Editorial Material
Genetics & Heredity
Tim Caro
Summary: American black bears exhibit color polymorphism, and a recent study suggests that a gene mutation is responsible for the cinnamon color variant in the southwest USA. However, the adaptive significance of these color variations in this large carnivore remains unclear.
TRENDS IN GENETICS
(2023)
Article
Health Care Sciences & Services
Renato Fernandes, Halil Irahim Ceylan, Filipe Manuel Clemente, Joao Paulo Brito, Alexandre Duarte Martins, Hadi Nobari, Victor Machado Reis, Rafael Oliveira
Summary: This study investigated the microcycle of training for professional female soccer players and found that internal and external intensities were higher in matches compared to training. The highest intensities were observed during match days and in the beginning of the training week, while the lowest intensities were found in the training session before the match. There were no significant differences in wellness parameters between training days and match days.
Article
Virology
Isidro Hotzel
Summary: The surface envelope protein subunit of retroviruses is highly variable, but a conserved core domain has been identified that underlies the structural diversity of orthoretroviral SU and filoviral GP(1).
JOURNAL OF VIROLOGY
(2022)
Article
Microbiology
Adam Schafer, Rui Xiong, Laura Cooper, Raghad Nowar, Hyun Lee, Yangfeng Li, Benjamin E. Ramirez, Norton P. Peet, Michael Caffrey, Gregory R. J. Thatcher, Erica Ollmann Saphire, Han Cheng, Lijun Rong
Summary: Filoviruses, such as Ebola and Marburg viruses, are highly dangerous pathogens with high mortality rates, highlighting the need for novel therapeutics. Despite many potential entry inhibitors, the lack of understanding of their mechanisms of action has contributed to a high failure rate. This report provides molecular insights into multiple mechanisms of action by small molecule inhibitors, offering important guidance for future antiviral drug development.
Review
Oncology
John L. Marshall, Beth N. Peshkin, Takayuki Yoshino, Jakob Vowinckel, Havard E. Danielsen, Gerry Melino, Ioannis Tsamardinos, Christian Haudenschild, David J. Kerr, Carlos Sampaio, Sun Young Rha, Kevin T. FitzGerald, Eric C. Holland, David Gallagher, Jesus Garcia-Foncillas, Hartmut Juhl
Summary: This paper discusses the development and importance of multiomics in clinical practice, highlighting the knowledge gap within the medical community and urging physicians to actively adapt and prepare for this new era.
Article
Immunology
Shu Yuan, Si-Cong Jiang, Zhong-Wei Zhang, Yu-Fan Fu, Jing Hu, Zi-Lin Li
Summary: Cytokine storms triggered by highly pathogenic virus infections can have adverse effects on vital organs. Interleukin (IL)-4 and interferon (IFN)-gamma play key roles in regulating cytokine storms. Different viruses may induce different cytokines with varying amplitudes, and specific mathematical formulas apply to IFN-gamma-inducible infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Environmental Sciences
Ana Rotter, Michele Barbier, Francesco Bertoni, Atle M. Bones, M. Leonor Cancela, Jens Carlsson, Maria F. Carvalho, Marta Ceglowska, Jeronimo Chirivella-Martorell, Meltem Conk Dalay, Mercedes Cueto, Thanos Dailianis, Irem Deniz, Ana R. Diaz-Marrero, Dragana Drakulovic, Arita Dubnika, Christine Edwards, Hjoerleifur Einarsson, Aysegul Erdogan, Orhan Tufan Eroldogan, David Ezra, Stefano Fazi, Richard J. FitzGerald, Laura M. Gargan, Susana P. Gaudencio, Marija Gligora Udovic, Nadica Ivosevic DeNardis, Rosa Jonsdottir, Marija Katarzyte, Katja Klun, Jonne Kotta, Leila Ktari, Zrinka Ljubesic, Lada Lukic Bilela, Manolis Mandalakis, Alexia Massa-Gallucci, Inga Matijosyte, Hanna Mazur-Marzec, Mohamed Mehiri, Soren Laurentius Nielsen, Lucie Novoveska, Donata Overlinge, Giuseppe Perale, Praveen Ramasamy, Celine Rebours, Thorsten Reinsch, Fernando Reyes, Baruch Rinkevich, Johan Robbens, Eric Roettinger, Vita Rudovica, Jerica Sabotid, Ivo Safarik, Siret Talve, Deniz Tasdemir, Xenia Theodotou Schneider, Olivier P. Thomas, Anna Torunska-Sitarz, Giovanna Cristina Varese, Marlen Vasquez
Summary: Coastal countries have traditionally relied on marine resources for various needs, while modern societies have increased demands for diverse products leading to the emergence of blue biotechnology. This field offers opportunities for commercial interests in pharmaceuticals, cosmetics, food, and related industries. Exploration of marine resources and their potential applications in various sectors are highlighted, along with the importance of legislation, funding, communication, and stakeholder engagement in the development of marine biotechnology.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Engineering, Electrical & Electronic
Suravi Thakur, Nilanjan Senroy
Summary: This letter discusses the effect of downsampling in uncertainty quantification of stochastic input injections or fluctuations in the power system, specifically random load injections. The importance of conducting such analysis at proper time scales is emphasized to avoid contamination from power system dynamics.
IEEE TRANSACTIONS ON POWER SYSTEMS
(2022)
Article
Operations Research & Management Science
Manlio Gaudioso, Giovanni Giallombardo, Giovanna Miglionico
Summary: This paper provides a concise survey of the key ideas and developments in numerical nonsmooth optimization, with a focus on the research directions driven by the cutting plane and subgradient methods.
ANNALS OF OPERATIONS RESEARCH
(2022)
Article
Engineering, Environmental
Vivien Dubois, Eva Falipou, Catherine Boutin
Summary: The research study examines the discharges of domestic wastewater from 15 single-family dwellings, providing valuable insights into the concentrations, volumes, and pollutant loads. The data variability is quantified, suggesting the use of a load range instead of standard pollution values for designing the load of single-family households. The study also advocates for a collective sewer solution and provides pollution values per resident for optimizing the operation of decentralized wastewater treatment plants.
WATER SCIENCE AND TECHNOLOGY
(2022)
Article
Medicine, General & Internal
Vera Vaz Ferreira, Arjun K. Ghosh
Summary: Cardio-oncology is a subspecialty that provides cardiac care for cancer patients. Cardiovascular toxicity (CVT) caused by newer oncological agents has emerged as a concern, emphasizing the need for baseline assessment and individualized surveillance during and after cancer therapy. Early diagnosis and management strategies are crucial.
Article
Engineering, Electrical & Electronic
Elnaz Azizi, Mohammad T. H. Beheshti, Sadegh Bolouki
Summary: Non-intrusive load monitoring (NILM) is an efficient approach to energy management that extracts appliance consumption by analyzing aggregated signals. The presence of numerous appliances and appliances with similar consumption values poses challenges for event-based NILM methods. Semi-intrusive load monitoring offers an alternative where appliances are divided into blocks and monitored using separate power smart meters. However, this approach increases the cost of load monitoring.
IEEE TRANSACTIONS ON SMART GRID
(2022)
Article
Chemistry, Multidisciplinary
Reza Nouri, Yuqian Jiang, Anthony J. Politza, Tianyi Liu, Wallace H. Greene, Yusheng Zhu, Jonathan J. Nunez, Xiaojun Lian, Weihua Guan
Summary: This study reported a new digital CRISPR-Cas13 assay (dCRISPR) using automated membrane-based partitioning to achieve absolute quantification of HIV-1 viral RNAs. The method does not require amplification and can rapidly quantify RNA samples over a wide range in a short period of time.
Article
Medicine, General & Internal
Kieran Palmer, Emily Wang, Rakesh Mattu, Karen Tipples
Summary: This article provides an overview of the initial management of patients who experience acute complications related to their cancer diagnosis or anti-cancer treatment.
Article
Pathology
Natalie N. Kinloch, Gordon Ritchie, Winnie Dong, Kyle D. Cobarrubias, Hanwei Sudderuddin, Tanya Lawson, Nancy Matic, Julio S. G. Montaner, Victor Leung, Marc G. Romney, Christopher F. Lowe, Chanson J. Brumme, Zabrina L. Brumme
Summary: Quantitative viral load assays have been crucial in understanding viral diseases and could play a significant role in advancing COVID-19 control, but SARS-CoV-2 viral load tests are not widely available yet. Droplet digital RT-PCR is deemed an attractive platform for quantifying SARS-CoV-2 RNA, with the E-Sarbeco primer/probe set being identified as the most efficient for this purpose.
JOURNAL OF MOLECULAR DIAGNOSTICS
(2021)
Article
Virology
Alberto Paniz-Mondolfi, Susana Guerra, Marina Munoz, Nicolas Luna, Matthew M. Hernandez, Luz H. Patino, Jason Reidy, Radhika Banu, Paras Shrestha, Bernadette Liggayu, Audrey Umeaku, Feng Chen, Liyong Cao, Armi Patel, Ayman Hanna, Sunny Li, Andy Look, Nina Pagani, Randy Albrecht, Rebecca Pearl, Adolfo Garcia-Sastre, Dusan Bogunovic, Gustavo Palacios, Lucia Bonnier, Freddy Cera, Heidi Lopez, Yvette Calderon, Erick Eiting, Karr Mullen, Sangyoon Jason Shin, Luz Amarilis Lugo, Antonio E. Urbina, Carlotta Starks, Tonny Koo, Patricia Uychiat, Avery Look, Harm van Bakel, Ana Gonzalez-Reiche, Adolfo Firpo Betancourt, David Reich, Carlos Cordon-Cardo, Viviana Simon, Emilia M. Sordillo, Juan David Ramirez
Summary: Monkeypox virus is a zoonotic orthopoxvirus that is prevalent in Central and West Africa. A new real-time PCR assay for diagnosing MPXV infection in humans has been developed and validated, showing high specificity and sensitivity. The assay has been approved for clinical use by the NYS Department of Health.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Pharmacology & Pharmacy
Jens H. Kuhn, Connie S. Schmaljohn
Summary: In 1998, the first immunocompetent laboratory mouse model of Ebola virus disease was developed by Mike Bray and colleagues. Despite being considered inferior to large nonhuman primate efforts initially, this model paved the way for the establishment of panel-derived cross-bred and humanized mouse models, as well as a golden hamster model. The global shortage of commercially available large nonhuman primates may lead to an increased focus on and improvement of rodent modeling, potentially replacing nonhuman primate studies in the short term and the future.
ANTIVIRAL RESEARCH
(2023)
Article
Behavioral Sciences
Denis Nono, Nolbert Gumisiriza, Christopher Tumwine, Luis-Jorge Amaral, Herbert Elvis Ainamani, Seggane Musisi, Robert Colebunders
Summary: This study investigated the impact of the COVID-19 pandemic on the access and use of health services by children with epilepsy in Uganda. The study found that COVID-19-related restrictions created challenges for children with epilepsy, their parents, and healthcare providers, including reduced access to healthcare services, food insecurity, and inability to afford essential medicines. However, several coping strategies, such as parents engaging in casual work and healthcare workers intensifying outreach services, were adopted to address these challenges.
EPILEPSY & BEHAVIOR
(2023)
Editorial Material
Behavioral Sciences
Van Cutsem Gilles, Colebunders Robert
EPILEPSY & BEHAVIOR
(2023)
Article
Microbiology
Soya S. Sam, Ralph Rogers, Jessica Ingersoll, Colleen S. Kraft, Angela M. Caliendo
Summary: This study evaluated the performance characteristics of the Aptima CMV Quant assay compared to other FDA-approved CMV assays including Abbott RealTime CMV assay, Qiagen Artus CMV RGQ MDx assay, and Roche cobas CMV test using plasma samples. The Aptima assay showed sensitivity and accuracy in quantifying CMV in plasma specimens and yielded comparable results to other FDA-approved CMV assays.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Stuart G. Siddell, Donald B. Smith, Evelien Adriaenssens, Poliane Alfenas-Zerbini, Bas E. Dutilh, Maria Laura Garcia, Sandra Junglen, Mart Krupovic, Jens H. Kuhn, Amy J. Lambert, Elliot J. Lefkowitz, Malgorzata Lobocka, Arcady R. Mushegian, Hanna M. Oksanen, David L. Robertson, Luisa Rubino, Sead Sabanadzovic, Peter Simmonds, Nobuhiro Suzuki, Koenraad Van Doorslaer, Anne-Mieke Vandamme, Arvind Varsani, F. Murilo Zerbini
Summary: The International Committee on Taxonomy of Viruses (ICTV) is responsible for the development and oversight of virus taxonomy. It approves and ratifies taxonomic proposals and maintains a list of approved virus names. The ICTV has a democratic decision-making process with approximately 180 members who vote on proposals. Taxon-specific Study Groups, comprised of over 600 scientists, provide expertise and contribute to taxonomic proposals.
JOURNAL OF GENERAL VIROLOGY
(2023)
Review
Clinical Neurology
G. Van Cutsem, J. N. Siewe Fodjo, M. C. J. Dekker, L. J. Amaral, A. K. Njamnshi, R. Colebunders
Summary: Onchocerciasis-associated epilepsy (OAE) is a neglected public health problem in areas with inadequate onchocerciasis control. An internationally accepted case definition of OAE is needed to identify areas requiring treatment and prevention interventions. By including OAE as a manifestation of onchocerciasis, accuracy of disease burden estimation will be improved and more support for research and control efforts can be expected.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2023)
Editorial Material
Virology
Jens H. Kuhn, Steven B. Bradfute, Charles H. Calisher, Boris Klempa, Jonas Klingstrom, Lies Laenen, Gustavo Palacios, Connie S. Schmaljohn, Nicole D. Tischler, Piet Maes
Summary: The official classification of viruses by the ICTV requires complete or nearly complete genome sequences to be deposited in GenBank. This requirement is fairly new, resulting in fragmented or absent genomic sequence information for many classified viruses. This poses challenges for taxon-wide phylogenetic analyses, especially for viruses with segmented genomes. To address this issue for Hantaviridae, the community is urged to provide additional sequence information for incompletely sequenced classified viruses by mid-June 2023 to prevent possible declassification.
Article
Immunology
Luz H. Patino, Susana Guerra, Marina Munoz, Nicolas Luna, Keith Farrugia, Adriana van de Guchte, Zain Khalil, Ana Silvia Gonzalez-Reiche, Matthew M. Hernandez, Radhika Banu, Paras Shrestha, Bernadette Liggayu, Adolfo Firpo Betancourt, David Reich, Carlos Cordon-Cardo, Randy Albrecht, Rebecca Pearl, Viviana Simon, Aria Rooker, Emilia Mia Sordillo, Harm van Bakel, Adolfo Garcia-Sastre, Dusan Bogunovic, Gustavo Palacios, Alberto Paniz Mondolfi, Juan David Ramirez
Summary: Monkeypox (MPOX) is an animal-borne infectious disease endemic to Central/Western Africa. A large multi-country outbreak of MPV, originating in Europe with no links to endemic countries, has rapidly spread worldwide, prompting genomic surveillance efforts. Genomic analysis of MPV-infected patients from New York City revealed that the circulating strains belong to the B.1 lineage, with further differentiation into five sub-lineages. Mutational analysis identified 55 non-synonymous polymorphisms, including those in critical regions for viral function and antiviral treatment target. Comparison between clinical isolates and culture-passaged samples showed no difference.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Virology
Nadine Biedenkopf, Alexander Bukreyev, Kartik Chandran, Nicholas Di Paola, Pierre B. H. Formenty, Anthony Griffiths, Adam J. Hume, Elke Muehlberger, Sergey V. Netesov, Gustavo Palacios, Janusz T. Paweska, Sophie Smither, Ayato Takada, Victoria Wahl, Jens H. Kuhn
Summary: The International Committee on Taxonomy of Viruses (ICTV) Filoviridae Study Group continues to refine the taxonomy and nomenclature of family Filoviridae in order to reduce confusion and adhere to ICVCN stipulations. Recent changes include the renaming of the genera Ebolavirus and Marburgvirus to Orthoebolavirus and Orthomarburgvirus, respectively. All established species names now follow the ICTV-mandated binomial format. Virus names remain unchanged. Here, we present the revised taxonomy of family Filoviridae approved by the ICTV in April 2023.
ARCHIVES OF VIROLOGY
(2023)
Article
Behavioral Sciences
Luis-Jorge Amaral, Dan Bhwana, Messaline F. Fomo, Bruno P. Mmbando, Carmen-Nabintu Chigoho, Robert Colebunders
Summary: This study examined the quality of life of adults with epilepsy in an onchocerciasis-endemic area in Tanzania. The findings revealed that individuals with epilepsy in this region have a lower quality of life, highlighting the need to improve medication regimens and education levels.
EPILEPSY & BEHAVIOR
(2023)
Article
Public, Environmental & Occupational Health
Jessica A. Tarabay, Jill S. Morgan, Colleen S. Kraft, Mary Elizabeth Sexton
Summary: Hospitals dealing with high-consequence pathogens must handle a large amount of category A waste safely. They identified and validated autoclave cycle parameters that would effectively sterilize 4 categories of waste by using biological indicators and the STERIS Amsco 630LS Steam Sterilizer.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Virology
Teressa M. Shaw, Sara M. Maloney, Kylie Nennig, Mitchell D. Ramuta, Andrew Norton, Rodrigo Ibarra, Paul Kuehnert, Margo Brinton, Kay Faaberg, Jens H. Kuhn, David H. O'Connor, Cody J. Warren, Adam L. Bailey
Summary: Arteriviruses, including lactate dehydrogenase-elevating virus (LDV), have been identified as RNA viruses related to coronaviruses. LDV is a valuable model for studying immune failure and viral persistence in immunocompetent mice. This study demonstrates that the macrophage marker CD163 is essential for LDV infection and the establishment of an immortalized cell-culture system. Additionally, LDV infection can be completely resisted in knockout mice lacking the expression of mCD163. The findings contribute to the understanding of arterivirus infection and highlight the significance of CD163 utilization in this virus family.
JOURNAL OF VIROLOGY
(2023)
Review
Clinical Neurology
Joseph Nelson Siewe Fodjo, Gilles Van Cutsem, Luis-Jorge Amaral, Robert Colebunders
Summary: This study aims to investigate epilepsy-related mortality in sub-Saharan Africa (SSA) and its possible association with onchocerciasis endemicity. The results showed that high-risk onchocerciasis sites had higher mortality rates and case fatality rates compared to low-risk sites. The leading causes of epilepsy-related deaths were status epilepticus, drowning, and sudden unexpected death in epilepsy. This suggests the urgent need for better epilepsy prevention and care in onchocerciasis-endemic areas in SSA.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2023)
Review
Virology
Mohammad Fereidouni, Dmitry A. Apanaskevich, David B. Pecor, Natalia Yu. Pshenichnaya, Gulzhan N. Abuova, Farida H. Tishkova, Yekaterina Bumburidi, Xiankun Zeng, Jens H. Kuhn, Maryam Keshtkar-Jahromi
Summary: This study summarizes the status of Crimean-Congo hemorrhagic fever (CCHF) in Central, Eastern, and South-eastern Asia. The risk and burden of CCHF were assessed based on case reports, antibody prevalence, and vector ticks isolation. The majority of cases were reported in Central Asia, while only China reported cases in Eastern Asia. No cases were reported in South-eastern Asia. Countries were classified into different levels based on evidence of CCHF, guiding the strengthening or establishment of CCHF surveillance systems.
