Journal
REDOX BIOLOGY
Volume 62, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.redox.2023.102659
Keywords
Reactive oxygen species; Oxidative stress; Ovarian diseases; Antioxidant drugs; Hormones; Mesenchymal stem cells
Categories
Ask authors/readers for more resources
Reactive oxygen species (ROS) are produced in mitochondria and play a crucial role in regulating the ovarian cycle through signaling. However, an imbalance between ROS generation and the antioxidant defense system can lead to ovarian diseases. Understanding the mechanisms of ROS generation and homeostasis in the ovary, as well as the pathological effects and potential antioxidant strategies, is important for the development of effective treatments.
Reactive oxygen species (ROS) are mainly produced in mitochondria and are involved in various physiological activities of the ovary through signaling and are critical for regulating the ovarian cycle. Notably, the imbalance between ROS generation and the antioxidant defense system contributes to the development of ovarian diseases. These contradictory effects have critical implications for potential antioxidant strategies that aim to scavenge excessive ROS. However, much remains to be learned about how ROS causes various ovarian diseases to the application of antioxidant therapy for ovarian diseases. Here, we review the mechanisms of ROS generation and maintenance of homeostasis in the ovary and its associated physiological effects. Additionally, we have highlighted the pathological mechanisms of ROS in ovarian diseases and potential antioxidant strategies for treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available