Article
Microbiology
James S. Lewis, Nathan P. Wiederhold, Morgan Hakki, George R. Thompson
Summary: Isavuconazole is a newly available antifungal drug that is effective against various fungi. It is FDA-approved for the treatment of invasive aspergillosis and mucormycosis. Isavuconazole has significant advantages over other antifungal drugs, such as lack of QTc interval prolongation, more predictable pharmacokinetics, a simpler drug interaction profile, and improved tolerability.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Engineering, Biomedical
Agnieszka Dabrowska, Pawel Botwina, Emilia Barreto-Duran, Agata Kubisiak, Magdalena Obloza, Aleksandra Synowiec, Artur Szczepanski, Marta Targosz-Korecka, Krzysztof Szczubialka, Maria Nowakowska, Krzysztof Pyrc
Summary: This study proposes a method of using polymers to combat broad-spectrum viral infections. By modulating the nano-mechanical properties of cells, these polymers can interfere with viral replication and reduce infection. The effectiveness of this method was validated through experimental results, and it was found that the process is reversible.
MATERIALS TODAY BIO
(2023)
Article
Chemistry, Multidisciplinary
Shan He, Chaoran Chen, Fangzheng Li, Wenxuan Xu, Dongdong Li, Ming Liang, Xianzhu Yang
Summary: This study developed a nanomaterial (S-PPE NP) containing thioether that can absorb and scavenge multiple types of ROS, preventing cellular damage. S-PPE NP showed superior therapeutic effects in AKI-bearing mice by reducing ROS and inflammation-related signaling pathways, thus reducing cell apoptosis.
Article
Chemistry, Analytical
Jie Wei, Siqian Liu, Aori Qileng, Weiwei Qin, Weipeng Liu, Kun Wang, Yingju Liu
Summary: This study developed a photoelectrochemical/colorimetric immunosensor for broad-spectrum detection of ochratoxin A, B, and C using bifunctional copper oxide nanoflowers as dual-signal probes and broad spectrum antibodies for accurate assessment. The sensor utilized two independent modes, photoelectrochemical and colorimetric, to enhance accuracy and reliability in reflecting the concentrations of ochratoxins.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Materials Science, Multidisciplinary
Jinsen Han, Hongli Guo, Xiaoxiang Yu, Kang Lai, Jiahao Chen, Dongdong Kang, Jiayu Dai
Summary: A strategy to split bright exciton bands is proposed to achieve broad-spectrum absorption in two-dimensional semiconductors. Based on calculations using ab initio many-body perturbation theory and Bethe-Salpeter equation, it is predicted that post-transition-metal chalcogenides monolayers can realize broadband absorption under biaxial tensile strains. This work provides a new perspective to engineer two-dimensional materials with superior optoelectronic properties.
MATERIALS TODAY PHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Li-Guo Liao, Duo Ke, Guo-Chen Li, Sheng Zhang, Bang-Jing Li
Summary: The important role of gasotransmitters in physiology and pathophysiology suggests using them for biomedical treatment. However, difficulties in storage and controlled delivery hinder the development of effective gasotransmitters-based therapies. Here, a gamma-cyclodextrin metal organic framework (gamma-CD-MOF) is used as a delivery vehicle for various gasotransmitters, with the release rate being tunable by modifying the gamma-CD-MOF with different Pluronics. The biological relevance of the gasotransmitters produced by this method is demonstrated by their DNA cleavage ability and anti-inflammatory effects.
Article
Chemistry, Organic
Chi-Lin Kuo, Qin Su, Adrianus M. C. H. van den Nieuwendijk, Thomas J. M. Beenakker, Wendy A. Offen, Lianne I. Willems, Rolf. G. Boot, Alexi J. Sarris, Andre R. A. Marques, Jeroen D. C. Codee, Gijsbert A. van der Marel, Bogdan I. Florea, Gideon J. Davies, Herman S. Overkleeft, Johannes M. F. G. Aerts
Summary: This study introduces a method using fluorescent and biotin-carrying activity-based probes to assess the activity of GLB1 and GALC. These probes can assist in the research of various β-galactosidases causing lysosomal storage disorders.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Organic
Chi-Lin Kuo, Qin Su, Adrianus M. C. H. van den Nieuwendijk, Thomas J. M. Beenakker, Wendy A. Offen, Lianne I. Willems, Rolf. G. Boot, Alexi J. Sarris, Andre R. A. Marques, Jeroen D. C. Codee, Gijsbert A. van der Marel, Bogdan I. Florea, Gideon J. Davies, Herman S. Overkleeft, Johannes M. F. G. Aerts
Summary: This study describes the use of fluorescent and biotin-carrying activity-based probes to assess the activity of acid β-galactosidase (GLB1) and galactocerebrosidase (GALC). These probes are important for fundamental and clinical research on lysosomal storage disorders caused by inherited deficiencies.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Physical
Mengxia Ji, Yifan Shao, Emmanuel Nkudede, Zihan Liu, Xing Sun, Junze Zhao, Ziran Chen, Sheng Yin, Huaming Li, Jiexiang Xia
Summary: In this study, a high-efficient broad-spectrum photocatalyst with surface oxygen vacancy was successfully fabricated, extending its absorption region and improving the degradation efficiency of ciprofloxacin. The research demonstrated the significant influence of oxygen vacancy on the catalytic efficiency.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Microbiology
Pei Song, Li Zhao, Li Zhu, Gan Sha, Wubei Dong
Summary: This study addresses the critical need for new antibacterial drugs in the face of bacterial multidrug resistance resulting from antibiotic overuse. It highlights the significance of antimicrobial peptides as essential components of innate immunity in animals and plants, which have been proven effective against multidrug-resistant bacteria and are difficult to develop resistance against. This study successfully synthesizes a broad-spectrum antibacterial peptide, BsR1, with strong inhibitory activities against various Gram-positive and Gram-negative bacteria. BsR1 demonstrates favorable stability and a mode of action that damages bacterial cell membranes, leading to cell death. It also exhibits biological safety and shows potential in enhancing disease resistance in rice. This research offers a novel approach and potential medication for antibacterial drug development, presenting a valuable tool in combating pathogenic microorganisms, particularly in plants.
MICROBIOLOGY SPECTRUM
(2023)
Article
Food Science & Technology
Youxue Wu, Meijiao Wu, Cheng Liu, Yachen Tian, Shuiqin Fang, Hao Yang, Bin Li, Qing Liu
Summary: The study has developed a rapid, simple, and sensitive colloidal gold immunochromatographic test strip for detecting Salmonella, with the ability to detect multiple strains within minutes, important for food safety.
Article
Infectious Diseases
Didi Bury, Tom F. W. Wolfs, Rob ter Heine, Eline W. Muilwijk, Kim C. M. van der Elst, Wim J. E. Tissing, Roger J. M. Brueggemann
Summary: This study investigated the pharmacokinetics of isavuconazole in a pediatric cohort and found low bioavailability after nasogastric tube administration. The drug exposures were within the expected range following intravenous administration, and the pharmacokinetics of total and unbound isavuconazole were reported with a 5-fold range in the unbound fraction.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Virology
Ruben Soto-Acosta, Tiffany C. Edwards, Christine D. Dreis, Venkatramana D. Krishna, Maxim C-J Cheeran, Li Qiu, Jiashu Xie, Laurent F. Bonnac, Robert J. Geraghty
Summary: The study demonstrates that combining nucleobases like favipiravir or T-1105 with the antimetabolite 6-methylmercaptopurine riboside (6MMPr) can effectively reduce replication of flavivirus, orthomyxovirus, and coronavirus, by increasing the conversion of the antiviral nucleobase to its active forms and reducing levels of competing cellular NTPs. This research provides a foundation for developing small molecules as potential co-treatments with nucleobases to combat emerging RNA virus infections.
Review
Immunology
Kensuke Miyake, Junya Ito, Hajime Karasuyama
Summary: Basophils are a rare type of granulocyte that have been overlooked in immunological research. Recent studies have revealed their non-redundant functions in immune responses and their involvement in various diseases. Basophils can either ameliorate or exacerbate inflammation, depending on the disease model. Further research on basophil biology could lead to the identification of novel biomarkers or therapeutic targets for a wide range of diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Weixi Li, Xinyue Mi, Xuanxiang Jin, Daiwei Zhang, Guozhong Zhu, Xiaoguang Shang, Dayong Zhang, Wangzhen Guo
Summary: By analyzing the transcriptional changes and co-expression analysis of cotton root tissues under abiotic and biotic stress conditions, this study identified common stress-responsive genes and stress metabolism pathways. Thiamine metabolism was found to be an important intersection between abiotic and biotic stresses, and exogenous thiamine application enhanced stress tolerance in cotton by increasing calcium signal transduction and activating downstream stress-responsive genes.
Article
Computer Science, Interdisciplinary Applications
Vlada Rozova, Anna Khanina, Jasmine C. Teng, Joanne S. K. Teh, Leon J. Worth, Monica A. Slavin, Karin A. Thursky, Karin Verspoor
Summary: Invasive fungal infections (IFIs) pose significant risks to high-risk patients and hinder cancer therapy. Surveillance of IFI in clinical settings offers potential for identifying risk factors and evaluating new treatments. By using natural language processing (NLP) on pathology reports, we developed an automated system for detecting IFI evidence and achieved improved performance by extracting targeted information.
JOURNAL OF BIOMEDICAL INFORMATICS
(2023)
Review
Infectious Diseases
Gemma Reynolds, Beatrice Sim, Mary Ann Anderson, Tim Spelman, Benjamin W. Teh, Monica A. Slavin, Karin A. Thursky
Summary: CAR-T-treated patients with haematological malignancies are at risk of infections, with prior therapies, neutropenia, steroid administration, and immuneeffector cell-associated neurotoxicity being the most associated risk factors. Biochemical markers and cytokine profiles do not reliably predict infections. Predictors of viral, bacterial, and fungal infections are poorly studied.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Review
Infectious Diseases
Chin Fen Neoh, Wirawan Jeong, David C. M. Kong, Monica A. Slavin
Summary: In the past two decades, there have been urgent needs for new antifungal agents due to the emergence of resistant fungi, the growing at-risk patient populations for invasive fungal diseases (IFD), and the high morbidity and mortality associated with IFD. This review discusses five promising antifungal agents for IFD (i.e. fosmanogepix, ibrexafungerp, olorofim, rezafungin, and opelconazole), currently in late-phase clinical studies and likely to be available for clinical use soon. The mechanisms of action, pharmacokinetic and pharmacodynamic properties, spectrum of activity, safety, and efficacy data of each agent, including ongoing clinical trials, are described. The potential roles of these novel antifungals in clinical practice and the key considerations for clinical use are also discussed.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2023)
Article
Infectious Diseases
A. Khanina, A. P. Douglas, D. K. Yeoh, M. So, J. Abbotsford, T. Spelman, D. C. M. Kong, M. A. Slavin, K. A. Thursky
Summary: The Antifungal National Antimicrobial Prescribing Survey (AF-NAPS) tool was assessed for its validity and reliability. The tool was found to be generally accurate, but some incorrect classifications were identified. The aim is to address the reasons for incorrect classification through online tools and educational materials.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Immunology
Clea Melenotte, Vishukumar Aimanianda, Monica Slavin, Jose Maria Aguado, Darius Armstrong-James, Yee-Chun Chen, Shahid Husain, Christian Van Delden, Faouzi Saliba, Agnes Lefort, Francoise Botterel, Olivier Lortholary
Summary: Invasive aspergillosis is a rare but serious infection in liver transplant recipients, with a high mortality rate. Risk factors before, during, and after transplantation have been identified, and accurate diagnosis requires collaboration between radiology and clinical biology. It is recommended to reduce the dose of tacrolimus and closely monitor blood levels when using certain drugs, and surgery should be considered on a case-by-case basis. Antifungal prophylaxis and environmental measures should be implemented to prevent outbreaks.
TRANSPLANT INFECTIOUS DISEASE
(2023)
Article
Public, Environmental & Occupational Health
Eliza Watson, Leslie Dowson, David Dunt, Karin Thursky, Leon J. Worth, Janet K. Sluggett, Amanda Appathurai, Noleen Bennett
Summary: The study identified barriers to participation in aged care infection surveillance programs, such as time-consuming data collection, competing tasks, limited understanding among some staff, difficulty engaging clinicians, and staff fatigue post-COVID-19. Enablers included previous experience with surveillance, sharing responsibilities, educational materials, and using data for benchmarking and practice improvement.
Article
Computer Science, Information Systems
Claudia Corrente, Saravanan Satkumaran, Ahuva Segal, Coen Butters, Corinne Fernandez, Franz E. Babl, Lisa M. Orme, Karin Thursky, Gabrielle M. Haeusler
Summary: This study evaluated the accuracy and impact of a clinical-facing best practice advisory (BPA) embedded into an electronic medical record workflow. The results showed poor sensitivity and limited impact on clinician behavior, indicating the need for improvement.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2023)
Editorial Material
Immunology
Paul M. Kinsella, Michelle K. Yong, Monica A. Slavin, Victoria G. Hall
TRANSPLANT INFECTIOUS DISEASE
(2023)
Editorial Material
Immunology
Benjamin W. Teh, Malgorzata Mikulska, Nicolas J. Mueller, Monica A. Slavin
TRANSPLANT INFECTIOUS DISEASE
(2023)
Review
Immunology
Nikhil Singh, Karin Thursky, Gabriela Maron, Joshua Wolf
TRANSPLANT INFECTIOUS DISEASE
(2023)
Review
Immunology
Michelle K. Yong, Monica A. Slavin, Roy F. Chemaly, Genovefa A. Papanicolaou
Summary: In recent years, there has been a significant shift in the preferred strategy for preventing CMV in at-risk populations in alloHCT. Letermovir prophylaxis is now offered to all CMV seropositive recipients, resulting in significant reductions in CMV infection and other important outcomes. However, there are limitations such as delayed onset CMV infections and increased drug costs.
TRANSPLANT INFECTIOUS DISEASE
(2023)
Article
Hematology
Dionysios Neofytos, William J. Steinbach, Kimberly Hanson, Paul A. Carpenter, Genovefa A. Papanicolaou, Monica A. Slavin
Summary: The Practice Guidelines Committee of the American Society of Transplantation and Cellular Therapy (ASTCT) updated their infectious disease guidelines for hematopoietic cell transplantation (HCT) by publishing concise formats of frequently asked questions, tables, and figures. This sixth guideline focuses on invasive candidiasis (IC) and addresses its epidemiology, clinical diagnosis, prophylaxis, and treatment, along with special considerations for different types of HCT recipients and future research directions.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Article
Infectious Diseases
Chin Fen Neoh, Sharon C. A. Chen, David C. M. Kong, Kate Hamilton, Quoc A. Nguyen, Tim Spelman, Michelle Tew, Emma L. Harvey, Su Ann Ho, Natalie R. Saunders, Surekha Tennakoon, Amy Crowe, Debbie Marriott, Jason A. Trubiano, Monica A. Slavin
Summary: The economic burden of invasive Scedosporium/L. prolificans infections is substantial, with an adjusted median excess cost of AUD36,422 and a length of stay of 16.27 days during index hospitalization. The cumulative cost can increase significantly to AUD203,292 over 1.5 years in cases with these infections.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Immunology
Jessica C. O'Keeffe, Nikhil Singh, Monica A. Slavin
Summary: This review provides a comprehensive overview of pretransplant workup, identification, and prevention of invasive fungal diseases (IFDs) in patients with hematological malignancy. Assessing risk factors and implementing appropriate prophylactic measures during the pretransplant period are essential for effectively preventing IFD.
TRANSPLANT INFECTIOUS DISEASE
(2023)
