4.6 Article

Organocatalytic Enantioselective Aza-Michael Reaction of Benzotriazole to ,-Disubstituted Nitroalkenes

Journal

CHEMCATCHEM
Volume 7, Issue 13, Pages 1935-1938

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/cctc.201500373

Keywords

asymmetric catalysis; aza-Michael reaction; benzotriazoles; Michael addition; organocatalysis

Funding

  1. National Natural Science Foundation of China [21102145]
  2. Guangdong Pearl River Nova Program [2012J2200014]

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An enantioselective aza-Michael reaction of benzotriazole to ,-disubstituted nitroalkenes has been developed. This reaction was catalyzed efficiently by a bifunctional thiourea catalyst, affording the corresponding products, bearing quaternary stereogenic centers, in moderate to high yields (up to 80%) and with high enantioselectivities of up to 95% ee.

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