☆ 4.2 Article

Synthesis and Chemical Structure Elucidation of Two Schiff Base Ligands, Their Iron(II) and Zinc(II) Complexes, and Antiradical, Antimicrobial, Antioxidant Properties

LETTERS IN ORGANIC CHEMISTRY (2016)

Journal

LETTERS IN ORGANIC CHEMISTRY

Volume 13, Issue 5, Pages 343-351

Publisher

BENTHAM SCIENCE PUBL LTD

DOI: 10.2174/1570178613666160422161855

Keywords

Antimicrobials; antioxidants; antiradicals; Thermal studies; Zn(II) and Fe(II) complexes; Schiff bases

Categories

Chemistry, Organic

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Abstract

Fe(II) and Zn(II) complex series have been synthesized from Schiff base ligands derived from furan-2-carbaldehyde and thiophene-2-carbaldehyde. Elemental, infrared, ultra-violet- visible, NMR and thermal analysis, also mass spectroscopy and magnetic susceptibility measurements were performed to explain the structures of these synthesized ligands and their metal complexes. The formulas based on analytical, spectral, and magnetic studies, the complexes can be demonstrated as [M(L-1)(2)](H2O)(n), [M(L-2)(2)](H2O)(n), where M = Zn(II) and Fe(II). An octahedral geometry was suggested for the Zn(II) and Fe(II) complexes. The antioxidant, antiradical and antimicrobial properties of the Zn(II) and Fe(II) complexes were investigated using different in vitro assays. Some of the complexes showed reasonable amount of antioxidant and antimicrobial activity.

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.2

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Chemistry, Inorganic & Nuclear

Synthesis, characterization, DFT and biological studies of Fe(II), Cu(II), and Zn(II) complexes of keto-imine chelators

Festus Chioma, Chizoba I. Ezugwu, Obinna Okpareke

Summary: Synthesis of chelators and their complexes with metal ions enhances antimicrobial and antifungal activities, while exhibiting good antioxidant abilities.

INORGANICA CHIMICA ACTA (2023)

Add to Collection

Article Thermodynamics

Green synthesis of a Schiff base ligand and its Co(II), Cu(II) and Zn(II) complexes: thermoanalytical and spectroscopic studies

Aniele de Moura, Jose Benedito Junior, Ana Carina Sobral Carvalho, Flavio Junior Caires

Summary: Schiff bases are organic compounds with broad biological activity and potential applications. This study focused on the synthesis of a Schiff base derived from 4-aminosalicylic acid and salicylaldehyde, as well as its metal complexes, using eco-friendly methods. Spectroscopic and thermal analysis techniques were used to characterize their structures and thermal behavior.

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY (2022)

Add to Collection

Article Chemistry, Physical

Synthesis, characterization and pharmacological studies of cobalt(II), nickel (II) and copper (II) complexes of thiazole schiff bases

Bhushan S. Sail, Vinod H. Naik, B. M. Prasanna, Naushad Ahmad, Mohammad Rizwan Khan, M. R. Jagadeesh, Ravikumar Cheedarala

Summary: Many Schiff bases derived from 2-hydrazinobenzothiazole and isatin have been used to form [ML2]Cl2 type Co(II) complexes. Nitrogen from azomethine, oxygen from lactonyl, and nitrogen atoms of the thiazole ring contribute to coordinating the metallic ion. The complexes consist entirely of metal and have a geometrical octahedron structure, as confirmed by analytical, magnetic, and spectroscopic investigations.

JOURNAL OF MOLECULAR STRUCTURE (2023)

Add to Collection

Article Infectious Diseases

A Review on the Antimicrobial Activity of Schiff Bases: Data Collection and Recent Studies

Jessica Ceramella, Domenico Iacopetta, Alessia Catalano, Francesca Cirillo, Rosamaria Lappano, Maria Stefania Sinicropi

Summary: Schiff bases have a wide range of applications in various fields and their conjugation with chitosan can enhance chitosan's antibacterial activity. The use of Schiff base nanoparticles can also improve their antimicrobial effects.

ANTIBIOTICS-BASEL (2022)

Add to Collection

Article Chemistry, Physical

Synthesis of new Schiff base and its Ni(II), Cu(II), Zn(II) and Co(II) complexes; photophysical, fluorescence quenching and thermal studies

Gulnur Keser Karaoglan

Summary: In this study, a new series of Schiff base metal complexes were synthesized and characterized. The thermal stability and photophysical properties of these complexes were investigated. The results showed that the metal ions affected the thermal strength and fluorescence quenching constant of the complexes, with the Cu(II) complex exhibiting the highest thermal strength. Due to their high fluorescence quenching constants, these complexes could be potential active ingredients in anticancer drug transport systems.

JOURNAL OF MOLECULAR STRUCTURE (2022)

Add to Collection

Article Chemistry, Physical

Synthesis, electrochemical, and quantum chemical studies of some metal complexes: Mn(II), Co(II), and Zn(II) with 2-furaldehyde semicarbazone

Cherifa Boulechfar, Hana Ferkous, Sihem Boufas, Malika Berredjem, Amel Delimi, Souad Djellali, Amel Djedouani, Rania Bahadi, Sihem Laamari, Krishna Kumar Yadav, Byong-Hun Jeon, Wahiba Bouchelaghem, Manawwer Alam, Yacine Benguerba

Summary: In this study, experimental and computational investigations were conducted on a Schiff base and its metal complexes. The azote atom coordinates with the metal according to the FT-IR spectra. Powder X-ray Diffraction experiments show that the crystalline nature of metal complexes is responsible for their enhanced crystallinity. X-ray photoelectron spectroscopy shows that the binding energy of the nitrogen atom's 1s electrons is increased in metal complexes due to complexation. Cyclic voltammograms and DPPH radical scavenging assay demonstrate that transition metal complexes are more effective at scavenging DPPH radicals compared to the free ligand. The theoretical analysis of the investigated complexes provides evidence of the metal's bonding potential in the environment.

JOURNAL OF MOLECULAR STRUCTURE (2023)

Add to Collection

Article Chemistry, Physical

Structural characterization and molecular docking studies of biologically active platinum(II) and palladium(II) complexes of ferrocenyl Schiff bases

Fatma N. Sayed, Gehad G. Mohamed, Reem G. Deghadi

Summary: Four new Pt(II)/Pd(II) complexes were synthesized and their structures were confirmed using spectroscopic techniques. The synthesized complexes showed good antibacterial and cytotoxic activities, which were further validated by molecular docking studies with protein receptors.

JOURNAL OF MOLECULAR STRUCTURE (2023)

Add to Collection

Article Chemistry, Physical

Synthesis, characterization, and biological activity of Co(II) and Zn(II) complexes of imidazoles-based azo-functionalized Schiff bases

Ahmed R. E. Mahdy, Ola A. Abu Ali, Waleed M. Serag, Eman Fayad, Reda F. M. Elshaarawy, Emad M. Gad

Summary: A series of azo-functionalized Schiff base ligands containing different imidazole derivatives and their Co(II)/Zn(II) complexes were synthesized and characterized. The metal complexes exhibited higher thermal stability and showed inhibitory activity against breast carcinoma cells. The most potent and selective anti-breast cancer agent was found to be CoL3.

JOURNAL OF MOLECULAR STRUCTURE (2022)

Add to Collection

Article Thermodynamics

Green synthesis of niflumic acid complexes with some transition metal ions (Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II)). Spectroscopic, thermoanalytical and antibacterial studies

Lidia Zapala, Malgorzata Kosinska-Pezda, Lukasz Byczynski, Wojciech Zapala, Urszula Maciolek, Elzbieta Woznicka, Ewa Ciszkowicz, Katarzyna Lecka-Szlachta

Summary: New complexes of Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) ions with niflumic acid (Hnif) were synthesized using a green method and their physico-chemical properties, thermoanalytical behavior and antibacterial activity were investigated. The compounds were found to undergo multi-stage thermal decomposition, with the dehydration process occurring in two steps. The complex with Zn(II) ions displayed the most effective antibacterial activity against E. coli and P. aeruginosa.

THERMOCHIMICA ACTA (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Green light emitting fluorescent [Zn(II)(Schiff base)] complexes as electroluminescent material in organic light emitting diodes

P. H. Amith Nayak, H. S. Bhojya Naik, R. Viswanath, B. R. Kirthan

Summary: The study developed efficient light-emissive materials for organic light-emitting diodes, with zinc metal complexes showing promising results as emissive layers emitting green and yellowish-orange colors. This research indicates the potential of these zinc complexes as strong electroluminescent materials for opto-electronic applications.

JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS (2021)

Add to Collection

Article Chemistry, Inorganic & Nuclear

Synthesis, physicochemical properties, biological, molecular docking and DFT investigation of Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) complexes of the 4-[(5-oxo-4,5-dihydro-1,3-thiazol-2-yl)hydrazono]methyl}phenyl 4-methylbenzenesulfonate Schiff-base ligand

Nadia A. A. Elkanzi, Hajer Hrichi, Hanan Salah, Mha Albqmi, Ali M. Ali, Aly Abdou

Summary: A new Schiff-base ligand and its metal complexes with Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) were synthesized and characterized. The metal complexes exhibited either a tetrahedral or octahedral structure. In addition to their antibacterial and antifungal efficacy, the metal complexes also showed higher antioxidant activity compared to the free ligand.

POLYHEDRON (2023)

Add to Collection

Article Chemistry, Physical

Synthesis, structural elucidation, Hirshfeld surface analysis and cytotoxicity studies of homometallic dinuclear Cu(II), Ni(II) and Zn(II) Schiff base complexes derived from m-phenylenediamine

Siti Solihah Khaidir, Shahrul Nizam Ahmad, Karimah Kassim, Siti Syaida Sirat, Kalavathy Ramasamy, Bohari M. Yamin, Kong Wai Tan, Hadariah Bahron

Summary: A polydentate Schiff base ligand has been synthesized, and its Cu(II), Ni(II), and Zn(II) complexes have been prepared and characterized. The Cu(II) complex showed significant cytotoxic activity against colon cancer cells.

JOURNAL OF MOLECULAR STRUCTURE (2023)

Add to Collection

Review Chemistry, Inorganic & Nuclear

Metal Complexes with Schiff Bases as Antimicrobials and Catalysts

Domenico Iacopetta, Jessica Ceramella, Alessia Catalano, Annaluisa Mariconda, Federica Giuzio, Carmela Saturnino, Pasquale Longo, Maria Stefania Sinicropi

Summary: Complexes of Schiff bases with metals are versatile compounds with a wide range of applications, including catalysis, polymers, dyes, and various biological activities, such as antimicrobial, anticancer, antioxidant, antimalarial, analgesic, antiviral, antipyretic, and antidiabetic actions. In this review, the focus is on the antimicrobial activity of Schiff bases, especially the most recent studies in this field. Moreover, some interesting catalytic applications of metal complexes with Schiff bases are also discussed.

INORGANICS (2023)

Add to Collection

Article Chemistry, Physical

Corrosion inhibition of Schiff base and their metal complexes with [Mn (II), Co (II) and Zn (II)]: Experimental and quantum chemical studies

Cherifa Boulechfar, Hana Ferkous, Amel Delimi, Malika Berredjem, Abdesalem Kahlouche, Anis Madaci, Souad Djellali, Sihem Boufas, Amel Djedouani, Abdelhamid Errachid, Azmat Ali Khan, Abir Boublia, Tarek Lemaoui, Yacine Benguerba

Summary: In this study, the synthesis, characterization, and anti-corrosion performance of 2-furaldehyde semi-carbazone Schiff base (FSC) complexes of cobalt (II), zinc (II), and manganese (II) on XC38 carbon steel immersed in 1 M HCl solution were investigated. Experimental investigations and quantum chemical simulation approaches were used. The results showed that these compounds are powerful inhibitors with significant adsorption on the steel surface, providing considerable inhibition. SEM analysis revealed that FSC and its complexes formed a barrier between the inhibitors and the vacant d-orbital of iron on the XC38 carbon steel surface.

JOURNAL OF MOLECULAR LIQUIDS (2023)

Add to Collection

Article Chemistry, Applied

Synthesis, characterization, molecular docking, biological activity, and DNA cleavage studies of Cu(II), Co(II), Ni(II), Mn(II), and Cd(II) Schiff base complexes

Adel Z. El-Sonbati, Mostafa A. Diab, Ahmed K. El-Sayed, Mohamed Abou-Dobara, Sameh A. El-Sayad

Summary: Metal complexes of a Schiff base ligand derived from 2,4-dihydroxybenzaldehyde and p-nitroaniline were synthesized and characterized. The complexes showed antibacterial, antifungal, and cytotoxic activities, and the ligand exhibited high binding affinity to various receptors.

APPLIED ORGANOMETALLIC CHEMISTRY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Synthesis, characterization, antiproliferative of pyrimidine based ligand and its Ni(II) and Pd(II) complexes and effectiveness of electroporation

Mehmet Esref Alkis, Kenan Buldurun, Nevin Turan, Yusuf Alan, Unzile Kelestemur Yilmaz, Asim Mantarci

Summary: In this study, a new Schiff base and its Ni(II) and Pd(II) complexes were synthesized and characterized. The antiproliferative activities of these compounds on liver cancer cells were evaluated, and it was found that the complexes exhibited stronger activity than the ligand. Electroporation was also shown to enhance the cytotoxicity of the complexes. These findings suggest that the Ni(II) and Pd(II) complexes have potential as anti-cancer agents, particularly in electrochemotherapy.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2022)

Add to Collection

Article Chemistry, Physical

Synthesis and in silico studies of Novel Ru(II) complexes of Schiff base derivatives of 3-[(4-amino-5-thioxo-1,2,4-triazole-3-yl)methyl]-2(3H)-benzoxazolone compounds as potent Glutathione S-transferase and Cholinesterases Inhibitor

Ragip Adiguzel, Fikret Turkan, Umit Yildiko, Abdulmelik Aras, Enes Evren, Tijen Onkol

Summary: Novel Ru(II) complexes of Shiff base derivatives were synthesized and their structures confirmed. The inhibitory potency of the complexes against various enzymes was evaluated, showing significant inhibitory activity with promising Ki values. The compounds were observed to bind in the active site of the enzymes with similar binding orientation and interactions.

JOURNAL OF MOLECULAR STRUCTURE (2021)

Add to Collection

Article Chemistry, Inorganic & Nuclear

Preparation, spectral characterization, ESR measurements and DFT calculations of Schiff base copper(II) complex

Sibel Tokdemir Ozturk, Perihan Aksu, Nevin Turan, Kenan Buldurun, Emine Tanis, Naki Colak

Summary: The synthesized copper(II) complex was confirmed using various techniques, with DFT calculations and NBO analysis providing insights into its vibrational and electronic properties. The results of the study indicate that the synthesis was successful and the compound possesses reasonable properties.

INORGANIC AND NANO-METAL CHEMISTRY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Some metal chelates with Schiff base ligand: synthesis, structure elucidation, thermal behavior, XRD evaluation, antioxidant activity, enzyme inhibition, and molecular docking studies

Nevin Turan, Kenan Buldurun, Fikret Turkan, Abdulmelik Aras, Naki Colak, Manikanta Murahari, Ercan Bursal, Asim Mantarci

Summary: Schiff bases are known for their significant biological properties. A new Schiff base ligand and its metal complexes were synthesized in this study, and their antioxidant and enzyme inhibitory activities were evaluated. The Schiff base ligand showed better antioxidant properties compared to its metal complexes, and it exhibited the best inhibition for AChE and BChE enzymes.

MOLECULAR DIVERSITY (2022)

Add to Collection

Article Chemistry, Inorganic & Nuclear

Pd(II)-Schiff base complexes: Synthesis, characterization, Suzuki-Miyaura and Mizoroki-Heck cross-coupling reactions, enzyme inhibition and antioxidant activities

Nevin Turan, Kenan Buldurun, Ercan Bursal, Ghodrat Mahmoudi

Summary: In this study, new coordination complexes of Pd(II) with Schiff base ligands were synthesized and characterized. The complexes showed promising catalytic activity, particularly 1b and 1c, which exhibited high selectivity in conversions with high conversion rates. The complexes, especially 1a and 1e, also demonstrated effective antioxidant activity.

JOURNAL OF ORGANOMETALLIC CHEMISTRY (2022)

Add to Collection

Article Chemistry, Physical

Half-sandwich ruthenium(II)(η6-p-cymene) complexes: Syntheses, characterization, transfer hydrogenation reactions, antioxidant and enzyme inhibitory activities

Kenan Buldurun, Nevin Turan, Ghodrat Mahmoudi, Ercan Bursal

Summary: Five new Ru(II)(η(6)-p-cymene) complexes were synthesized and characterized. They were found to have effective inhibitions against enzymes and strong antioxidant potentials.

JOURNAL OF MOLECULAR STRUCTURE (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Synthesis and Characterization of Azo Dye Complexes as Potential Inhibitors of Acetylcholinesterase, Butyrylcholinesterase, and Glutathione S-Transferase

Kenan Buldurun, Abdulmelik Aras, Nevin Turan, Fikret Turkan, Ragip Adiguzel, Ercan Bursal

Summary: Metal complexes of an azo dye ligand (ADL) were synthesized, characterized, and evaluated for their biological activities. The Co(II) complex exhibited the most effective enzyme inhibition against GST, AChE, and BChE enzymes, indicating its potential as a pharmaceutical agent.

CHEMISTRYSELECT (2022)

Add to Collection

Article Chemistry, Physical

Synthesis, Structural Characterization of Schiff Base Ligands and Their RuII-p-Cymene Complexes, and Catalytic Activity in the Transfer Hydrogenation of Ketones

Nevin Turan, Abbas Akdeniz

Summary: In this study, two new Schiff base ligands and their corresponding RuII complexes were synthesized and characterized. The obtained RuII complexes showed good catalytic activity in transfer hydrogen reactions. The structures of the compounds were elucidated using various analytical techniques.

CATALYSIS LETTERS (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Electroporation Enhances the Anticancer Effects of Novel Cu(II) and Fe(II) Complexes in Chemotherapy-Resistant Glioblastoma Cancer Cells

Mehmet Esref Alkis, Kenan Buldurun, Yusuf Alan, Nevin Turan, Ayhan Altun

Summary: The Schiff base ligand (L) was synthesized and used for complexation with Cu(II) and Fe(II) ions. The structural features of the ligand and metal complexes were determined by various spectroscopic methods. The synthesized compounds showed good anti-proliferative effects on U118 and T98G glioblastoma cell lines and negligible cytotoxicity on human dermal fibroblast (HDF) cell lines. The use of compounds in combination with electroporation (EP) resulted in significantly decreased IC50 values.

CHEMISTRY & BIODIVERSITY (2023)

Add to Collection

Article Chemistry, Physical

Synthesis of Pd +2 complexes of Schiff bases containing methyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate and spectral and catalytic activities

Kenan Buldurun, Tayfun Saridag

Summary: In this study, ONS-donor atom containing Schiff base ligands (1, 2) were utilized to synthesize complexes 1a and 2a. The ligands were prepared using 2-hydroxy-3-methoxybenzaldehyde and 4-benzoxybenzaldehyde with a precursor in an ethanol medium. Pd(II) complexes (1a, 2a) were then formed by reacting the corresponding [PdCl2(CH3CN)2] with the Schiff base ligands in a 1:1 molar proportion. The molecular structures of the Schiff bases (1, 2) and their Pd(II) complexes (1a, 2a) were characterized using various analytical/spectroscopic techniques. The results demonstrated that the presence of complexes 1a and 2a as catalysts could facilitate Suzuki-Miyaura and Mizoroki-Heck cross-coupling reactions, leading to high-yield coupling products.

JOURNAL OF MOLECULAR STRUCTURE (2023)

Add to Collection

Article Chemistry, Physical

Synthesis, characterization, Suzuki-Miyaura and Mizoroki-Heck cross-coupling reactions of Schiff base-Pd(II) complexes

Abbas Akdeniz, Nevin Turan

Summary: Cross-coupling reactions are powerful tools for carbon-carbon bond formation in organic synthesis. Palladium-catalyzed cross-coupling reactions have attracted significant attention. Two new Schiff base-Pd(II) complexes were synthesized and characterized. The complexes were applied in Suzuki-Miyaura and Mizoroki-Heck cross-coupling reactions, showing high yields. Electron-donating and electron-withdrawing substituents on aryl halides can produce coupling products in perfect yield in the presence of these complexes.

JOURNAL OF MOLECULAR STRUCTURE (2023)

Add to Collection

Article Thermodynamics

Preparation of composite supported phase change materials from inorganic-based microcapsules of cetyl alcohol and investigation of their phase change material (PCM) behaviors

Serap Karabulut, Memet Sekerci, Ragip Adiguzel, Zuhal Karagoz Genc

Summary: In this study, cetyl alcohol was microencapsulated with titanium-n-butoxide using the coacervation method. The thermal and structural analyses confirmed that cetyl alcohol has phase change material properties. Microencapsulated samples were prepared by adding barite, boron nitride, marble powder, and fly ash. The structural and thermal properties of the microencapsulated PCM and composite-supported microencapsulated PCMs were analyzed using FTIR, DSC, TGA, and SEM devices. The results showed that barite and boron nitride microencapsulated samples exhibited the most suitable structural and thermal properties for thermal energy storage in buildings.

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY (2023)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.