Journal
FRONTIERS IN ONCOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2023.1149450
Keywords
diffuse large B cell lymphoma; inflammatory bowel disease (IBD); tisagenlecleucel; case report; CAR T cells
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We report a case of a 70-year-old female patient with diffuse large B cell lymphoma (DLBCL) treated with tisagenlecleucel, who developed chronic diarrhea with inflammatory bowel disease (IBD)-like colitis. CAR T cells were found to be enriched in the colon lamina propria and other diagnoses were ruled out. Therefore, we conclude that IBD-like colitis in this patient was associated with CAR T cell therapy and should be considered as a rare potential complication.
Chimeric antigen receptor (CAR) T cell therapy has become a new mainstay in the treatment of several hematologic malignancies, but the spectrum of associated complications is still incompletely defined. Here, we report the case of a 70-year-old female patient treated with tisagenlecleucel for diffuse large B cell lymphoma (DLBCL), who developed chronic diarrhea with characteristics of inflammatory bowel disease (IBD)-like colitis. CAR T cells were substantially enriched in the colon lamina propria and other diagnoses were ruled out. Thus, we conclude that IBD-like colitis in this patient was associated to CAR T cell therapy and needs to be considered as a rare potential complication.
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