Article
Anesthesiology
Yang Ren, Yinhui Zhou, Zerong You, Hao Deng, William R. Kem, Jianren Mao, Wei Zhang, J. A. Jeevendra Martyn
Summary: This study found that morphine exacerbates burn injury-site pain and microglia activation, while GTS-21 alleviates morphine-induced pain and microglia activation in burn injury.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Neurosciences
Donghai Li, Tianpeng He, Yue Zhang, Junru Liu, Haiyu Zhao, Dongliang Wang, Quanchao Wang, Shengxiang Zhang, Yuan Yuan
Summary: Ischemic stroke is a major cause of death and disability globally, with neuroinflammation playing a key role in its development. Microglia, the primary immune cells in the brain, undergo rapid activation and polarization following ischemic stroke, which is crucial in regulating the inflammatory response. Melatonin, a promising neuroprotective agent, can regulate microglial polarization in central nervous system diseases, but its specific mechanism in protecting against ischemic stroke-induced brain injury remains unclear.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Enkhmurun Chibaatar, Kai Le, Idriss Ali Abdoulaye, Shanshan Wu, Yijing Guo
Summary: The study demonstrated that melatonin suppressed LPS-triggered inflammation mediated by BV2 microglial activation by inhibiting the high expression and release of HMGB1 and moderating the activation of the TLR4/MyD88/NF-kappa B signaling pathway. Additionally, pre-treatment with melatonin notably reversed the LPS-induced expression of pro-inflammatory cytokines.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Ling-Yan Su, Qianjin Liu, Lijin Jiao, Yong-Gang Yao
Summary: Drug addiction presents a global health issue with significant financial implications. Chronic morphine use leads to tolerance, hyperalgesia, and addiction, limiting its clinical utility. Studies have shown that combining melatonin with morphine can reverse the affected pathways, improving morphine-induced tolerance and addictive behaviors.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemical Research Methods
Ana Baamonde, Luis Menendez
Summary: Pharmacological assays based on nociceptive responses help assess analgesic strategies, but interpretation and relevance can be challenging. This discussion-based manuscript addresses central issues that often arise in pain research, including the influence of behavioral methods, acceptance of data obtained with standard versus alternative methods, and the complexities of molecules with dual effects.
JOURNAL OF NEUROSCIENCE METHODS
(2023)
Article
Biochemistry & Molecular Biology
Elham Charmchi, Golnaz Faramarzi, Mina Rashvand, Morteza Zendehdel, Abbas Haghparast
Summary: Injecting D1/D2-like dopamine receptor antagonists directly into the NAc of rats can block the sensitization of morphine antinociceptive effects induced by restraint stress. This indicates the crucial role of accumbal dopamine receptors in morphine sensitization caused by co-administration of stress and morphine.
NEUROCHEMICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Haiyan Wang, Min Huang, Wenying Wang, Yu Zhang, Xiaqing Ma, Limin Luo, Xiaotao Xu, Liang Xu, Haibo Shi, Yongming Xu, Aizhong Wang, Tao Xu
Summary: The study revealed that microglial TLR4 regulates TAK1 expression and phosphorylation, leading to NLRP3 activation that contributes to neuroinflammation and the development of morphine tolerance. Targeting TLR4-TAK1-NLRP3 signaling may offer alternative therapeutic strategies for chronic morphine-induced antinociceptive tolerance.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Toxicology
Sen Guan, Fan Miao, Dongmei Wang, Jie Hu, Huimiao Wang
Summary: This study aimed to investigate the effects of Corilagin (Cori) on morphine-induced neuroinflammation and microglia activation, and to explore the underlying mechanism through TLR2-mediated endoplasmic reticulum stress (ERS) inhibition. The results showed that Cori effectively alleviated morphine-induced neuroinflammation and microglia activation in BV-2 cells by reducing the expression of IBA-1, proinflammatory cytokines, NLRP3 inflammasome, and ERS. Molecular docking investigation confirmed the high affinity between Cori and TLR2 protein. Therefore, Cori may serve as a potential drug to overcome morphine tolerance.
JOURNAL OF TOXICOLOGICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Sajad Mazaheri, Morteza Zendehdel, Abbas Haghparast
Summary: The study investigated the role of orexin receptors in the ventral tegmental area (VTA) in stress-induced morphine sensitization. The results showed that concurrent exposure to stress and morphine can induce morphine sensitization, and administration of orexin receptor antagonists can block this effect. This study provides new insights into the role of orexin signaling in the VTA in the potentiation of morphine sensitization induced by stress and morphine co-administration.
Article
Chemistry, Medicinal
E. A. Ivanova, T. A. Voronina, N. V. Korobov, V. S. Kosorukov
Summary: The tetrapeptide H-Tyr-D-Arg-Phe-Gly-NH2 (Taphalgin) was found to significantly prolong the tail-flick latency in mice within the dose range of 0.01-5 mg/kg. The analgesic effect of a single injection of Taphalgin at 1 mg/kg surpasses that of morphine hydrochloride at the same dose. The magnitude and duration of the analgesic effect of Taphalgin increase as the dose is raised from 0.5 to 1.5 and 4.5 mg/kg, with the maximum duration observed at 1.5 and 4.5 mg/kg.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2022)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.
