Article
Chemistry, Multidisciplinary
Feiyi Sun, Hanchen Shen, Qingqing Liu, Yuyang Chen, Weihua Guo, Wutong Du, Changhuo Xu, Bingzhe Wang, Guichuan Xing, Zhuwei Jin, Jacky W. Y. Lam, Jianwei Sun, Ruquan Ye, Ryan T. K. Kwok, Jianping Chen, Ben Zhong Tang
Summary: In this study, theranostic nanoparticles consisting of isoliquiritigenin (ISL) and a near-infrared photosensitizer TBPI were created for combined chemo- and photodynamic therapies for breast cancer. The nanoparticles showed high affinity for breast cancer cells, enhanced tumor-killing efficacy, and reduced drug dosage and side effects.
Article
Clinical Neurology
Song Li, Zhengzhi Wu, Weidong Le
Summary: In Western medicine, dementia affects cognition, mental health, and physical abilities, while Traditional Chinese Medicine explains it from the perspectives of brain dystrophy, Spleen-Kidney weakness, Blood stasis, and Phlegm stagnation. Ancient Chinese physicians believed that dementia manifests not only as cognitive symptoms but also as psychiatric disorders and sleep disturbance, offering various treatment methods.
ALZHEIMERS & DEMENTIA
(2021)
Review
Pharmacology & Pharmacy
Xue Bai, Meng Zhang
Summary: Research has shown that traditional Chinese medicine has a clinical impact on vascular dementia, improving patients' cognitive function and quality of life. The pharmacological mechanisms of TCM for VD treatment include targeting the kidneys, eliminating turbidity, and promoting blood circulation, indicating promising prospects.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Lei Li, Man Wang, Jikuai Chen, Juelin Chen, Yawei Wang, Minghao Zhao, Qing Song, Shuogui Xu
Summary: As global warming continues, heat waves are becoming more frequent and intense, leading to an increase in the incidence of heat stroke. Heat stroke is associated with significant morbidity and mortality, and further research is urgently needed to address this issue. Traditional Chinese medicine offers potential treatment methods, including herbal therapies and external treatments, which may provide clinical benefits and research directions for heat stroke.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Ming Lyu, Guanwei Fan, Guangxu Xiao, Taiyi Wang, Dong Xu, Jie Gao, Shaoqin Ge, Qingling Li, Yuling Ma, Han Zhang, Jigang Wang, Yuanlu Cui, Junhua Zhang, Yan Zhu, Boli Zhang
Summary: The COVID-19 pandemic poses a significant threat to global public health and safety, with the crucial role and potential mechanisms of Traditional Chinese Medicine (TCM) in combination with Western medicine highlighted and discussed. A comprehensive review of the clinical effects and potential mechanisms of TCM on COVID-19 is presented, aiming to provide reference for healthcare professionals and the public, and facilitate understanding of the true scientific value of TCM.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Pharmacology & Pharmacy
Chien-Yu Ko, Jung Chao, Pei-Yu Chen, Shan-Yu Su, Tomoji Maeda, Chin-Yu Lin, Hung-Che Chiang, Shyh-Shyun Huang
Summary: The study investigated 74 skin whitening prescriptions sold in TCM pharmacies in Taiwan, revealing 90 traditional Chinese medicinal materials mainly sourced from Apiaceae and Leguminosae. Oral prescriptions were mostly warm and sweet, while external prescriptions included cold and bitter medicinal materials, with a focus on tonifying and replenishing effects. Pharmacological analysis indicated potential benefits for wound healing, inflammatory skin diseases, and anti-hyperpigmentation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Wei Zhuang, Shao-Li Liu, Sheng-Yan Xi, Ying-Nan Feng, Ke Wang, Teliebald Abduwali, Ping Liu, Xiao-Jiang Zhou, Lan Zhang, Xian-Zhe Dong
Summary: This article summarizes the frequently used traditional Chinese medicine decoctions and Chinese patent medicines for treating depression, reviews their clinical therapeutic effects and possible mechanisms, and highlights the importance of traditional Chinese medicine in the management of depression.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Zhihua Yang, Shanshan Lin, Yangxi Liu, Qiuan Ren, Zhao Ge, Ci Wang, Yingfei Bi, Xianliang Wang, Jingyuan Mao
Summary: Coronary microvascular disease (CMVD) is common in patients with cardiovascular risk factors and is associated with an increased risk of adverse cardiovascular events. Traditional Chinese medicine (TCM), with its clinical advantages of syndrome differentiation and individualized treatment, shows potential efficacy and action mechanisms for CMVD. However, there are still many scientific issues and gaps in the research of CMVD.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Chao Mo, Jie Zhao, Jingyan Liang, Huiling Wang, Yu Chen, Guodong Huang
Summary: Exosomes play a crucial role in intercellular communication, and the interaction between exosomes and traditional Chinese medicine (TCM) has beneficial effects on various diseases. TCM formulas and compounds can modulate exosomes to inhibit cell proliferation, reduce inflammation, and attenuate fibrosis. Additionally, exosomes serve as a natural delivery system for TCM compounds, and they may also be potential biomarkers for TCM syndromes.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Bao-Hong Li, Zhong-Yuan Li, Miao-Miao Liu, Jing-Zhen Tian, Qing-Hua Cui
Summary: Traditional Chinese medicine has unique advantages in the treatment of respiratory virus diseases by using the strategies of dispelling evil and fu zheng.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Chemistry, Medicinal
Huimei Liu, Li Zhu, Linxi Chen, Lanfang Li
Summary: Traditional Chinese medicine has therapeutic effects on atherosclerosis, with pharmacological roles involving endothelial function, cell proliferation and migration, platelet aggregation, and more. However, some traditional Chinese medicines may have toxic effects, requiring further research on their clinical safety and efficacy.
PHYTOTHERAPY RESEARCH
(2022)
Article
Integrative & Complementary Medicine
Xia Zhang, Mingqi Wang, Wen Wang, Ling Li, Xin Sun
Summary: The study found that traditional Chinese medicine (TCM) was widely used among ICU patients, particularly TCM injections and oral liquids. There were differences in the use of TCM between different ICUs. The use of TCM was also closely associated with patient characteristics.
Review
Environmental Sciences
Tingting Yao, Shunyuan Jiang, Kai Hou, Hui Sun, Honglan Wang
Summary: In the context of serious environmental pollution, the potential harm caused by toxic heavy metals in traditional Chinese medicine materials (TCMMs) has seriously affected the sustainable development of traditional Chinese medicine. This study found that a portion of TCMM samples exceeded the domestic standards for cadmium (Cd) content, and the decrease in soil acidity and improvement of Cd-hyperaccumulator cultivation conditions are crucial for ensuring the sustainable development of traditional Chinese medicine.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Endocrinology & Metabolism
Natural Chu, Juliana C. N. Chan, Elaine Chow
Summary: Pharmacomicrobiomics investigates the interactions between foreign compounds and the gut microbiome, which play a significant role in the efficacy, side effects, and toxicity of the compounds. Glucose lowering drugs work by regulating insulin and energy disposal. In addition to genetic, ecological, and lifestyle factors, maintaining a balanced gut microbiome is crucial for human health. Different compositions of microbiota can influence patients' responses to glucose-lowering drugs. This article summarizes the differences in gut microbiota composition between individuals with type 2 diabetes and healthy individuals, and explores how Western Medicine and Traditional Chinese Medicine can shape the gut microbiota to improve immunity and metabolic health.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Pharmacology & Pharmacy
Mingtai Chen, Ying Xie, Shenglan Gong, Yunqiao Wang, Hao Yu, Tianran Zhou, Furong Huang, Xin Guo, Huanhuan Zhang, Ruolan Huang, Zhiyi Han, Yufeng Xing, Qiang Liu, Guangdong Tong, Hua Zhou
Summary: NASH is a common chronic liver disease in clinical practice with no officially approved pharmacological therapy. Traditional Chinese medicine has been proven beneficial in treating NASH in multiple studies, providing a potential therapy for this condition.
PHARMACOLOGICAL RESEARCH
(2021)