Dual Targeting of EGFR and MTOR Pathways Inhibits Glioblastoma Growth by Modulating the Tumor Microenvironment

Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias

(2022) Chun Hu et al.   NATURE

Targeting the EGF receptor family in non-small cell lung cancer—increased complexity and future perspectives

(2022) Tobias Boch et al.   Cancer Biology & Medicine

BPTF promotes the progression of distinct subtypes of breast cancer and is a therapeutic target

(2022) Vladimir Bezrookove et al.   Frontiers in Oncology

Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance

(2021) Wei Wu et al.   PHARMACOLOGICAL RESEARCH

The Role of EREG/EGFR Pathway in Tumor Progression

(2021) Wan-Li Cheng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Immunotherapy Resistance in Glioblastoma

(2021) Elaina J. Wang et al.   Frontiers in Genetics

Therapeutic strategies of glioblastoma (GBM): The current advances in the molecular targets and bioactive small molecule compounds

(2021) Hui Liu et al.   Acta Pharmaceutica Sinica B

Drug Resistance in Glioma Cells Induced by a Mesenchymal–Amoeboid Migratory Switch

(2021) Sophie E. Ketchen et al.   Biomedicines

Glioblastoma in Adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) Consensus Review on Current Management and Future Directions

(2020) Patrick Y Wen et al.   NEURO-ONCOLOGY

Longer-term (≥ 2 years) survival in patients with glioblastoma in population-based studies pre- and post-2005: a systematic review and meta-analysis

(2020) Michael T. C. Poon et al.   Scientific Reports

Innovative Therapeutic Strategies for Effective Treatment of Brain Metastases

(2019) Malcolm Lim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The TICking clock of EGFR therapy resistance in glioblastoma: Target Independence or target Compensation

(2019) Hamza Saleem et al.   DRUG RESISTANCE UPDATES

Tissues Harvested Using an Automated Surgical Approach Confirm Molecular Heterogeneity of Glioblastoma and Enhance Specimen's Translational Research Value

(2019) Edie Zusman et al.   Frontiers in Oncology

Drug responses are conserved across patient-derived xenograft models of melanoma leading to identification of novel drug combination therapies

(2019) Ryan J. Ice et al.   BRITISH JOURNAL OF CANCER

Activation of the Receptor Tyrosine Kinase AXL Regulates the Immune Microenvironment in Glioblastoma

(2018) Hirokazu Sadahiro et al.   CANCER RESEARCH

Immune Microenvironment in Glioblastoma Subtypes

(2018) Zhihong Chen et al.   Frontiers in Immunology

Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy

(2018) Jin-Ku Lee et al.   NATURE GENETICS

EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma

(2018) Zhenyi An et al.   CANCER RESEARCH

Targeting mTOR in Glioblastoma: Rationale and Preclinical/Clinical Evidence

(2018) Carmen Mecca et al.   DISEASE MARKERS

EGFR heterogeneity and implications for therapeutic intervention in glioblastoma

(2017) Eskil Eskilsson et al.   NEURO-ONCOLOGY

Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma

(2017) Spyros Darmanis et al.   Cell Reports

The role of microglia and macrophages in glioma maintenance and progression

(2016) Dolores Hambardzumyan et al.   NATURE NEUROSCIENCE

In search of a target: PD-1 and PD-L1 profiling across glioma types

(2016) Anna S. Berghoff et al.   NEURO-ONCOLOGY

Cytomegalovirus Immediate-Early Proteins Promote Stemness Properties in Glioblastoma

(2015) L. Soroceanu et al.   CANCER RESEARCH

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

(2015) Wenchao Zhou et al.   NATURE CELL BIOLOGY

Reactive oxygen species-mediated therapeutic response and resistance in glioblastoma

(2015) E Singer et al.   Cell Death & Disease

A single-institution phase II trial of radiation, temozolomide, erlotinib, and bevacizumab for initial treatment of glioblastoma

(2014) J. L. Clarke et al.   NEURO-ONCOLOGY

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Treatment Options in Newly Diagnosed Glioblastoma

(2013) Eudocia Q. Lee et al.   Current Treatment Options in Neurology

Efficacy of erlotinib in patients with relapsed gliobastoma multiforme who expressed EGFRVIII and PTEN determined by immunohistochemistry

(2013) Oscar Gallego et al.   JOURNAL OF NEURO-ONCOLOGY

Erlotinib resistance in EGFR-amplified glioblastoma cells is associated with upregulation of EGFRvIII and PI3Kp110 

(2013) A. Schulte et al.   NEURO-ONCOLOGY

YKL-40 acts as an angiogenic factor to promote tumor angiogenesis

(2013) Rong Shao   Frontiers in Physiology

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Safety and efficacy of erlotinib in first-relapse glioblastoma: a phase II open-label study

(2010) W. K. A. Yung et al.   NEURO-ONCOLOGY

mTOR signaling in glioblastoma: lessons learned from bench to bedside

(2010) D. Akhavan et al.   NEURO-ONCOLOGY

Glioblastoma Subclasses Can Be Defined by Activity among Signal Transduction Pathways and Associated Genomic Alterations

(2009) Cameron Brennan et al.   PLoS One

Platelet-derived growth factor-α receptor activation is required for human cytomegalovirus infection

(2008) Liliana Soroceanu et al.   NATURE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE