Article
Biochemistry & Molecular Biology
Abrar Ul Haq Khan, Melinda Blimkie, Doo Seok Yang, Mandy Serran, Tyler Pack, Jin Wu, Ji-Young Kang, Holly Laakso, Seung-Hwan Lee, Yevgeniya Le
Summary: LDR significantly influenced the proportion, proliferation, activation, and function of immune cells, particularly NK and T cells, but had no noticeable impact on mammary cancer development. The study also demonstrated the modulation of the cross-talk between NKG2D receptor and its ligands by LDR exposure at different time points.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yu-Fan Liu, Yun Chiang, Feng-Ming Hsu, Chiao-Ling Tsai, Jason Chia-Hsien Cheng
Summary: The combination therapy of radiotherapy and HDAC inhibition increases the expression of NKG2D ligands in HCC cells, enhancing their susceptibility to NK cell-mediated cytotoxicity. This suggests the potential use of combined RT/HDACi and NK cell-directed immunotherapy for HCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Geriatrics & Gerontology
Rongjiao Liu, Qizhi Luo, Weiguang Luo, Ling Wan, Quan Zhu, Xiangli Yin, Xiaofang Lu, Zixuan Song, Leiyan Wei, Zhiqing Xiang, Yizhou Zou
Summary: In this study, a soluble NKCAR was designed to trigger NK cell cytotoxicity by binding with the ligand MICA through the NKG2D receptor expressed on NK cells. The NKCAR showed bifunctional activity, recognizing both the CD20 antigen of target cells and the NKG2D receptor of NKL cells. The soluble NKCAR mediated the killing of CD20(+) Daudi cells in vitro, indicating its potential clinical application for killing target tumor cells.
Review
Cell Biology
Ammad Ahmad Farooqi, Rukset Attar, Ishmuratova Margarita Yulaevna, Rossana Berardi
Summary: Advancements in single-cell RNA sequencing technologies have allowed us to understand the heterogeneity of the immune system and identify different subsets of immune cells in disease and health. The discovery of non-coding RNAs has provided new insights into the regulatory roles of cell signaling pathways in immunology and oncology. The delivery of non-coding RNAs through exosomes to recipient cells has shown promising potential for rewiring pathways and protein networks. A broader understanding of the regulation in this system could lead to the development of clinically effective therapeutics.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Reem Alkhayer, Viviane Ponath, Miriam Frech, Till Adhikary, Johannes Graumann, Andreas Neubauer, Elke Pogge von Strandmann
Summary: This study identifies the transcription factor KLF4 as associated with the MICA promoter, and demonstrates that pharmacological activation of KLF4 leads to increased expression of MICA in AML cells. The small compound APTO253, which activates KLF4, also inhibits MYC expression and causes DNA damage in AML cells. The induction of MICA expression renders AML cells more susceptible to NK cell-mediated killing, suggesting a potential therapeutic approach for targeting AML cells.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Medicine, General & Internal
Laura Strobel, Kilian Vomstein, Christiana Kyvelidou, Susanne Hofer-Tollinger, Katharina Feil, Ruben-Jeremias Kuon, Susanne Ebner, Jakob Troppmair, Bettina Toth
Summary: In this study, we found that compared to sRPL patients, sCtrls had higher numbers of CD56(+) and CD56(dim)CD16(bright) cells. Furthermore, sRPL patients had lower numbers of CD56(dim)CD16(bright)NKG2D(+) and CD56(dim)CD16(bright)NKp46(+) compared to sCtrls.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Allergy
Leyla Pur Ozyigit, Esin Cetin Aktas, Yusuf Metin Gelmez, Ayse Bilge Ozturk, Bilun Gemicioglu, Gunnur Deniz
Summary: This study found impaired NK receptor expression, activation, and reduced cytotoxicity in obesity-associated asthma patients. Differences were observed between the early-onset allergic and late-onset non-allergic subtypes of OA in terms of NK cell behavior. These findings could help in tailoring more personalized treatment strategies to address steroid resistance and frequent exacerbations in this patient group.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Biochemical Research Methods
Xiaoming Zhong, Hongqun Liao, Shaowen Hu, Kaiyuan Luo, Huifang Zhu
Summary: The natural product adenanthin significantly promotes the expression of NKG2D ligands in hepatoma cells, improving the killing activity of NK cells against liver cancer cells. This study is the first to report the anti-cancer effects of adenanthin mediated by indirect activation of NK cells. Adenanthin may be used as a sensitizing agent for NK cells in tumor immunotherapy.
MOLECULAR AND CELLULAR PROBES
(2021)
Article
Immunology
Maria Giovanna Desimio, Andrea Finocchi, Gigliola Di Matteo, Silvia Di Cesare, Carmela Giancotta, Francesca Conti, Luciana Chessa, Maria Piane, Davide Montin, Marta Dellepiane, Paolo Rossi, Caterina Cancrini, Margherita Doria
Summary: NK cells in A-T patients show reduced NKG2D expression, possibly contributing to increased susceptibility. The abnormal expression of NKG2D in A-T patients may be associated with disease progression.
CLINICAL IMMUNOLOGY
(2021)
Review
Immunology
Giorgio Santoni, Consuelo Amantini, Matteo Santoni, Federica Maggi, Maria Beatrice Morelli, Angela Santoni
Summary: NK cells play a crucial role in immune protection against viruses and tumors by killing target cells and secreting cytokines. Mechanotransduction, mediated by actin cytoskeleton, regulates NK cell functions such as adhesion, migration, and tissue infiltration. Further research on mechanotransduction may lead to new immunotherapeutic approaches tailored for NK cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Takahiro Uchida, Muneharu Yamada, Dan Inoue, Tadasu Kojima, Noriko Yoshikawa, Shingo Suda, Hidenobu Kamohara, Takashi Oda
Summary: A retrospective evaluation of SA-AKI patients showed that CD56(+) T cells are involved in the disease processes of SA-AKI through effector molecules such as FasL or perforin. However, the antigen-presenting capacity and phagocytic activity of monocytes in patients were significantly decreased and did not recover soon after the initiation of CRRT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Kevin J. Lopez, John Paul Spence, Wei Li, Wenjun Zhang, Barry Wei, Arthur A. Cross-Najafi, James R. Butler, David K. C. Cooper, Burcin Ekser, Ping Li
Summary: This study clarifies the role of pULBP-1 in the interaction between NK cells and pig cells. The results demonstrate that pULBP-1 is not a crucial factor in initiating xenogeneic human NK cell activation.
Article
Biochemistry & Molecular Biology
Fei Gao, Jianjun Han, Li Jia, Jun He, Yun Wang, Mi Chen, Xiaojun Liu, Xia He
Summary: miR-30c enhances NK cell cytotoxicity to lung cancer cells by decreasing GALNT7 and inactivating the PI3K/AKT pathway, suggesting that regulating miR-30c expression may be a promising approach for enhancing NK cell-based antitumor therapies.
Review
Oncology
Zahra Hatami, Zahra Sadat Hashemi, Mohamad Eftekhary, Ala Amiri, Vahid Karpisheh, Kaveh Nasrollahi, Reza Jafari
Summary: Chimeric antigen receptor natural killer cells (CAR-NK) have potential in off-the-shelf cellular therapy for solid tumors and malignancy. However, their development is restricted due to immune surveillance uncertainty and cytotoxicity challenge. Natural killer cell-derived exosome (NK-Exo) combines targeted cellular therapies with non-toxic exosomes for cancer immunotherapy.
CANCER CELL INTERNATIONAL
(2023)
Article
Cell Biology
Hanna Kim, Jae-Eun Byun, Suk Ran Yoon, Hashem Koohy, Haiyoung Jung, Inpyo Choi
Summary: The study found that SARS-CoV-2 S protein peptides can bind to the NKG2D receptor on NK cells, enhancing immune responses by increasing NK cytotoxicity towards lung cancer cells and stimulating IFN-gamma production. This novel interaction between SARS-CoV-2 and NK cells may have potential clinical applications as a therapeutic target for COVID-19.
CELLULAR IMMUNOLOGY
(2022)
Article
Plant Sciences
Lan Zhang, Zheng Zhang, Golam Jalal Ahammed, Xiaorong Wang, Huihan Fang, Peng Yan, Li-Ping Zhang, Shibei Ge, Jianyu Fu, Wen-Yan Han, Xin Li
Summary: 24-epibrassinolide (EBR) can improve tea resistance against the fungal pathogen Colletotrichum fructicola by inducing lignin synthesis in tea leaves.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Green & Sustainable Science & Technology
Lifang Peng, Jiawei Wang, Yinghua Huang, Xiaorong Wang
Summary: Drawing on moral disengagement theory and liquid consumption theory, this study investigated and tested a conceptual model of guests' unethical behavior in peer-to-peer (P2P) accommodation. The study found that self-construal has both positive and negative effects on guests' unethical behavior, and this relationship is mediated by moral disengagement and moderated by perceived consumption liquidity.
JOURNAL OF SUSTAINABLE TOURISM
(2023)
Article
Automation & Control Systems
Weijia Zheng, YangQuan Chen, Xiaohong Wang, Meijin Lin, Jing Guo
Summary: Fractional order PID (FOPID) controller offers more flexibility in design options compared to integer order PID (IOPID) controller. However, in practical implementation, it is necessary to select achievable design specifications and controller parameters. This study collects and analyzes the complete achievable regions of design specifications and models the selectable integral and derivative orders of the FOPID controller. A synthesis method is proposed to achieve the desired flat-phase characteristic.
MEASUREMENT & CONTROL
(2023)
Article
Automation & Control Systems
Xiaojing Wang, Guangqiang Shi, Meizhen Liu, Yarning Feng
Summary: A robust control strategy based on Adaboost prediction was proposed to improve the robustness and low-speed performance of an electro-hydraulic servo system. By using RBF neural network and H-infinity control theory, the system's feedback mechanism and robust controller were designed to effectively enhance the system's low-speed performance and anti-interference ability.
MEASUREMENT & CONTROL
(2023)
Article
Obstetrics & Gynecology
Linli Hu, Jieqiang Lv, Qianhong Ma, Xiujuan Chen, Xiaohong Wang, Xiaoyan Liang, Dingfei Xu, Yanping Li, Yuanhua Huang, Lina Hu, Xiaohui Deng, Jing Wei, Feng Zhou, Songying Zhang, Jie Wang, Fang Ma, Yingpu Sun
Summary: The study aimed to compare the equivalence of QL1012 and Gonal-f((R)) in ovarian stimulation for assisted reproductive technology. The results showed that there were no significant differences between QL1012 and Gonal-f((R)) in the primary endpoint of oocytes retrieved, and they had similar safety profiles.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Obstetrics & Gynecology
Jie Dong, Qian Xu, Shuqiang Chen, Hui Lei, Jingjing Wang, Song Yan, Chenxi Qian, Xiaohong Wang
Summary: "Offspring conceived by assisted reproductive technologies (ART) have an increased risk of gestational complications, which are related to placental dysfunction. This study used proteomics and phospho-proteomics to investigate the underlying mechanisms responsible for the changes in ART placentas. The findings suggest that ART leads to altered cell junctions, renin-angiotensin system, amino acid transport, and increased mTOR signaling in mouse placentas."
REPRODUCTIVE SCIENCES
(2023)
Article
Clinical Neurology
Jiacheng Liu, Liying Yang, Yue Zheng, Chuanyi Kang, Xiaohong Wang, Jingjing Shi, Siyu Qiu, Ying Zhao, Jiahong Yu, Na Zhao
Summary: This study examined the differences in prevalence and associated factors of suicidal ideation (SI) among adolescents with depression between urban and rural areas. The results showed that urban patients had a higher prevalence of SI compared to rural patients, and there were also differences in parental rearing behavior. The study emphasizes the importance of focusing on parenting styles in adolescent patients for early identification and intervention of SI.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Thermodynamics
Yuxuan Zhang, Xiaoqiang Zhai, Fengyuan Zhang, Zhongbin Zhang, Kamel Hooman, Hai Zhang, Xiaolin Wang
Summary: This article proposes a novel carbon capture capsule inspired by red blood cells (RBC) to enhance CO2 hydrate formation kinetics. Compared to spherical capsules, the RBC-shaped capsule shows a 143% higher gas uptake efficiency. The study also investigates the effects of initial pressure and capsule size on CO2 hydrate formation kinetics.
Article
Environmental Sciences
Yuqin Wang, Wenfu Zhu, Guangyi Zhao, Guangzheng Ye, Yujun Jiao, Xiaohong Wang, Fan Yao, Weixiao Peng, Haomin Huang, Daiqi Ye
Summary: The influence of lignocellulose contents on the pore structure and distribution characteristics of porous carbon has been investigated. It was found that the microvolumes of ultra-micropores decreased with a decrease in cellulose contents, while mesopores followed the reverse trend. Carbon materials with abundant micropores and narrow mesopores exhibited better adsorption performance, while porous carbon with a hierarchical pore structure showed better regeneration abilities.
ENVIRONMENTAL POLLUTION
(2023)
Article
Instruments & Instrumentation
Hao Chen, Chaoyang Zhao, Zhonghai Wang, Lingli Li, Yanhan Zhou, Jie Zhang, Hongbing Xu, Shikui Cheng, Yuxuan Zhu, Yipo Zhang
Summary: A new hard X-ray (HXR) camera is being designed for the HL-2M tokamak to measure the fast electrons in the energy range of 20-200 keV during RF drive or heating experiments. The camera integrates 63 channels of independent detectors and a composite collimator to reduce background rays. The optimal geometric parameters of the collimator were determined using Geant4 simulation.
JOURNAL OF INSTRUMENTATION
(2023)
Article
Virology
Baiwei Liu, Yu Wang, Xiaoli Wang, Lei Jia, Yi Tian, Hanqiu Yan, Weihong Li, Lingyu Shen, Quanyi Wang, Zhiyong Gao
Summary: Between September 2011 and August 2018, a total of 133,131 acute diarrhoea cases were studied in Beijing. Out of 13,139 specimens collected and tested, 16.84% were positive for NoV. Three different NoV strains, GII.4 Sydney, GII.17, and GII.2, were predominant during different time periods. Excess cases of NoV-associated acute diarrhoea were observed during the predominance periods, ranging from 114.7% to 180.5% increase compared to baseline levels. This study highlights the impact of new NoV variants on gastroenteritis outbreaks.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Environmental Sciences
Yaojun Fan, Quan Su, Xiaohong Wang, Min Fan
Summary: With the acceleration of digital technology construction process, digitization has driven the transformation and upgrading of China's economy and micro businesses. This study aims to investigate whether digitization affects corporate green innovation. The findings reveal that digitization genuinely drives green innovation by easing corporate financing constraints and enhancing corporate awareness of fulfilling social responsibility. The study enriches the related theories of digitization and sustainability and provides empirical evidence for the positive externalities of digitization.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2023)
Article
Environmental Sciences
Sidi Chen, Min Fan, Xiaohong Wang, Yaojun Fan, Sze-Ting Chen, Shichi Ren
Summary: Enterprise managers play a decisive role in management decisions, and the influence of managerial ability on enterprise development has received wide attention. This paper uses Chinese A-share listed companies from 2007 to 2019 as samples to examine the impact of management abilities on corporate performance and studies the moderating effect of compensation incentives on this impact. The findings show a significant positive correlation between managerial ability and listed company performance, which is more pronounced when management has higher compensation incentives.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2023)
Article
Engineering, Environmental
Xiaolei Wang, Dunfeng Si, Yuliang Li, Ning Chen, Guodong Fang, Changyin Zhu, Dongmei Zhou
Summary: This study investigated the effects of alcohols on the degradation of perfluorooctanoic acid (PFOA) using persulfate (PS) based advanced oxidation processes. The results showed that ethanol significantly promoted PFOA degradation in a thermal/PS system. The reaction between ethanol and sulfate radicals (SO4 center dot-) generated from PS activation was found to efficiently degrade PFOA.
Proceedings Paper
Automation & Control Systems
Yan Ming, Wang Jiaxing, Li Heqi, Liu Kai
Summary: This article proposes a neural network based direct lift landing control method for carrier-based aircraft, aiming at optimizing the control parameters in the landing control phase. By introducing neural network into the direct force loop, the controller parameters are optimized online to improve the convergence speed. Simulation experiments with the interference of deck motion, carrier air wake, and Monte Carlo pull deviation condition are performed, and the results show that the trajectory correction speed of the ship-based aircraft direct lift landing control based on neural network is faster, with smaller overshoot and higher accuracy.
PROCEEDINGS OF 2022 INTERNATIONAL CONFERENCE ON AUTONOMOUS UNMANNED SYSTEMS, ICAUS 2022
(2023)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.