Review
Immunology
Hui Chen, Na Liu, Shougang Zhuang
Summary: Macrophages play a crucial role in kidney injury, and targeting their activation mechanisms can significantly improve the outcomes of AKI.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biophysics
I Garcia-Arnaez, F. Romero-Gavilan, A. Cerqueira, F. Elortza, M. Azkargorta, F. Munoz, M. Mata, J. J. Martin de Llano, J. Suay, M. Gurruchaga, I Goni
Summary: This study used proteomic and histological techniques to analyze the effects of Ca-doped biomaterials in vitro and in vivo and verify the correlation between the two systems. The results showed that the proteomic analysis of biomaterials in vitro is a useful tool for predicting their impact in vivo.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Pharmacology & Pharmacy
Fei Feng, Lin-Jun Wang, Jian-Chun Li, Ting-Ting Chen, Liping Liu
Summary: This article mainly describes the mechanism of Heparanase (HPA) on Acute Respiratory Distress Syndrome (ARDS), indicating its important role in inflammation, coagulation, and fibrosis. It also speculates that HPA promotes the occurrence and development of ARDS through exosomes and autophagy, resulting in the release of inflammatory factors, coagulation disorder, and pulmonary fibrosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Urology & Nephrology
Stephen J. McWilliam, Rachael D. Wright, Gavin Welsh, Jack Tuffin, Kelly L. Budge, Laura Swan, Thomas Wilm, Ioana-Roxana Martinas, James Littlewood, Louise Oni
Summary: Acute kidney injury (AKI) is a serious condition with various causes, including hypovolaemia, nephrotoxic medications, ischaemia, and acute glomerulonephritis, leading to inflammation and potential progression to chronic kidney disease. Early detection of biomarkers is crucial for identifying high-risk patients and providing personalized treatment.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Peripheral Vascular Disease
Junni Wang, Wanyun Nie, Xishao Xie, Mengqiu Bai, Yanhong Ma, Lini Jin, Liang Xiao, Peng Shi, Yi Yang, Pedro A. Jose, Ines Armando, Jianghua Chen, Weiqiang Lin, Fei Han
Summary: The study identified the role of microRNA-874-3p/ADAM19 in mediating renal fibrosis after acute kidney injury by increasing macrophage infiltration via the Notch1/CCL2 pathway. Modulating the levels of microRNA-874-3p or ADAM19 could potentially slow down the process of renal fibrosis.
Article
Immunology
Erica Bazzan, Alvise Casara, Claudia Maria Radu, Mariaenrica Tine, Davide Biondini, Eleonora Faccioli, Federica Pezzuto, Nicol Bernardinello, Maria Conti, Elisabetta Balestro, Fiorella Calabrese, Paolo Simioni, Federico Rea, Graziella Turato, Paolo Spagnolo, Manuel G. Cosio, Marina Saetta
Summary: This study found that FXIIIA is expressed at higher levels in alveolar macrophages and dendritic cells in COPD patients, and is closely related to inflammatory response and disease progression.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Minjung Son, Ga Young Kim, Yejin Yang, Sugyeong Ha, Jeongwon Kim, Doyeon Kim, Hae Young Chung, Hyung Ryong Moon, Ki Wung Chung
Summary: The PPAR pan agonist MHY2013 effectively prevents renal fibrosis in both in vitro and in vivo models, suggesting its therapeutic potential against chronic kidney diseases. MHY2013 inhibits fibroblast activation and reduces inflammation through PPAR gamma and beta activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Alton Brad Farris, Juan Vizcarra, Mohamed Amgad, Lee Alex Donald Cooper, David Gutman, Julien Hogan
Summary: Digital pathology technology allows for automatic detection of glomeruli and selection of cortical regions of interest in kidney allograft biopsy specimens. The automatic fibrosis quantification was moderately correlated with pathologists' assessment, but not significantly associated with eGFR or allograft survival. This pipeline provides a promising method for developing and applying image analysis algorithms in kidney pathology.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Pharmacology & Pharmacy
Yejin Yang, Sugyeong Ha, Somi Jeong, Chae Won Jang, Jeongwon Kim, Dong-Soon Im, Hae Young Chung, Ki Wung Chung
Summary: This study compared two reliable toxin-induced mouse kidney fibrosis models in terms of fibrosis and inflammation. The adenine diet-induced kidney fibrosis model exhibited higher inflammatory response with increased fibrosis compared to the folic acid-induced kidney fibrosis model.
Review
Cell Biology
Vivian Jou, Jessica A. Lehoczky
Summary: Understanding the natural regeneration capability of vertebrates, particularly mammals, is crucial for potential therapeutic applications in humans. While mammals have low regenerative capacity for composite tissues like the limb, some primates and rodents can regenerate the distal tips of their digits. The successful regeneration depends on the location of the amputation, with proximal amputations resulting in fibrosis instead of regeneration. This duality of regeneration and fibrosis in the mouse digit tip serves as a model to study the factors involved in each process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Alexander J. Whitehead, Adam J. Engler
Summary: This study compared regenerative mouse hearts with nonregenerative hearts and found that sterile inflammatory processes are upregulated in nonregenerative hearts, initiating profibrotic gene programs 3 days after myocardial infarction that can cause myocardial disease.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Review
Immunology
Yi Wen, Hong-Ru Yan, Bin Wang, Bi-Cheng Liu
Summary: Kidney macrophages play crucial roles in the pathogenesis of kidney diseases, with diverse functions ranging from clearing pathogens to promoting fibrosis. Their origins and proliferation are key factors in the accumulation of macrophages after kidney injury. Understanding the mechanisms driving macrophage heterogeneity and function changes could help in the development of targeted therapies for kidney diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Robson E. Silva, Eliziaria C. Santos, Patricia B. Justino, Margarida P. Santos, Giovane Galdino, Reggiani Goncalves, Romulo D. Novaes
Summary: The relationship between dialysis adequacy and circulating levels of inflammatory mediators was investigated, showing that low Kt/V results and creatinine accumulation may serve as potential indicators of systemic inflammatory stress.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Lan Xiao, Yaping Ma, Ross Crawford, Jayanti Mendhi, Yi Zhang, Haiping Lu, Qingyu Zhao, Jin Cao, Chengtie Wu, Xin Wang, Yin Xiao
Summary: Treatment of large bone defects and bone non-union remains a clinical challenge. Hematoma plays an essential role in bone healing, and an ideal fibrin structure can facilitate bone regeneration. Immunoregulation is important for bone healing. The balance between coagulation-inflammation and anti-coagulation-anti-inflammation is crucial for fibrin structure and bone healing microenvironment.
Review
Biochemistry & Molecular Biology
Axel Lorentz, Sabrina Bilotta, Mehtap Civelek
Summary: Epidemiologic studies have shown both positive and negative associations between allergies and cancer. Allergic diseases can protect against tumorigenesis through immune surveillance, while carcinogenesis may be promoted by inflammatory responses from allergies. Recent cancer studies have focused on histamine receptor antagonists, as they have shown promising effects on tumor development. Additionally, cytokines such as IL-4 or IL-33, IgE, and allergy-related immune cells like eosinophils may contribute to tumor growth suppression.
TRENDS IN MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Nisha Sharma, Anannya Sircar, Hans-Joachim Anders, Anil Bhanudas Gaikwad
Summary: Liver and kidney play vital roles in maintaining homeostasis and their injuries can affect each other. Excessive fructose intake, insulin resistance, inflammatory cytokines production, activation of the renin-angiotensin system, and redox imbalance are involved in the interaction between liver and kidney. AKI and NAFLD have impacts on liver and kidney functions through various biochemical and molecular pathways.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Review
Urology & Nephrology
Stefanie Steiger, Jan Rossaint, Alexander Zarbock, Hans-Joachim Anders
Summary: Kidney disease is a significant risk factor for poor outcomes in COVID-19 and other infections. Infection is also a common cause of death in patients with kidney disease. Despite this, there is limited understanding and research on the secondary immunodeficiency related to kidney disease (SIDKD). This study aims to raise awareness of SIDKD as a critical unmet medical need, reviewing its epidemiology and discussing the abnormal immunophenotype in kidney disease patients. It proposes a definition for SIDKD and explores the pathogenic mechanisms involved, including the role of FGF23 levels, hyperuricemia, and changes in the secretome of the gut microbiota in kidney disease. The ultimate goal is to develop therapeutics that can improve immune responses and reduce mortality from infections in kidney disease patients.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Review
Urology & Nephrology
Valerie A. Luyckx, Andrew D. Rule, Katherine R. Tuttle, Pierre Delanaye, Helen Liapis, Afschin Gandjour, Paola Romagnani, Hans-Joachim Anders
Summary: This article highlights the importance of kidney lifespan in understanding chronic kidney disease. Adaptive adjustments of nephrons are crucial for maintaining kidney function and structure, and the progression of kidney disease due to nephron loss is closely related to individual kidney function status.
NATURE REVIEWS NEPHROLOGY
(2022)
Article
Cell Biology
Viviane Gnemmi, Qiubo Li, Qiuyue Ma, Letizia De Chiara, Giulia Carangelo, Chenyu Li, Mireia Molina-Van den Bosch, Paola Romagnani, Hans-Joachim Anders, Stefanie Steiger
Summary: Asymptomatic hyperuricemia may attenuate acute kidney disease (AKD) and promote kidney function recovery. This is due to the beneficial antioxidant effects of soluble uric acid on macrophages and tubular cells.
Review
Endocrinology & Metabolism
Michael T. Collins, Gemma Marcucci, Hans-Joachim Anders, Giovanni Beltrami, Jane A. Cauley, Peter R. Ebeling, Rajiv Kumar, Agnes Linglart, Luca Sangiorgi, Dwight A. Towler, Ria Weston, Michael. P. Whyte, Maria Luisa Brandi, Bart Clarke, Rajesh V. Thakker
Summary: This review discusses the main regulators of mineralization and crystallization processes in human physiology, as well as related disorders. Advances in the past decade have improved understanding of these disorders and their genetic, molecular, and cellular mechanisms, leading to potential new therapeutic approaches.
NATURE REVIEWS ENDOCRINOLOGY
(2022)
Editorial Material
Urology & Nephrology
Hans-Joachim Anders, Peter Boor
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chao Han, Pengxuan Ren, Medina Mamtimin, Linus Kruk, Edita Sarukhanyan, Chenyu Li, Hans-Joachim Anders, Thomas Dandekar, Irena Krueger, Margitta Elvers, Silvia Goebel, Kristin Adler, Goetz Muench, Thomas Gudermann, Attila Braun, Elmina Mammadova-Bach
Summary: This study analyzed the collagen- and CRP-binding surfaces of GPVI monomers and dimers using computational modeling and bioinformatics, and compared them with other mammalian GPVI isoforms. Experimental results show that the EA-20 antibody inhibits platelet adhesion and aggregation in response to collagen and CRP, but not to fibrin, and prevents thrombus formation in whole blood. Therefore, the blockade of this minimal collagen-binding epitope of GPVI with the EA-20 antibody could represent a new anti-thrombotic approach.
Article
Biochemistry & Molecular Biology
Andrea Ribeiro, Feiyue Liu, Matthias Srebrzynski, Simone Rother, Karina Adamowicz, Marta Wadowska, Stefanie Steiger, Hans-Joachim Anders, Christoph Schmaderer, Joanna Koziel, Maciej Lech
Summary: In this study, the impact of uremic toxin indoxyl sulfate on macrophages and tubular epithelial cells and its role in modulating the response to lipopolysaccharide (LPS) were investigated. Indoxyl sulfate, which accumulates in the blood of patients with chronic kidney disease (CKD), was found to induce low-grade inflammation and modulate macrophage function. Additionally, it was shown to enhance the inflammatory response associated with LPS and contribute to the senescence of tubular epithelial cells during injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Transplantation
Paola Romagnani, A. Richard Kitching, Nelson Leung, Hans-Joachim Anders
Summary: Glomerulonephritis (GN) is a diverse group of immune-mediated disorders, which cannot be properly classified or treated based on histological patterns alone. To overcome this problem, a new classification system is proposed that considers disease category, immunological activity, and chronicity, which will guide the therapeutic approach.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Hans-Joachim Anders, Gema M. Fernandez-Juarez, Augusto Vaglio, Paola Romagnani, Juergen Floege
Summary: The management of immune-mediated kidney diseases focuses on controlling the underlying immune disease process and the non-immune mechanisms of chronic kidney disease (CKD) progression. Non-pharmacological interventions, such as reducing salt intake and regular physical activity, along with approved drug interventions, can help attenuate CKD progression.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Editorial Material
Transplantation
Hans-Joachim Anders
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Oncology
Linus Kruk, Medina Mamtimin, Attila Braun, Hans-Joachim Anders, Joachim Andrassy, Thomas Gudermann, Elmina Mammadova-Bach
Summary: Inflammation plays a crucial role in the progression and metastasis of renal cell carcinoma by regulating the interaction between tumor cells and the tumor microenvironment. This review summarizes recent research on the role of inflammation in RCC tumors and discusses potential inflammatory pathways as therapeutic targets.
Review
Biochemistry & Molecular Biology
Chongxu Shi, Elmina Mammadova-Bach, Cong Li, Dong Liu, Hans-Joachim Anders
Summary: Cholesterol crystal (CC) embolism is a complication of advanced atherosclerotic plaques primarily induced by interventional and surgical procedures. Prophylaxis through plaque stabilization and avoiding unnecessary catheter interventions is the main approach to CC embolism. Platelet inhibitors and anticoagulants may reduce the risk of vascular occlusions and tissue ischemia in case CC embolism occurs. Given the unmet medical need, effective treatment strategies for CC embolism are urgently needed.
Review
Cell Biology
Ajinath Kale, Vishwadeep Shelke, Yutian Lei, Anil Bhanudas Gaikwad, Hans-Joachim Anders
Summary: This article reviews the unique chemistry, pharmacology, and toxicity profile of the novel calcineurin inhibitor (CNI) Voclosporin and summarizes its efficacy and safety data in the treatment of active lupus nephritis. The article also discusses possible options for implementing Voclosporin in the management of lupus nephritis, including patient stratification, combination therapy, sequential therapy, and alternative options.
Review
Immunology
Hans-Joachim Anders, A. Richard Kitching, Nelson Leung, Paola Romagnani
Summary: 'Glomerulonephritis' (GN) refers to a group of immune-mediated disorders characterized by inflammation of the kidney's filtration units. Current classification is based on histopathological lesion patterns, but these patterns do not align well with the diverse pathological mechanisms and do not guide optimal therapy. Instead, a proposed immunopathogenesis-based classification groups GN disorders into five categories, allowing for more targeted and effective treatments.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Marijn A. Scheijde-Vermeulen, Lennart A. Kester, Liset Westera, Bastiaan B. J. Tops, Friederike A. G. Meyer-Wentrup
Summary: This study aimed to evaluate the feasibility of integrating state-of-the-art sequencing techniques and flow cytometry into the diagnostic workup of pediatric lymphoma. The results showed that this integration is not only feasible but also provides additional diagnostic information.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Enrico Berrino, Sara Erika Bellomo, Anita Chesta, Paolo Detillo, Alberto Bragoni, Amedeo Gagliardi, Alessio Naccarati, Matteo Cereda, Gianluca Witel, Anna Sapino, Benedetta Bussolati, Gianni Bussolati, Caterina Marchi
Summary: Formalin-fixed paraffin-embedded (FFPE) samples are crucial for tissue-based analysis in precision medicine, but the quality of these samples can affect the reliability of sequencing data. The use of acid-deprived fixatives guarantees the highest DNA preservation and sequencing performance, enabling more complex molecular profiling of tissue samples.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Roope A. Kallionpaa, Sirkku Peltonen, Kim My Le, Eija Martikkala, Mira Jaaskelainen, Elnaz Fazeli, Pilvi Riihila, Pekka Haapaniemi, Anne Rokka, Marko Salmi, Ilmo Leivo, Juha Peltonen
Summary: This study investigated the immune microenvironment of cutaneous neurofibromas (cNFs) in patients with neurofibromatosis 1 (NF1). The results showed that cNFs have substantial populations of T cells and macrophages, which may be tumor-specific. T cell populations in cNFs were found to be different from those in the skin, and cNFs exhibited lower expression of proteins related to T cell-mediated immunity compared to the skin.
LABORATORY INVESTIGATION
(2024)