Journal
LIFE SCIENCES
Volume 167, Issue -, Pages 22-31Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2016.10.019
Keywords
Fat body remodeling; Fat mobilization; Energy storage; Lipometabolism; Drosophila
Funding
- National Basic Research Program of China (973 Program) [2012CB966804]
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Remarkable advances have been made in recent years in our understanding of the Drosophila fat body and its functions in energy storage, immune response and nutrient sensing. The fat body interplays with other tissues to respond to the physiological needs of the body's growth and coordinates various metabolic processes at different developmental stages and under different environmental conditions. The identification of various conserved genetic functions and signaling pathways relating to the Drosophila fat body may provide clues to lipometabolic disease and other aspects of tissue remodeling in humans. Here, we discuss recent insights into how regulation of fat body remodeling contributes to hemostasis with a special focus on how signaling networks and internal physiological states shape different aspects of the lipid metabolism in Drosophila. (C) 2016 Published by Elsevier Inc.
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