Article
Pharmacology & Pharmacy
Seyed Ebrahim Alavi, Urooj Bakht, Maedeh Koohi Moftakhari Esfahani, Hossein Adelnia, Seyed Hossein Abdollahi, Hasan Ebrahimi Shahmabadi, Aun Raza
Summary: This study demonstrates the use of PEGylated nanostructured lipid carrier nanoparticles as a promising approach for improving the oral delivery and efficacy of trimethoprim/sulfamethoxazole (TMP/SMZ) for the treatment of MRSA skin infection. The nanoformulation was found to have a controlled release of drugs at intestinal pH, decreased drug toxicity, enhanced drug permeability, and improved antibacterial effects. The stability of the nanoparticles was also shown. Overall, this study highlights the potential of PEGylated NLC nanoparticles in improving the treatment of MRSA skin infection.
Review
Pharmacology & Pharmacy
Adila Nazli, David L. He, Dandan Liao, Muhammad Zafar Irshad Khan, Chao Huang, Yun He
Summary: Antibiotic resistance is a global health issue and potential risk for society. Traditional antibiotic therapy has limitations, but drug-delivery systems and innovative approaches offer hope for addressing these issues.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Stephanie Andrade, Maria J. Ramalho, Silvio B. Santos, Luis D. R. Melo, Rita S. Santos, Nuno Guimaraes, Nuno F. Azevedo, Joana A. Loureiro, Maria C. Pereira
Summary: Antimicrobial resistance (AMR) poses a significant threat to global health, with Methicillin-resistant Staphylococcus aureus (MRSA) being a major concern. Nanoparticles (NPs) have emerged as a promising approach for treating MRSA infections, acting as antibacterial agents or drug delivery systems. The targeted delivery of NPs to the infection site is crucial for effective treatment, allowing for high concentrations of therapeutics while minimizing toxicity to healthy cells and reducing AMR emergence and disruption of the healthy microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Carolyn B. Ibberson, Juan P. Barraza, Avery L. Holmes, Pengbo Cao, Marvin Whiteley
Summary: A hallmark of microbial ecology is the interaction between microbial communities in chronic wounds, specifically between Staphylococcus aureus and Pseudomonas aeruginosa. The spatial structure of these microbes plays a significant role in disease progression and antimicrobial tolerance.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Pharmacology & Pharmacy
Mehrab Pourmadadi, Arian Farokh, Erfan Rahmani, Mohammad Mahdi Eshaghi, Ali Aslani, Abbas Rahdar, Luiz Fernando Romanholo Ferreira
Summary: Hydrogels are important materials in medical research, particularly in the field of drug delivery systems. Polyacrylic acid (PAA) is a notable polymer in this regard, due to its biodegradability and pH-sensitivity. PAA's potential in cancer therapy and oral drug delivery has led to extensive research, with a focus on target-specific carriers based on PAA and its derivatives. This review provides an overview of the formation, properties, and recent developments of PAA-contained drug carriers for cancer therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Immunology
Pernille Ommen, Line Hansen, Bente K. Hansen, Hieu Vu-Quang, Jorgen Kjems, Rikke L. Meyer
Summary: In this study, an aptamer-targeted liposomal drug delivery system was developed to eradicate Staphylococcus aureus biofilm infections in vitro.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nikita Yabbarov, Elena Nikolskaya, Maria Sokol, Mariia Mollaeva, Margarita Chirkina, Irina Seregina, Mikhail Gulyaev, Yury Pirogov, Rem Petrov
Summary: This study demonstrates a dual-targeting drug delivery strategy that enhances the therapeutic efficacy by simultaneously targeting tumor endothelium and cell surface receptors. By functionalizing the nanodevice with selectin ligand and alpha-fetoprotein receptor-binding peptide, the strategy increases the accumulation and antitumor effect of the drug in tumor tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Shen Cheng, Susheel Kumar Nethi, Mahmoud Al-Kofahi, Swayam Prabha
Summary: Nano-engineered mesenchymal stem cells (nano-MSCs) are potentially effective targeted drug delivery platforms for treating solid tumors, but their pharmacokinetic-pharmacodynamic relationship requires quantitative description to optimize therapeutic efficacy. A mechanism-based preclinical PK-PD model was developed to characterize the PK-PD relationship of nano-MSCs in orthotopic A549 human lung tumors in SCID Beige mice, showing potential for improving anti-tumor efficacy with dosage adjustments and modulation of exocytosis rates.
Review
Nanoscience & Nanotechnology
Ran Chen, Tingting Wang, Jie Song, Daojun Pu, Dan He, Jianjun Li, Jie Yang, Kailing Li, Cailing Zhong, Jingqing Zhang
Summary: Antiviral drugs play a crucial role in fighting viruses, including COVID-19, but their use is often limited by poor oral bioavailability and low efficacy. Studying the metabolism and pharmacokinetic characteristics of AvDs can help improve their effectiveness and combat drug resistance.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Pharmacology & Pharmacy
Hong-can Ren, Jian-guo Sun, A. Ji-ye, Sheng-hua Gu, Jian Shi, Feng Shao, Hua Ai, Jing-wei Zhang, Ying Peng, Bei Yan, Qing Huang, Lin-sheng Liu, Yang Sai, Guang-ji Wang, Cheng-guang Yang
Summary: This study aimed to investigate the pharmacokinetics of the deglycosylation metabolite PPD following Rh2 administration and develop a mechanism-based pharmacokinetic model. Results showed that a certain percentage of Rh2 was transformed into PPD and entered systemic circulation, highlighting the importance of studying deglycosylation kinetics for future pharmacokinetic studies of similar drugs.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Lu Tang, Jing Li, Qingqing Zhao, Ting Pan, Hui Zhong, Wei Wang
Summary: Nanotechnology plays a crucial role in cancer treatment, improving drug delivery efficiency and pharmacokinetics. Small molecule drugs and biological macromolecule drugs are the main types of anticancer agents, with nano-encapsulation technology playing a key role in their delivery.
Article
Microbiology
Adriana Fernandes, Carla Ramos, Victor Monteiro, Joana Santos, Paulo Fernandes
Summary: This study detected the presence of Staphylococcus aureus (S. aureus) on food handlers. The results showed that 11% of the samples were positive for S. aureus. Among them, 44.4% of the strains showed resistance to erythromycin. Furthermore, at least one virulence or toxin gene was detected in 61.1% of the strains.
Article
Infectious Diseases
Ziga Ude, Nils Flothkotter, Gerard Sheehan, Marian Brennan, Kevin Kavanagh, Celine J. Marmion
Summary: Researchers have developed two novel metallo-antibiotics that show potent antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus, while also exhibiting good tolerability in larvae. These complexes affect various proteins involved in bacterial virulence, pathogenesis, and DNA repair mechanisms.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Chemistry, Multidisciplinary
Chenxing Fu, Ying Tao, Haoting Chen, Minghui Li, Yafang Xiao, Yuying Yao, Jing Ma, Xiaodong Ning, Weirun Li, Jun Zheng, Songbo Dong, Guoqin Chen, Feng Cao, Caiwen Ou, Lu Liu, Weisheng Guo
Summary: A bio-activatable nano-shuttle based on human serum albumin was developed, containing curcumin to precisely inhibit the progression of atherosclerosis. The nano-shuttles were engulfed by inflammatory monocytes and co-migrated with them towards the plaques, where they were activated to release curcumin in response to the generation of legumain. Treatment assessments on mice showed that the nano-shuttles effectively inhibited the progression of atherosclerosis without any adverse effects. The selective accumulation and specific drug activation of the nano-shuttles in plaques can provide an advanced therapeutic strategy for preventing atherosclerotic cardiovascular disease.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Eman Elhassan, Nikita Devnarain, Mahir Mohammed, Thirumala Govender, Calvin A. Omolo
Summary: Hybrid nanoparticles are considered superior alternatives for delivering antibiotics and targeting infections, resulting in eradication of bacterial infections and overcoming antimicrobial resistance. This review provides an up-to-date overview of various types of hybrid nanoparticles and their design approaches, nanomaterial construction, drug release mechanisms, and enhanced antibacterial efficacy. Future strategies to improve hybrid nanosystems for treating bacterial infections and overcoming antibiotic resistance are also highlighted.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Environmental Sciences
Asmaa Bouyahya, Berthe-Sandra Sembo-Backonly, Audrey Favrelle-Huret, Sebastien Balieu, Frederic Guillen, Valerie Mesnage, Carole Karakasyan-Dia, Mohammed Lahcini, Didier Le Cerf, Geraldine Gouhier
Summary: A new hybrid material was developed through innovative supramolecular tripartite association, showing excellent inclusion properties and extraction efficiency, which is significant for green analytical chemistry.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Microbiology
Brandon Robin, Marion Nicol, Hung Le, Ali Tahrioui, Annick Schaumann, Jean-Baptiste Vuillemenot, Delphine Vergoz, Olivier Lesouhaitier, Thierry Jouenne, Julie Hardouin, Anais Potron, Valerie Perrot, Emmanuelle De
Summary: Acinetobacter baumannii is a problematic bacterial pathogen that is resistant to antibiotics and can form biofilms. The MacAB-TolC system is involved in biofilm formation in A. baumannii.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemical Research Methods
Salome Sauvage, Charlotte Gaviard, Ali Tahrioui, Laurent Coquet, Hung Le, Stephane Alexandre, Ahmed Ben Abdelkrim, Emeline Bouffartigues, Olivier Lesouhaitier, Sylvie Chevalier, Thierry Jouenne, Julie Hardouin
Summary: In this study, the impact of various carbon source supplementations on the physiology of the Pseudomonas aeruginosa PA14 strain was investigated using a global proteomic approach and phenotypic assays. The results showed that citrate supplementation enhanced the virulence, motility, biofilm development, and antibiotic resistance of the strain.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Polymer Science
Mathieu Madau, Gaelle Morandi, Vincent Lapinte, Didier Le Cerf, Virginie Dulong, Luc Picton
Summary: HA-based thermo-responsive hydrogels were obtained through functionalization with PiPrOx-co-PnBuOx copolymers. The hydrogel transition temperature can be controlled by varying the monomeric composition.
Article
Chemistry, Multidisciplinary
Meriem Aitouguinane, Zainab El Alaoui-Talibi, Halima Rchid, Imen Fendri, Slim Abdelkafi, Mohamed Didi Ould El-Hadj, Zakaria Boual, Pascal Dubessay, Philippe Michaud, Didier Le Cerf, Christophe Rihouey, Guillaume Pierre, Cedric Delattre, Cherkaoui El Modafar
Summary: Sulfated glycoproteins extracted from Moroccan green seaweed can induce natural defense metabolism in tomato seedlings. These extracts stimulate phenylalanine ammonia-lyase activity, polyphenol accumulation, and lignin content increase.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Asma Chetouani, Meriem Elkolli, Hichem Haffar, Henni Chader, Farid Riahi, Tony Varacavoudin, Didier Le Cerf
Summary: Gelatin cross-linked with oxidized pectin shows potential as a scaffold material for tissue engineering, with improved wound healing activity observed in animal models.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Huu Van Le, Virginie Dulong, Luc Picton, Didier Le Cerf
Summary: A novel kind of thermoresponsive polyelectrolyte complex-based nanogels (PEC-NGs) were developed by mixing hyaluronic acid functionalized with Jeffamine M-2005 and either DEAE-D or PLL. The presence of M2005 grafts led to PEC-NGs with larger particle size, lower net surface charge, and thermoresponsiveness. Replacing DEAE-D with PLL improved stability against salinity and encapsulation of curcumin.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Medicinal
Meriem Aitouguinane, Zainab El Alaoui-Talibi, Halima Rchid, Imen Fendri, Slim Abdelkafi, Mohamed Didi Ould El-Hadj, Zakaria Boual, Didier Le Cerf, Christophe Rihouey, Christine Gardarin, Pascal Dubessay, Philippe Michaud, Guillaume Pierre, Cedric Delattre, Cherkaoui El Modafar
Summary: The study investigated the ability of alginates extracted from two Moroccan brown seaweeds and their derivatives to induce phenolic metabolism in tomato seedlings. Elicitation was done by foliar spraying the seaweed alginates on tomato seedlings and evaluating their effects on PAL activity, polyphenol, and lignin production. It was found that low-molecular-weight alginates were more effective in inducing natural defenses in tomato seedlings compared to the alginate polymers. These findings suggest that low-molecular-weight alginates may have potential as a stimulant for plant natural defenses.
Article
Polymer Science
Gwendoline Christophe, Xiaoyang Hou, Emmanuel Petit, Mounir Traikia, Didier Le Cerf, Christophe Rihouey, Christine Gardarin, Cedric Delattre, Philippe Michaud, Guillaume Pierre, Pascal Dubessay
Summary: This study identified Peteryoungia rosettifformans as a wild producer of an exopolysaccharide related to glucuronan. Structural and biochemical analyses revealed that the polysaccharide had a molecular mass of 1.85 x 10(5) Da and was partially O-acetylated at C-2 and/or C-3 positions. The concentration of Mg2+ ions in the cultivation medium was found to impact the structure of the polysaccharide.
Article
Pharmacology & Pharmacy
Huu Van Le, Virginie Dulong, Luc Picton, Didier Le Cerf
Summary: The lyophilization of nanogels allows for long-term conservation and adjustment of their concentration and dispersant type. This study investigated the effects of formulation aspects on the integrity of polyelectrolyte complex nanogels after lyophilization and reconstitution. The best approach for freeze-drying thermoresponsive PEC-NGs was determined, and it was found that freeze-drying PEC-NG suspensions prepared at a relatively low polymer concentration with trehalose as a cryoprotectant allowed for homogeneous redispersion of PEC-NGs without significant aggregation.
Article
Biochemistry & Molecular Biology
Manel Sfar, Ghada Souid, Fahad M. M. Alminderej, Zeineb Mzoughi, Yassine El-Ghoul, Christophe Rihouey, Didier Le Cerf, Hatem Majdoub
Summary: This study investigated the extraction of polysaccharides from coriander seeds and evaluated their antioxidant and hepatoprotective effects. The structural characterization of the polysaccharide was performed, showing its composition and properties. Results demonstrated that the polysaccharide exhibited significant inhibition of cadmium-induced oxidation damage and protection against Cd hepatocytotoxicity by reducing MDA production and increasing CAT and SOD enzyme levels.
Article
Chemistry, Multidisciplinary
Manel Sfar, Ghada Souid, Zeineb Mzoughi, Didier Le Cerf, Hatem Majdoub
Summary: Polysaccharides from F. vulgare seeds were characterized and found to have antioxidant activity, reducing oxidative damage and hepatotoxicity induced by cadmium. These findings suggest that FPS could be a potential natural antioxidant for the treatment of hepatic diseases.
CHEMISTRY AFRICA-A JOURNAL OF THE TUNISIAN CHEMICAL SOCIETY
(2023)
Article
Biotechnology & Applied Microbiology
Claire Toucheteau, Valentine Deffains, Clement Gaignard, Christophe Rihouey, Celine Laroche, Guillaume Pierre, Olivier Lepine, Ian Probert, Didier Le Cerf, Philippe Michaud, Ingrid Arnaudin-Fruitier, Nicolas Bridiau, Thierry Maugard
Summary: This study isolated and depolymerized exopolysaccharides (EPS) from different microalgae, characterized their structural features, and investigated their effects on collagen activity. The depolymerized EPS forms enhanced collagen production, and the inhibition of collagenase activity was strongly correlated to the sulfate group content of EPS. These findings provide new insights into the dermo-cosmetic potential of microalgae EPS.