Journal
LANCET INFECTIOUS DISEASES
Volume 16, Issue 3, Pages E13-E22Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1473-3099(15)00537-X
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Recent advances in medical microbiology, epidemiology, cellular biology, and the availability of an expanded set of diagnostic methods such as histopathology, immunohistochemistry, PCR, and bacterial culture have improved our understanding of the clinical range and natural course of Tropheryma whipplei infection and Whipple's disease. Interdisciplinary and transnational research activities have contributed to the clarification of the pathogenesis of the disorder and have enabled controlled trials of different treatment strategies. We summarise the current knowledge and new findings relating to T whipplei infection and Whipple's disease.
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