Article
Engineering, Multidisciplinary
Yan Li, Juan Wang, Yan Wang, Wenguo Cui
Summary: Hydrogel fibers, derived from the combination of hydrogel and electrospinning, have shown great potential in tissue regeneration and wound healing due to their structural properties and biological functions. Researchers have been particularly interested in the high specific surface area and mechanical advantages provided by these materials, making them promising for various biomedical applications.
COMPOSITES PART B-ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Yishu Yan, Panpan Ren, Qingqing Wu, Tianmeng Zhang
Summary: This study used microgel particles as crosslinkers to create alginate hydrogel with high tunability. The results showed that the hydrogel facilitated live-cell infiltration in vitro and boosted tissue regeneration of diabetic wounds in vivo.
Review
Chemistry, Multidisciplinary
Ruinan Hao, Zhuoyi Cui, Xindan Zhang, Ming Tian, Liqun Zhang, Feng Rao, Jiajia Xue
Summary: Skin wound healing is a dynamic and complex process, and effectively treating wounds and regenerating damaged skin is a clinical challenge. Hydrogels, through rational design and preparation, have the potential to play a significant role in skin wound healing. This mini review introduces the design and construction of hydrogels, summarizes the recent research progress on functional bioactive hydrogel dressings for skin wound healing, and highlights the design strategies of responsive hydrogels to physical stimuli. The review also provides perspectives on future directions and challenges of functional hydrogels for skin wound healing.
FRONTIERS IN CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Yongping Liang, Jiahui He, Baolin Guo
Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.
Article
Biotechnology & Applied Microbiology
Tian-Long Wang, Zi-Fei Zhou, Jun-Feng Liu, Xiao-Dong Hou, Zhi Zhou, Yun-Lu Dai, Zhi-Yong Hou, Feng Chen, Long-Po Zheng
Summary: The new CuNA hydrogel prepared in this study has excellent mechanical properties, biocompatibility, antibacterial ability, and bioactivity. It accelerates wound healing, inhibits inflammatory response, and promotes new blood vessel formation and deposition of collagen and elastic fibers in vivo models.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Engineering, Biomedical
Mohammad Hadi Norahan, Sara Cristina Pedroza-Gonz, Monica Gabriela Sanchez-Salazar, Mario Moises Alvarez, Grissel Trujillo de Santiago
Summary: Chronic wounds have become a major problem in healthcare systems, leading to death worldwide. Engineering wound dressings with hydrogels can significantly improve healing time, reduce infections, and lower costs. Hydrogels provide a protective barrier, mimic the extracellular matrix, and create a moist environment. Different fabrication methods and properties of hydrogels have been extensively studied for wound healing applications, including the use of additives to enhance tissue regeneration. Hydrogel engineering offers smart solutions for effective wound healing, with capabilities such as inhibiting bacterial growth, promoting re-epithelialization, and improving tissue functionality.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Physical
Bin Kong, Rui Liu, Yi Cheng, Xiaodong Cai, Junying Liu, Dagan Zhang, Hui Tan, Yuanjin Zhao
Summary: Developing a biocompatible and multifunctional adhesive hydrogel for wound healing is a highly anticipated clinical application. In this paper, a novel natural biopolymer-derived hydrogel based on aldehyde-modified oxidized guar gum (OGG) and carboxymethyl chitosan (CMCS) is presented. The hydrogel has excellent self-healing ability and shear thinning behavior, and can be injected conveniently through a needle. The physiochemical properties of the hydrogel can be controlled by regulating the concentrations of OGG. In addition, the hydrogel can adhere tightly to tissues and promote wound repair by encapsulating vascular endothelial growth factor (VEGF).
Article
Chemistry, Physical
Bin Kong, Rui Liu, Yi Cheng, Xiaodong Cai, Junying Liu, Dagan Zhang, Hui Tan, Yuanjin Zhao
Summary: This paper presents a biocompatible and multifunctional adhesive hydrogel based on oxidized guar gum and carboxymethyl chitosan for promoting wound healing. The hydrogel has self-healing ability and shear thinning behavior, allowing it to be easily injected. Its physiochemical properties can be controlled by regulating the concentrations of the hydrogel components. Additionally, the hydrogel exhibits strong adhesion to tissues at physiological temperature.
Article
Biochemistry & Molecular Biology
Zhicong Lin, Donghao Fan, Guojiao Li, Liming He, Xianyan Qin, Bin Zhao, Qin Wang, Wenlang Liang
Summary: This study developed a hydrogel with tissue adhesivity, conductivity, and antibacterial function, which showed promising results in promoting diabetic wound healing.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Jiayi Mao, Lu Chen, Zhengwei Cai, Shutong Qian, Zhimo Liu, Binfan Zhao, Yuguang Zhang, Xiaoming Sun, Wenguo Cui
Summary: The review discusses the use of macrophage immunotherapy in promoting wound healing, as well as the importance of biomaterials in regulating macrophage signaling for tissue regeneration.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Mairobi Persinal-Medina, Sara Llames, Manuel Chacon, Natalia Vazquez, Marta Pevida, Ignacio Alcalde, Sergio Alonso-Alonso, Laura Maria Martinez-Lopez, Jesus Merayo-Lloves, Alvaro Meana
Summary: This study developed a polymerizable skin hydrogel consisting of keratinocytes and fibroblast within a fibrin scaffold. The results showed that this hydrogel can effectively regenerate skin wounds, shortening the time needed for transplantation compared to other skin models. It is suggested that this polymerizable skin hydrogel is an inexpensive, easy and rapid treatment for improving the treatment of skin wounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Siming Zhang, Gaoran Ge, Yi Qin, Wenhao Li, Jiale Dong, Jiawei Mei, Ruixiang Ma, Xianzuo Zhang, Jiaxiang Bai, Chen Zhu, Weiwei Zhang, Dechun Geng
Summary: Poor wound healing after diabetes mellitus is characterized by persistent bleeding, inflammation dysregulation, blocked cell proliferation, infection susceptibility, and impaired tissue remodeling. Conventional wound dressings have limited functionality and fail to meet the requirements of diabetic wound healing. Stimuli-responsive hydrogels, which can change their properties in response to various stimuli, have shown promise in improving therapeutic efficacy and reducing toxicity for diabetic wound healing.
MATERIALS TODAY BIO
(2023)
Review
Biochemistry & Molecular Biology
Jason Llaneras, Caitlyn C. Belza, Samuel Eisenstein, Marek K. Dobke
Summary: Senescent cells and fibrosis impact the regenerative capacity of skin, particularly in chronic non-healing wounds. This study explores potential senescence reversing techniques and proposes the use of exosomes loaded with senolytics for improving chronic wound healing.
Article
Polymer Science
Karen Zulema Meza-Valle, Rosa Alicia Saucedo-Acuna, Karla Lizzette Tovar-Carrillo, Juan Carlos Cuevas-Gonzalez, Erasto Armando Zaragoza-Contreras, Juana Melgoza-Lozano
Summary: The study demonstrates that Aloe vera hydrogel can enhance wound healing speed, reduce the total healing time, and achieve complete wound closure in 15 days. The results confirm the good interaction of the hydrogel with proteins and growth factors, as well as the microstructure and micro-roughness that promote good adhesion to the wound.
Article
Pharmacology & Pharmacy
Qijun Li, Shiqiang Gong, Weifan Yao, Ziting Yang, Renjun Wang, Zhaojin Yu, Minjie Wei
Summary: This study utilized a dual-sensitive hydrogel loaded with exosomes derived from hUCMSCs to promote wound healing and skin regeneration, showing significant improvements in wound closure, re-epithelialization rates, and collagen deposition in the wound sites. The results suggest the potential for achieving complete skin regeneration through the use of this novel approach.
Article
Chemistry, Multidisciplinary
Amirah Ahmad, Mohd Hasmizam Razali, Mazidah Mamat, Karimah Kassim, Khairul Anuar Mat Amin
ARABIAN JOURNAL OF CHEMISTRY
(2020)
Article
Materials Science, Biomaterials
Nur Arifah Ismail, Khairul Anuar Mat Amin, Fadzillah Adibah Abdul Majid, Mohd Hasmizam Razali
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Article
Chemistry, Multidisciplinary
Mohd Hasmizam Razali, Ahmad Fauzi Mohd Noor, Mahani Yusoff
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
(2020)
Article
Polymer Science
Muhammad Zulhelmi Muktar, Muhammad Ameerul Amin Bakar, Khairul Anuar Mat Amin, Laili Che Rose, Wan Iryani Wan Ismail, Mohd Hasmizam Razali, Saiful Izwan Abd Razak, Marc in het Panhuis
Summary: The study developed wound dressing materials using gellan gum and virgin coconut oil, examining their chemical interaction, mechanical performance, physical properties, and thermal behavior. The results showed that the stress-at-break and Young's modulus of the GVCO hydrogel increased with the inclusion of VCO microemulsion, suggesting its potential as a biomedical material.
Article
Nanoscience & Nanotechnology
Mohd Hasmizam Razali, Muhammad Amir Fikri Md Fauzi, Basirah Mohd Azam, Mahani Yusoff
Summary: In this research, g-C3N4/TiO2 nanocomposite was prepared using a hydrothermal method and used as a photocatalyst for dye degradation. The characterization of g-C3N4/TiO2 showed the presence of anatase and rutile phases of TiO2 and layered structure of g-C3N4. The nanocomposite demonstrated higher photocatalytic activity compared to pure g-C3N4 and TiO2, degrading the dye under visible light.
APPLIED NANOSCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Muhammad Amir Fikri Md Fauzi, Mohd Hasmizam Razali, Md Uwaisulqarni Osman, Basirah Mohd Azam
Summary: The study found that the heterostructure of TiO2/g-C3N4 exhibits better photocatalytic activity and shows advantages in degrading dyes, especially methylene blue and caffeine.
ADVANCES IN MATERIALS AND PROCESSING TECHNOLOGIES
(2022)
Article
Biochemistry & Molecular Biology
Jichao Liu, Nur Arifah Ismail, Mahani Yusoff, Mohd Hasmizam Razali
Summary: A wound healing dressing based on a natural polymer of gellan gum, incorporating zinc oxide nanoparticles and multiwall carbon nanotubes, was fabricated. The film showed enhanced fluid uptake and good antibacterial properties, enabling accelerated wound healing.
BIOINORGANIC CHEMISTRY AND APPLICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Dagne Bayih Adamu, Enyew Zereffa, Teshome Abdo Segne, Mohd Hasmizam Razali, Bundi Roba Lemu
Summary: Excessive consumption of fluoride ions in drinking water can be harmful to human health, therefore, novel and efficient nanomaterials synthesized through eco-friendly methods are needed to remove fluoride ions. Pure and iron-doped hydroxyapatites were synthesized using a co-precipitation technique and characterized using advanced tools. The materials exhibited a decrease in crystallite size and crystallinity with calcium substitution, but an increase in surface area and pore volume with iron modification. Batch adsorption experiments showed that the sorption process is chemisorption on a homogenous surface. The maximum sorption capacities of HA and Fe-HA were 40.46 and 83.86 mg g(-1), respectively. Thermodynamic data indicated that the adsorption process is endothermic and spontaneous. Regeneration and reuse analysis confirmed the materials' potential for reuse. The adsorption mechanism involved electrostatic interaction and ion exchange. The use of iron-modified hydroxyapatite was shown to be effective in removing fluoride ions.
MATERIALS RESEARCH EXPRESS
(2023)
Article
Green & Sustainable Science & Technology
Sayyed Jaheera Anwar, Irshad Ul Haq Bhat, Hanis Mohd Yusoff, Mohd Hasmizam Razali, Maisara Abdul Kadir, Lee Khai Ern
Summary: This study describes a simple green one-pot synthesis method for preparing Palladium Nanocatalyst (PdNC) using the crude extract of Saragassum cervicorne seaweed. The PdNC showed enhanced catalytic activity in the reduction of harmful azo dyes, making it a promising catalytic material obtained through a green synthetic approach.
CLEANER ENGINEERING AND TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Sharmili Silvarajoo, Uwaisulqarni M. Osman, Khadijah H. Kamarudin, Mohd Hasmizam Razali, Hanis Mohd Yusoff, Irshad Ul Haq Bhat, Mohd Zul Helmi Rozaini, Yusnita Juahir
Article
Multidisciplinary Sciences
Mohd Hasmizam Razali, Nur Arifah Ismail, Khairul Anuar Mat Amin
Article
Multidisciplinary Sciences
Mohd Hasmizam Razali, Nur Arifah Ismail, Uwaisulqarni M. Osman, Mohd Zul Helmi Rozaini, Mahani Yusoff
Article
Multidisciplinary Sciences
Uwaisulqarni M. Osman, Azieda Syafika N. Farizal, Maisara Abdul Kadir, Mohd Hasmizam Razali, Mohd Zul Helmi Rozaini, Suhana Arshad
Proceedings Paper
Materials Science, Multidisciplinary
Intan Harnila Abdullah, Mohamad Najmi Masri, Mohd Hasmizam Razali, Mahani Yusoff
MATERIALS CHARACTERIZATION USING X-RAYS AND RELATED TECHNIQUES
(2019)