Yuji Nakamoto
Summary: Solitary intracranial tuberculomas are rare and often misdiagnosed as brain tumors. We present a case of intracranial tuberculous granuloma mimicking a high-grade glioma with avid uptake on F-18-fluoromisonidazole PET/CT. The hypoxic and necrotic condition inside the tuberculous granuloma may contribute to the high accumulation of F-18-fluoromisonidazole in this case.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wan-Ming Chen, Mingchih Chen, Jeng-Guan Hsu, Tian-Shyug Lee, Ben-Chang Shia, Szu-Yuan Wu
Summary: The use of preoperative PET/CT is associated with a lower risk of death in patients with resectable stage IIIA-IIIB non-small cell lung cancer, but it does not improve survival rates in patients with stage I-II cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Stephan Waelti, Stephan Skawran, Thomas Sartoretti, Moritz Schwyzer, Antonio G. Gennari, Cacilia Mader, Valerie Treyer, Christian J. Kellenberger, Irene A. Burger, Thomas Hany, Alexander Maurer, Martin W. Huellner, Michael Messerli
Summary: This study retrospectively assessed the evolution of administered radiotracer activity for F-18-fluorodeoxyglucose PET/CT or PET/MR in pediatric patients between 2000 and 2021. The results showed that children have benefited from a significant reduction in the administered F-18-FDG dose over the past 20 years without compromising objective image quality.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Bing Wang, Yiduo Xu, Peng Wan, Shan Shao, Feifei Zhang, Xiaoliang Shao, Jianfeng Wang, Yuetao Wang
Summary: There is a significant correlation between atrial FDG uptake and AF, particularly in the right atrium. Atrial FDG uptake is an independent risk factor for stroke, and the addition of high RA SUVmax to the CHA(2)DS(2)-VASc score improves the prediction of stroke in patients with AF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hao-Jun Xie, Xue-Song Sun, Xu Zhang, Bei-Bei Xiao, Da-Feng Lin, Xiao-Ping Lin, Xiao-Fei Lv, Li-Zhi Liu, Feng Han, Ru-Hai Zou, Ji-Bin Li, Wei Fan, Qiu-Yan Chen, Hai-Qiang Mai, Lin-Quan Tang
Summary: The study evaluated the superiority of MRI, [F-18]FDG PET/CT, and M-PET/CT in prognostic stratification of nasopharyngeal carcinoma (NPC) patients based on long-term survival evidence. The results showed that MRI performed better in T stage, while [F-18]FDG PET/CT performed better in N and M stage. The TNM staging method involving T-MRI + N-PET/CT + M-PET/CT significantly improved NPC patients' long-term prognostic stratification.
EUROPEAN RADIOLOGY
(2023)
Article
Chemistry, Medicinal
Chunmei Lu, Xiuting Wang, Qiqi Wang, Lixia Zhang, Jianguo Lin, Ling Qiu
Summary: Legumain is overexpressed in several cancers and serves as an important biomarker for cancer diagnosis. In this study, a novel radioactive tracer [F-18]SF-AAN was designed and synthesized for positron emission tomography (PET) imaging, targeting legumain. The tracer showed specificity in detecting legumain activity in vitro and in vivo, making it a promising tool for the diagnosis of legumain-related diseases.
Review
Biochemistry & Molecular Biology
Miikka-Juhani Honka, Eleni Rebelos, Simona Malaspina, Pirjo Nuutila
Summary: This review explores the use of PET in evaluating hepatic metabolism, haemodynamics, and cancer. F-18-FDG is the most commonly used tracer for assessing glucose uptake and endogenous glucose production. Other tracers such as F-18-FTHA, C-11-Palmitate, and C-11-Acetate have been applied for measuring fatty acid uptake rates, blood flow, and oxidation in the liver. O-15 labelled water is used for quantifying hepatic perfusion. The challenges and modelling approaches in utilizing PET for assessing hepatic metabolism are also discussed.