The NEDD8-activating enzyme inhibitor pevonedistat activates the eIF2α and mTOR pathways inducing UPR-mediated cell death in acute lymphoblastic leukemia
The NEDD8-activating enzyme inhibitor pevonedistat activates the eIF2α and mTOR pathways inducing UPR-mediated cell death in acute lymphoblastic leukemia
Authors
Keywords
Leukemia, NEDD8 conjugation pathway, Pevonedistat, Protein translation, ER stress/UPR, MEK/ERK, NSG mice, Combination targeted therapy
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